iPTMnet Report P00533 EGFR

Protein Information

UniProt AC / UniProt ID	P00533 / EGFR_HUMAN
Protein Name	Epidermal growth factor receptor precursor
Gene Name	Name: EGFR Synonyms:ERBB,ERBB1,HER1;
Organism	Homo sapiens (Human)

PRO ID	PR:P00533 DAG View
PRO Name	epidermal growth factor receptor (human)
Definition	An epidermal growth factor receptor that is encoded in the genome of human.
Short Label	hEGFR
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P00533 (EGFR) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K37	Sumoylation		score1	PhosphoSitePlus
N56	N-Glycosylation		score3	GlyGen	12297050, 20837704, 12297049, ...12731890, 16083266, 10988252, 29391424, 10731668
N73	N-Glycosylation		score3	GlyGen UniProt	20837704
S77	Phosphorylation		score1	PhosphoSitePlus
Y88	Phosphorylation		score0	RLIMS-P	28245430
Y112	Phosphorylation		score1	PhosphoSitePlus
Y113	Phosphorylation		score1	PhosphoSitePlus
Y117	Phosphorylation		score1	PhosphoSitePlus
N128	N-Glycosylation		score4	GlyGen UniProt	10731668, 8962717, 12731890, ...16083266, 10988252
K133	Acetylation		score1	PhosphoSitePlus
S151	Phosphorylation		score1	PhosphoSitePlus
N175	N-Glycosylation		score4	GlyGen UniProt	8962717, 12297050, 29391424, ...12731890, 16083266, 20837704, 10988252, 10731668
C190	S-Nitrosylation		score2	dbSNO	19056486, 22178444
N196	N-Glycosylation		score4	GlyGen UniProt	12297050, 12297049, 12731890, ...16083266, 20837704, 29741879
K212	Ubiquitination		score1	PhosphoSitePlus
R222	Methylation		score1	PhosphoSitePlus
R224	Methylation		score1	PhosphoSitePlus
S229	Phosphorylation	P31749 (AKT1)	score3	neXtProt PhosphoSitePlus RLIMS-P UniProt	21487020
K253	Acetylation		score1	PhosphoSitePlus
N271	N-Glycosylation		score1	GlyGen	29391424
K284	Acetylation		score1	PhosphoSitePlus
T290	Phosphorylation		score1	PhosphoSitePlus
C291	S-Nitrosylation		score0	dbSNO	20140087, 22178444
K293	Ubiquitination		score1	PhosphoSitePlus
C311	S-Nitrosylation		score0	dbSNO	20140087, 22178444
C329	S-Nitrosylation		score2	dbSNO	19056486, 22178444
K346	Acetylation		score1	PhosphoSitePlus
N352	N-Glycosylation		score4	GlyGen UniProt	12297050, 19159218, 24190977, ...23090970, 12297049, 12731890, 16083266, 20837704, 10988252, 29741879, 10731668, 12620237
T354	Phosphorylation		score1	PhosphoSitePlus
N361	N-Glycosylation		score4	GlyGen UniProt	12297050, 24190977, 23090970, ...29391424, 12731890, 16083266, 20837704, 10988252, 29741879, 10731668, 12620237
S364	O-Glycosylation		score3	GlyGen	33214551, 26108188, 31492838, ...30059200, 34019948, 30962710, 35289036, 28510447, 33465208, 29237092
S380	O-Glycosylation		score3	GlyGen	33214551, 26108188, 31492838, ...30059200, 34019948, 30962710, 35289036, 28510447, 33465208, 29237092
K396	Ubiquitination		score1	PhosphoSitePlus
N413	N-Glycosylation		score4	GlyGen UniProt	8962717, 19159218, 12731890, ...16083266, 10988252, 29741879, 10731668
T430	O-Glycosylation		score3	GlyGen	33214551, 26108188, 31492838, ...30059200, 34019948, 30962710, 35289036, 28510447, 33465208, 29237092
T430	Phosphorylation		score1	PhosphoSitePlus
S437	O-Glycosylation		score1	GlyGen	33465208
S442	O-Glycosylation		score1	GlyGen	33465208
N444	N-Glycosylation		score4	GlyGen UniProt	8962717, 12297050, 20837704, ...12731890, 16083266, 10988252, 10731668, 12620237
S457	Phosphorylation		score1	PhosphoSitePlus
N468	N-Glycosylation		score1	GlyGen	29391424
C470	S-Nitrosylation		score0	dbSNO	20140087, 22178444
T474	O-Glycosylation		score3	GlyGen	33214551, 26108188, 31492838, ...30059200, 34019948, 30962710, 35289036, 28510447, 33465208, 29237092
K479	Ubiquitination		score1	PhosphoSitePlus
K487	Ubiquitination		score1	PhosphoSitePlus
K489	Ubiquitination		score1	PhosphoSitePlus
S511	Phosphorylation		score1	PhosphoSitePlus
N528	N-Glycosylation		score4	GlyGen UniProt	8962717, 25922362, 12731890, ...16083266, 20837704, 10988252, 10731668, 12620237
K538	Ubiquitination		score1	PhosphoSitePlus
N568	N-Glycosylation		score4	GlyGen UniProt	19159218, 12731890, 16083266, ...10988252, 10731668, 12620237
Y585	Phosphorylation		score1	PhosphoSitePlus
N603	N-Glycosylation		score4	GlyGen UniProt	24190977, 23090970, 29391424, ...12731890, 16083266, 10988252, 29741879, 10731668, 12620237
N623	N-Glycosylation		score4	GlyGen UniProt	23090970, 24190977, 12731890
S645	Phosphorylation		score1	PhosphoSitePlus
