iPTMnet Report for P01023 (A2M)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01023 / A2MG_HUMAN
Protein Name Alpha-2-macroglobulin precursor
Gene Name Name: A2M
Synonyms:CPAMD5;ORFNames:FWP007;
Organism Homo sapiens (Human)

PRO ID PR:P01023
DAG View
PRO Name alpha-2-macroglobulin (human)
Definition An alpha-2-macroglobulin that is encoded in the genome of human.
Short Label hA2M
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01023 (A2M) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 O-Glycosylation GlyGen 30459171
N55 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 19139490, ...29741879, 34725484
N70 N-Glycosylation GlyGen   UniProt 6203908
N247 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...29741879, 6203908
T346 Phosphorylation PhosphoSitePlus
N396 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...19159218, 6203908
N410 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...6203908
Y497 Phosphorylation PhosphoSitePlus
C563 Methylation IEDB 31844290
S575 O-Glycosylation GlyGen 30459171
T588 O-Glycosylation GlyGen 30459171
T654 O-Glycosylation GlyGen 30459171
T679 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y695 Phosphorylation PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
T763 O-Glycosylation GlyGen 30459171
Y817 Phosphorylation PhosphoSitePlus
K820 Acetylation PhosphoSitePlus
K841 Ubiquitination IEDB 34433824
T861 Phosphorylation PhosphoSitePlus
N869 N-Glycosylation GlyGen   IEDB   UniProt 16335952, 34725484, 23090970, ...14760718, 24279413, 29741879, 29671580, 27550523
T885 O-Glycosylation GlyGen 30459171
T898 Phosphorylation PhosphoSitePlus
N991 N-Glycosylation GlyGen   UniProt 16335952, 29741879, 12754519, ...19159218, 6203908
Y1007 Phosphorylation PhosphoSitePlus
Y1012 Phosphorylation PhosphoSitePlus
Y1021 Phosphorylation PhosphoSitePlus
Y1025 Phosphorylation PhosphoSitePlus
K1147 Acetylation PhosphoSitePlus
K1162 Acetylation PhosphoSitePlus
K1164 Acetylation PhosphoSitePlus
K1168 Acetylation PhosphoSitePlus
S1387 Phosphorylation PhosphoSitePlus
T1395 Phosphorylation PhosphoSitePlus
N1424 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...19159218, 23090970, 14760718, 29391424, 19139490, 24279413, 18514042, 29741879, 29671580
Site PTM Type PTM Enzyme Score Source PMID
N247 N-Glycosylation PRO 29671580
N396 N-Glycosylation PRO 29671580
N410 N-Glycosylation PRO 29671580
N869 N-Glycosylation PRO 29671580
N1424 N-Glycosylation PRO 24279413, 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N410 T410 Biomuta DOID:1324 / lung cancer [ cosmic ]
S575 P575 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S575 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y695 C695 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y817 C817 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T885 A885 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1025 C1025 Biomuta DOID:363 / uterine cancer [ cosmic ]
K1162 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1387 Y1387 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1395 K1395 Biomuta DOID:1324 / lung cancer [ cosmic ]