T648	Phosphorylation		score1	PhosphoSitePlus
L654	Phosphorylation		score2	IntAct	20692258
T678	Phosphorylation	Q16512 (PKN1) , P17252 (PRKCA) , Q15139 (PRKD1) , Q6P5Z2 (PKN3)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	34155348, 6090944, 15302935, ...3379075, 21749319, 1860884, 10816576, 12359306, 10523301
T693	Phosphorylation	P28482 (MAPK1) , P27361 (MAPK3) , Q16539 (MAPK14) , Q15139 (PRKD1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18669648, 16785992, 17192257, ...1939237, 2543683, 22703031, 18691976, 23186163, 34086370, 23723255, 24275569, 34295309, 1651323, 1651322, 18220336, 10523301, 17081983, 15302935, 16083266, 2115882, 3138233, 20068231
S695	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	18691976, 15302935, 1956339, ...18669648, 3138233
K708	Ubiquitination		score1	PhosphoSitePlus
K713	Ubiquitination		score1	PhosphoSitePlus
K714	Ubiquitination		score1	PhosphoSitePlus
K716	Ubiquitination		score4	PhosphoSitePlus UniProt	16543144, 33996800
S720	Phosphorylation		score1	PhosphoSitePlus
T725	Phosphorylation		score1	PhosphoSitePlus
Y727	Phosphorylation	P12931 (SRC)	score4	IntAct PhosphoSitePlus	15657067, 16729043
K728	Ubiquitination		score1	PhosphoSitePlus
K737	Ubiquitination		score4	PhosphoSitePlus UniProt	16543144, 33996800
K739	Ubiquitination		score1	PhosphoSitePlus
K745	Methylation		score1	PhosphoSitePlus
K745	Ubiquitination		score1	PhosphoSitePlus
S752	Phosphorylation		score1	PhosphoSitePlus
K754	Ubiquitination		score4	PhosphoSitePlus UniProt	16543144, 33996800
K757	Ubiquitination		score3	PhosphoSitePlus UniProt	33996800
Y764	Phosphorylation	P12931 (SRC)	score2	PhosphoSitePlus	15657067
S768	Phosphorylation	Q9UQM7 (CAMK2A)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	15302935, 10347170, 29695735
T790	Phosphorylation		score1	RLIMS-P	25375092, 30925736, 27279914, ...32512509, 26629323
Y801	Phosphorylation		score1	PhosphoSitePlus
N816	N-Glycosylation		score1	GlyGen	29391424
K823	Ubiquitination		score1	PhosphoSitePlus
Y827	Phosphorylation		score1	PhosphoSitePlus
V845	Phosphorylation		score2	IntAct	23866081
K846	Ubiquitination		score1	PhosphoSitePlus
K852	Ubiquitination		score1	PhosphoSitePlus
K860	Ubiquitination		score1	PhosphoSitePlus
K867	Ubiquitination		score4	PhosphoSitePlus UniProt	16543144, 33996800
Y869	Phosphorylation	P00533 (EGFR) , P12931 (SRC) , Q13882 (PTK6)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	17877814, 25427151, 23774213, ...10075741, 11983694, 19305428, 22231447, 33328764, 19935697, 31492560, 17646646, 18083107, 17653080, 10653583, 16273093, 14512423, 16943190
K875	Ubiquitination		score1	PhosphoSitePlus
Y891	Phosphorylation		score3	IntAct PhosphoSitePlus	16729043
T892	Phosphorylation	Q13131 (PRKAA1)	score2	PhosphoSitePlus	26143491
K913	Ubiquitination		score1	PhosphoSitePlus
Y915	Phosphorylation	P12931 (SRC)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus	11983694, 16273093, 7797556
K929	Ubiquitination		score3	PhosphoSitePlus UniProt	16543144
T940	Phosphorylation		score1	PhosphoSitePlus
Y944	Phosphorylation	P12931 (SRC)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus	11983694, 7797556
K960	Ubiquitination		score3	PhosphoSitePlus UniProt	33996800
K970	Ubiquitination		score3	PhosphoSitePlus UniProt	16543144
Y978	Phosphorylation		score4	IntAct phospho.ELM PhosphoSitePlus	16729043, 12070153, 16097034
S991	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	17081983, 15901825, 18220336, ...29802988, 16083266, 18669648, 24275569, 20068231, 19531499
T993	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S995	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
Y998	Phosphorylation	P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19563760, 17081983, 31725811, ...15951569, 18669648, 22559222, 17646646, 16729043, 16273093, 19531499
Y1016	Phosphorylation	P12931 (SRC) , P00519 (ABL1) , P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	19563760, 23774213, 1688559, ...7685104, 15302935, 10653583, 7680558, 8845374, 24935154, 7797556, 1314835, 8621392, 32245944, 17575160, 16729043, 7693694, 16273093, 16943190
S1025	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S1026	Phosphorylation	P06493 (CDK1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15302935, 18669648, 16083266, ...24275569, 8360196
S1028	Phosphorylation		score1	phospho.ELM	18669648, 15302935
S1030	Phosphorylation		score1	PhosphoSitePlus
T1032	Phosphorylation		score1	PhosphoSitePlus
S1037	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S1039	Phosphorylation	Q16539 (MAPK14) , Q15759 (MAPK11)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 24797263, 17081983, ...19531499
T1041	Phosphorylation	Q15759 (MAPK11) , Q16539 (MAPK14)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 19531499
S1042	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 17081983
S1045	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17081983
T1046	Phosphorylation		score1	PhosphoSitePlus
S1057	Phosphorylation		score1	PhosphoSitePlus
K1061	Acetylation		score1	PhosphoSitePlus
K1061	Ubiquitination		score1	PhosphoSitePlus
S1064	Phosphorylation	Q9UQM7 (CAMK2A)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	18691976, 23186163, 17081983, ...18669648, 10347170, 20068231
Y1069	Phosphorylation	P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	19563760, 23774213, 19531499, ...15302935, 18669648, 22888118, 10635327, 16729043, 31460159, 17081983
S1070	Phosphorylation	Q9UQM7 (CAMK2A)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	7505275, 1309762, 28873083, ...23254288, 15302935, 1956339, 20877636, 10347170, 3138233, 7805884
S1071	Phosphorylation	Q13555 (CAMK2G) , Q9UQM7 (CAMK2A)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	7505275, 1309762, 15302935, ...1956339, 20877636, 10347170, 3138233, 7805884
T1074	Phosphorylation		score1	PhosphoSitePlus
T1078	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S1081	Phosphorylation	Q9UQM7 (CAMK2A)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	18691976, 18669648, 10347170, ...15302935
T1085	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
Y1092	Phosphorylation	O60674 (JAK2) , P00519 (ABL1) , P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	3263271, 16943190, 28724430, ...14966128, 17646646, 27153536, 10229072, 17877814, 7527043, 11896612, 8940013, 15737014, 15329413, 16729043, 26370283, 12873986, 9363897, 31537844, 9153411, 23825523, 7993895, 8845374, 2543678, 7518560, 17726540, 9733788, 23774213, 17081983, 15302935, 1314835, 18083107, 10653583, 19531499
S1096	Phosphorylation		score1	PhosphoSitePlus
K1099	Ubiquitination		score1	PhosphoSitePlus
S1104	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17081983
Y1110	Phosphorylation	P12931 (SRC) , P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	25168820, 17646646, 7527043, ...26921391, 12873986, 15302935, 8845374, 26274523, 7797556, 14966128, 2543678, 1314835, 10653583, 7518560, 16729043, 19935697, 2803273, 16273093
S1120	Phosphorylation	Q9UQM7 (CAMK2A)	score3	PhosphoSitePlus Signor	10347170
Y1125	Phosphorylation	P12931 (SRC)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus Signor	10075741, 11983694, 8845374, ...16729043, 16273093
S1130	Phosphorylation		score1	PhosphoSitePlus
T1131	Phosphorylation		score1	PhosphoSitePlus
Y1138	Phosphorylation	P00533 (EGFR)	score4	IntAct neXtProt PhosphoSitePlus	16729043, 17646646, 16273093
T1141	Phosphorylation		score1	PhosphoSitePlus
T1145	Phosphorylation		score1	PhosphoSitePlus
T1150	Phosphorylation		score1	PhosphoSitePlus
S1153	Phosphorylation		score1	PhosphoSitePlus
K1160	Ubiquitination		score1	PhosphoSitePlus
S1162	Phosphorylation		score1	PhosphoSitePlus
S1166	Phosphorylation	Q9UQM7 (CAMK2A)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	22703031, 18691976, 29802988, ...15302935, 18669648, 10347170, 24275569
Y1172	Phosphorylation	P00519 (ABL1) , P12931 (SRC) , P00533 (EGFR)	score4	IEDB IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	18083107, 35494241, 3263271, ...17081983, 9733788, 15302935, 8845374, 16273093, 31492560, 22559222, 2543678, 1314835, 10653583, 27153536, 17646646, 16729043, 19935697, 27281782, 12454019, 16943190
K1179	Acetylation		score1	PhosphoSitePlus
K1179	Ubiquitination		score1	PhosphoSitePlus
K1182	Acetylation		score1	PhosphoSitePlus
K1182	Ubiquitination		score1	PhosphoSitePlus
K1188	Acetylation		score1	PhosphoSitePlus
K1188	Methylation		score1	PhosphoSitePlus
K1188	Ubiquitination		score1	PhosphoSitePlus
S1190	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
T1191	Phosphorylation		score1	PhosphoSitePlus
A1192	Phosphorylation		score2	IntAct	16273093
Y1197	Phosphorylation	P00519 (ABL1) , P00533 (EGFR)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	3263271, 16943190, 30615629, ...17646646, 27153536, 22703031, 18691976, 9544989, 7693694, 16729043, 26370283, 19836242, 7542744, 8845374, 19935697, 31492560, 2543678, 7518560, 9733788, 23774213, 19563760, 29556515, 17081983, 15302935, 1314835, 18083107, 10653583, 20068231, 8034616
R1199	Methylation		score2	UniProt	21258366

Site	PTM Type	PTM Enzyme	Score	Source	PMID
N56	N-Glycosylation		score3	PRO	10731668, 10988252
N128	N-Glycosylation		score3	PRO	10731668, 10988252
N175	N-Glycosylation		score3	PRO	10731668, 10988252
T290	Phosphorylation		score0	HPRD	18452278
N352	N-Glycosylation		score3	PRO	10731668, 10988252
N361	N-Glycosylation		score3	PRO	10731668, 10988252
N413	N-Glycosylation		score3	PRO	10731668, 10988252
N444	N-Glycosylation		score3	PRO	10731668, 10988252
N528	N-Glycosylation		score3	PRO	10731668, 10988252
N568	N-Glycosylation		score3	PRO	10731668, 10988252
N603	N-Glycosylation		score3	PRO	10731668, 10988252
T678	Phosphorylation	Q05655 (PRKCD)	score2	HPRD	2987962, 2984676
T693	Phosphorylation		score2	HPRD	19413330, 18691976, 16799092, ...20058876, 15302935, 18669648, 18491316, 2543683, 18767875, 20068231
S695	Phosphorylation		score2	HPRD	18691976, 18669648, 18491316, ...92065884, 20068231
S720	Phosphorylation		score0	HPRD	20068231
T725	Phosphorylation		score0	HPRD	18691976, 20068231
Y727	Phosphorylation		score2	HPRD	16729043, 20068231
S768	Phosphorylation	Q9UQM7 (CAMK2A)	score3	HPRD PRO	10347170
Y869	Phosphorylation	P12931 (SRC)	score4	HPRD PRO	11983694, 16729043, 18789131
Y891	Phosphorylation		score1	HPRD	16729043
Y915	Phosphorylation	P12931 (SRC)	score2	HPRD	11983694, 16729043
Y944	Phosphorylation	P12931 (SRC)	score2	HPRD	11983694, 16729043
Y978	Phosphorylation		score1	HPRD	16729043
S991	Phosphorylation		score2	HPRD	18691976, 17389395, 19651622, ...18669648, 16799092, 20068231
T993	Phosphorylation		score0	HPRD	19651622, 18669648, 20068231
S995	Phosphorylation		score0	HPRD	19651622, 18669648, 17081983, ...20068231
Y998	Phosphorylation	P12931 (SRC)	score2	HPRD	17016520, 15951569, 16729043, ...17389395, 18669648
Y1016	Phosphorylation	P00533 (EGFR)	score2	HPRD	16729043, 16799092, 8845374
S1025	Phosphorylation		score0	HPRD	18691976, 18669648, 20068231
S1026	Phosphorylation		score2	HPRD	18691976, 18669648, 16799092
S1028	Phosphorylation		score0	HPRD	18669648
S1036	Phosphorylation		score0	HPRD	18691976, 17081983
S1037	Phosphorylation		score0	HPRD	18691976, 18669648, 17081983
S1039	Phosphorylation		score0	HPRD	18691976, 18669648, 17081983
T1041	Phosphorylation		score0	HPRD	18669648, 17081983
S1042	Phosphorylation		score0	HPRD	18691976, 18669648, 17081983
S1045	Phosphorylation		score0	HPRD	18767875, 18669648, 17081983
S1064	Phosphorylation	Q9UQM7 (CAMK2A)	score2	HPRD	18691976, 18669648, 10347170, ...20068231
Y1069	Phosphorylation	P00533 (EGFR) , P04626 (ERBB2) , O60674 (JAK2)	score2	HPRD	17016520, 18691976, 17389395, ...9363897, 18669648, 16799092, 10635327
S1070	Phosphorylation	Q13555 (CAMK2G) , Q9UQM7 (CAMK2A)	score4	HPRD PRO	16799092, 10347170, 1309762
S1071	Phosphorylation	Q13555 (CAMK2G) , Q9UQM7 (CAMK2A)	score4	HPRD PRO	10347170, 1309762
T1078	Phosphorylation		score0	HPRD	18669648
S1081	Phosphorylation	Q9UQM7 (CAMK2A)	score4	HPRD PRO	18691976, 16799092, 10347170, ...18669648, 20068231
T1085	Phosphorylation		score0	HPRD	18669648
Y1092	Phosphorylation	P12931 (SRC) , P00533 (EGFR)	score2	HPRD	17016520, 11983694, 16799092, ...8845374
Y1110	Phosphorylation	P00533 (EGFR)	score2	HPRD	17016520, 16729043, 16799092, ...8845374, 18707149
S1120	Phosphorylation	Q9UQM7 (CAMK2A)	score1	HPRD	10347170
Y1125	Phosphorylation	P12931 (SRC)	score2	HPRD	10075741, 16729043, 8845374, ...11983694
Y1138	Phosphorylation		score2	HPRD	16729043, 16799092
S1166	Phosphorylation	Q9UQM7 (CAMK2A)	score4	HPRD PRO	18691976, 17389395, 16799092, ...18669648, 10347170, 20166139, 20068231
Y1172	Phosphorylation	P00533 (EGFR)	score2	HPRD	17016520, 17389395, 8845374, ...19651622, 16799092, 16729043
Y1197	Phosphorylation	P00533 (EGFR)	score2	HPRD	17016520, 18691976, 16799092, ...17426253, 8845374, 17389395, 16729043, 20068231

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T290	Phosphorylation		score0	HPRD	18452278

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T290	Phosphorylation		score0	HPRD	18452278

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T290	Phosphorylation		score0	HPRD	18452278

P00533 (EGFR) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O14828-1 (SCAMP3)	Y41	score2	HPRD	9658162, 15144186
O14939-1 (PLD2)	Y179	score2	HPRD Signor	9837959
O14939 (PLD2)	Y296	score3	neXtProt PhosphoSitePlus	20176813
O14964 (HGS)	Y329	score4	HPRD phospho.ELM Signor	17016520, 12953068
O14964 (HGS)	Y334	score3	neXtProt Signor	12953068
O15126-1 (SCAMP1)	Y37	score1	HPRD	9658162
O15455 (TLR3)	Y858	score2	PhosphoSitePlus	22810896
O15492 (RGS16)	Y168	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	12588871, 11602604
O15492 (RGS16)	Y177	score3	HPRD phospho.ELM Signor	11602604
O60716 (CTNND1)	Y228	score4	HPRD neXtProt Signor	17016520, 17389395, 14996911, ...20068231
O75886-1 (STAM2)	Y192	score2	HPRD	19901323, 17389395, 10993906, ...11687594
O95477 (ABCA1)	S2054	score4	PhosphoSitePlus Signor	12196520, 26494466
P00533 (EGFR)	Y869	score4	neXtProt PhosphoSitePlus Signor	10653583, 17646646, 19935697
P00533 (EGFR)	Y998	score4	neXtProt UniProt	18669648, 19563760, 17646646
P00533-1 (EGFR)	Y1016	score4	HPRD neXtProt PhosphoSitePlus Signor UniProt	16799092, 1688559, 1314835, ...19563760, 8845374, 10653583, 17575160
P00533-1 (EGFR)	Y1069	score4	HPRD neXtProt Signor	17016520, 18691976, 17389395, ...19563760, 9363897, 18669648, 16799092, 10635327
P00533 (EGFR)	Y1092	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	17016520, 11983694, 3263271, ...1314835, 16799092, 2543678, 8845374, 10653583, 17646646, 9733788, 12873986
P00533 (EGFR)	Y1110	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	17016520, 16799092, 12873986, ...18707149, 1314835, 19935697, 2543678, 8845374, 10653583, 17646646, 16729043, 2803273
P00533 (EGFR)	Y1138	score2	neXtProt	17646646
P00533-1 (EGFR)	Y1172	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	17016520, 17389395, 17081983, ...8845374, 19935697, 19651622, 16799092, 2543678, 1314835, 10653583, 17646646, 16729043, 3263271, 9733788
P00533-1 (EGFR)	Y1197	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	17016520, 18691976, 16799092, ...17081983, 17426253, 8845374, 19935697, 17389395, 2543678, 1314835, 10653583, 17646646, 16729043, 3263271, 9733788, 20068231
P04083 (ANXA1)	Y21	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	24103589, 2457390
P04626-5 (ERBB2)	Y1218	score2	HPRD	11500516, 17426253, 17389395
P04626-1 (ERBB2)	Y1248	score3	HPRD Signor	1706616, 17389395, 17426253, ...12354693
P07948 (LYN)	Y32	score2	PhosphoSitePlus	23764002
P09211 (GSTP1)	Y4	score3	neXtProt PhosphoSitePlus Signor	19254954
P09211 (GSTP1)	Y8	score3	neXtProt PhosphoSitePlus Signor	19254954
P09211 (GSTP1)	Y199	score3	neXtProt PhosphoSitePlus Signor	19254954
P0DP23 (CALM1)	Y100	score3	HPRD Signor	17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 3415247, 18707149, 7925415, 12153558, 20068231, 16497976
P0DP24 (CALM2)	Y100	score1	Signor	3415247
P0DP25 (CALM3)	Y100	score1	Signor	3415247
P11171-4 (EPB41)	Y418	score3	HPRD neXtProt PhosphoSitePlus	1647028
P11171-3 (EPB41)	Y437	score1	HPRD	1647028
P11171 (EPB41)	Y660	score3	phospho.ELM Signor	1647028
P12004 (PCNA)	Y211	score4	neXtProt PhosphoSitePlus Signor	22692198, 17115032, 25825764
P14618 (PKM)	Y148	score2	PhosphoSitePlus	26759242
P15311 (EZR)	Y146	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	1382070, 15647376, 12560083
P15311 (EZR)	Y354	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	1382070, 15647376
P15941-7 (MUC1)	Y229	score2	HPRD	11152665, 11483589
P15941-11 (MUC1)	Y238	score2	HPRD	11152665, 11483589
P15941-8 (MUC1)	Y247	score1	HPRD	11483589
P15941 (MUC1)	Y1229	score3	phospho.ELM Signor	11483589
P18031 (PTPN1)	Y66	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	11106648, 11506178, 9355745
P19174 (PLCG1)	Y472	score4	HPRD neXtProt Signor	19901323, 1689310, 12601080
P19174 (PLCG1)	Y771	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	17016520, 17389395, 7682059, ...15144186, 8657103, 16038803, 1689310, 20068231, 16497976
P19174 (PLCG1)	Y783	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	17016520, 20068231, 17389395, ...9176240, 7682059, 8657103, 16038803, 1689310, 8885868, 16497976
P19174 (PLCG1)	Y1253	score3	neXtProt phospho.ELM Signor	1689310
P20936-2 (RASA1)	Y283	score1	HPRD	1850098
P20936-1 (RASA1)	Y460	score3	HPRD neXtProt phospho.ELM Signor	1850098
P21860 (ERBB3)	Y1276	score1	Signor	7929151
P21860 (ERBB3)	Y1289	score1	Signor	7929151
P22681 (CBL)	Y371	score2	neXtProt	10635327
P22681 (CBL)	Y700	score2	HPRD	11994282, 17389395, 11239464, ...15556646, 16497976
P22681 (CBL)	Y731	score2	HPRD	11994282, 10092522, 9890970, ...11239464, 10799548
P22681 (CBL)	Y774	score2	HPRD	11994282, 11239464, 15556646
P24844 (MYL9)	Y143	score2	phospho.ELM	8578591
P24844 (MYL9)	Y156	score2	phospho.ELM	8578591
P25098 (GRK2)	Y13	score2	neXtProt	18463167
P25098 (GRK2)	Y86	score2	neXtProt	18463167
P25098 (GRK2)	Y92	score2	neXtProt	18463167
P29353-3 (SHC1)	Y194	score2	PhosphoSitePlus	9388490
P29353-3 (SHC1)	Y195	score2	PhosphoSitePlus	9388490
P29353-2 (SHC1)	Y239	score2	neXtProt	9388490
P29353-2 (SHC1)	Y240	score2	neXtProt	9388490
P29353-3 (SHC1)	Y272	score2	PhosphoSitePlus	9388490
P29353-2 (SHC1)	Y317	score2	neXtProt	9388490
P30530 (AXL)	Y779	score2	RLIMS-P+	27775700
P35222 (CTNNB1)	Y142	score2	PhosphoSitePlus	22558232
P35222 (CTNNB1)	Y654	score4	neXtProt PhosphoSitePlus	14517306, 9233779
P37231-2 (PPARG)	Y74	score2	PhosphoSitePlus	26718225
P42224 (STAT1)	Y701	score4	HPRD RLIMS-P+	10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 11294897, 12637327
P42566-1 (EPS15)	Y849	score4	HPRD neXtProt Signor	17016520, 10953014, 17389395, ...24269888
P46108-1 (CRK)	Y221	score4	HPRD neXtProt Signor	11956190, 17016520, 9642287, ...8875975, 9480911, 12198159, 20068231
P48050 (KCNJ4)	Y234	score2	PhosphoSitePlus	21486282
P51692 (STAT5B)	Y699	score3	HPRD Signor	17016520, 11751923
P51692 (STAT5B)	Y725	score3	HPRD phospho.ELM Signor	11751923
P51692 (STAT5B)	Y740	score3	HPRD phospho.ELM Signor	11751923
P51692 (STAT5B)	Y743	score3	HPRD phospho.ELM Signor	11751923
P52735-3 (VAV2)	Y142	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	17016520, 17389395, 10618391, ...12454019
P52735 (VAV2)	Y159	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	11516622, 10618391, 12454019
P52735 (VAV2)	Y172	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10618391, 12454019
P61925 (PKIA)	Y8	score4	HPRD neXtProt phospho.ELM Signor	2434500, 1956339
P62993-2 (GRB2)	Y168	score1	HPRD	11726515
P62993 (GRB2)	Y209	score3	phospho.ELM Signor	11726515
P67775 (PPP2CA)	Y307	score3	neXtProt PhosphoSitePlus	1325671
Q05397 (PTK2)	Y5	score3	neXtProt PhosphoSitePlus Signor	20802513
Q05397 (PTK2)	Y194	score3	neXtProt PhosphoSitePlus Signor	20802513
Q05655 (PRKCD)	Y313	score2	neXtProt	17956904
Q05655 (PRKCD)	Y334	score2	neXtProt	17956904
Q13315 (ATM)	Y370	score2	PhosphoSitePlus	25601159
Q13480 (GAB1)	Y285	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10734310, 9890893
Q13480-1 (GAB1)	Y307	score4	HPRD phospho.ELM	10734310, 16497976
Q13480 (GAB1)	Y373	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10978177, 16497976, 17389395, ...9890893
Q13480-2 (GAB1)	Y406	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	17016520, 19901323, 17389395, ...9890893, 10734310, 16497976
Q13480-2 (GAB1)	Y447	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10734310, 9890893
Q13480 (GAB1)	Y472	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10734310, 9890893
Q13480 (GAB1)	Y589	score4	HPRD phospho.ELM PhosphoSitePlus Signor	10734310, 9890893
Q13480-2 (GAB1)	Y619	score4	HPRD neXtProt	10734310, 9890893
Q13480 (GAB1)	Y627	score4	HPRD phospho.ELM PhosphoSitePlus Signor	17016520, 10734310, 17389395, ...20068231, 9890893
Q13480-2 (GAB1)	Y657	score4	HPRD neXtProt	17016520, 10734310, 17389395, ...20068231, 9890893
Q13480 (GAB1)	Y659	score4	HPRD phospho.ELM PhosphoSitePlus Signor	16497976, 10734310, 18669648, ...17389395, 9890893
Q13480-2 (GAB1)	Y689	score4	HPRD neXtProt	16497976, 10734310, 18669648, ...17389395, 9890893
Q14457 (BECN1)	Y229	score2	PhosphoSitePlus	24034250
Q14457 (BECN1)	Y233	score2	PhosphoSitePlus	24034250
Q14457 (BECN1)	Y352	score2	PhosphoSitePlus	24034250
Q15645 (TRIP13)	Y56	score1	Signor	32860853
Q38SD2 (LRRK1)	Y971	score3	neXtProt PhosphoSitePlus	22337768
Q8IVM0 (CCDC50)	Y217	score3	neXtProt PhosphoSitePlus Signor	19059208
Q8IVM0 (CCDC50)	Y279	score3	neXtProt PhosphoSitePlus Signor	19059208
Q8IVM0 (CCDC50)	Y304	score3	neXtProt PhosphoSitePlus Signor	19059208
Q8NFJ5 (GPRC5A)	Y317	score2	PhosphoSitePlus	25311788
Q8NFJ5 (GPRC5A)	Y320	score2	PhosphoSitePlus	25311788
Q8NFJ5 (GPRC5A)	Y347	score2	PhosphoSitePlus	25311788
Q8NFJ5 (GPRC5A)	Y350	score2	PhosphoSitePlus	25311788
Q8TDY4 (ASAP3)	Y34	score3	PhosphoSitePlus Signor	23776207
Q92529-2 (SHC3)	Y218	score3	neXtProt PhosphoSitePlus	11791173
Q92529-2 (SHC3)	Y219	score3	neXtProt PhosphoSitePlus	11791173
Q92529-2 (SHC3)	Y256	score3	neXtProt PhosphoSitePlus	11791173
Q92529-2 (SHC3)	Y257	score3	neXtProt PhosphoSitePlus	11791173
Q92529-2 (SHC3)	Y283	score3	neXtProt PhosphoSitePlus	11791173
Q92529-2 (SHC3)	Y301	score3	neXtProt PhosphoSitePlus	11791173
Q92952 (KCNN1)	Y109	score2	PhosphoSitePlus	23496660
Q96TA1 (NIBAN2)	Y593	score2	PhosphoSitePlus	26721396
Q9P0J1 (PDP1)	Y381	score2	PhosphoSitePlus	24486017
Q9UBN7 (HDAC6)	Y570	score3	neXtProt PhosphoSitePlus Signor	20029029
Q9UK17 (KCND3)	Y136	score2	PhosphoSitePlus	22198508
Q9UKV8 (AGO2)	Y393	score2	PhosphoSitePlus	23636329

Proteoforms

PRO ID (Short Label)	Sites	Source	PMID
PR:000047261 (hEGFR/SigPep-/Phos:1)	pY1092,pY1110,pY1172,pY1197	PRO
PR:000047262 (hEGFR/SigPep-/Phos:2)	pY1016,pY1069,pY1092,pY1110,pY1172,pY1197	PRO
PR:000027479 (hEGFR/iso:1/SigPep-/Phos:1)	pY869	PRO	18789131
PR:000049849 (hEGFR/SigPep-/Phos:3)	pS1070,pS1071,pS1081,pS1166	PRO	10347170
PR:000049851 (hEGFR/SigPep-/Phos:4)	pS768	PRO	10347170

PTM-dependent PPI

PTM type	Substrate	Site	Interactant	Association type	Source	PMID
Phosphorylation	O43707 (ACTN4)	Y31	P00533 (EGFR)	unknown	eFIP	33532643
Phosphorylation	P00533 (EGFR)	S1071	P22681 (CBL)	increased_association	eFIP	20877636
Phosphorylation	P04626 (ERBB2)	Y1248	P00533 (EGFR)	unknown	eFIP	15163624
Phosphorylation	P04626 (ERBB2)	T701	P00533 (EGFR)	unknown	eFIP	28632938
Phosphorylation	P14618 (PKM)	S37	P00533 (EGFR)	unknown	eFIP	23178880
Phosphorylation	P15311 (EZR)	Y146	P00533 (EGFR)	unknown	eFIP	26936397
Phosphorylation	P29317 (EPHA2)	S897	P00533 (EGFR)	increased_association	eFIP	35668076
Phosphorylation	P35568 (IRS1)	Y612	P00533 (EGFR)	increased_association	eFIP	17902048
Phosphorylation	P35790 (CHKA)	Y333	P00533 (EGFR)	unknown	eFIP	21822308
Phosphorylation	P46108 (CRK)	Y221	P00533 (EGFR)	unknown	eFIP	10595738
Phosphorylation	P78527 (PRKDC)	T2609	P00533 (EGFR)	inhibited_association	eFIP	22923485
Phosphorylation	Q13547 (HDAC1)	Y72	P00533 (EGFR)	unknown	eFIP	33976119
Phosphorylation	Q9UJM3 (ERRFI1)	Y394	P00533 (EGFR)	unknown	eFIP	26280531

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:000049849 (hEGFR/SigPep-/Phos:3)	decreased Interaction	PR:P00533 (hEGFR)	PRO	10347170

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K37	N37	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y117	C117	Biomuta	DOID:3571 / liver cancer [ cosmic ]
N175	D175	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
R222	C222	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ cosmic, icgc, tcga ]
R222	L222	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R222	H222	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
R224	H224	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
R224	C224	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S229	N229	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S229	C229	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
C311	F311	Biomuta	DOID:1324 / lung cancer [ cosmic ]
C311	S311	Biomuta	DOID:1319 / brain cancer [ cosmic ]
C311	R311	Biomuta	DOID:1319 / brain cancer [ cosmic ]
C311	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
C329	Y329	Biomuta	DOID:4362 / cervical cancer [ icgc ]
T354	M354	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S364	F364	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S380	F380	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
N413	K413	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T430	I430	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S437	Y437	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S442	R442	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S442	I442	Biomuta	DOID:1324 / lung cancer [ cosmic ]
N444	I444	Biomuta	DOID:1319 / brain cancer [ cosmic ]
N444	S444	Biomuta	DOID:363 / uterine cancer [ icgc ]
S511	Y511	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
N603	K603	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
N623	H623	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
N623	Y623	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S645	C645	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
S645	F645	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T678	M678	Biomuta	DOID:363 / uterine cancer [ icgc ]
T693	A693	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S695	G695	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
K708	R708	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
K708	E708	Biomuta	DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K708	M708	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K714	N714	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K714	E714	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K714	T714	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
K716	R716	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
K716	E716	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S720	P720	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S720	T720	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S720	C720	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S720	F720	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T725	A725	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
T725	M725	Biomuta	DOID:4606 / bile duct cancer [ cosmic ] DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y727	C727	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K728	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K737	E737	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K737	R737	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K745	R745	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
K745	T745	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S752	F752	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S752	Y752	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S752	P752	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K754	I754	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
K754	E754	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
K754	R754	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K754	A754	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K757	R757	Biomuta	DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ civic, cosmic ]
K757	M757	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S768	G768	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S768	N768	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S768	I768	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ civic, cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S768	T768	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T790	M790	Biomuta	[ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ civic, cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1793 / pancreatic cancer [ civic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T790	A790	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
T790	S790	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y801	H801	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
Y801	C801	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y827	*	Biomuta	DOID:363 / uterine cancer [ cosmic ]
V845	E845	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
V845	A845	Biomuta	DOID:1324 / lung cancer [ cosmic ]
V845	M845	Biomuta	DOID:3953 / adrenal gland cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K846	R846	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K852	N852	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
K852	T852	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K852	R852	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K860	I860	Biomuta	DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K867	T867	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y869	C869	Biomuta	DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K875	R875	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
Y891	C891	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
Y915	C915	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
Y915	H915	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T940	A940	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y944	C944	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
Y1016	N1016	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S1028	L1028	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T1032	S1032	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1036	R1036	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
T1041	A1041	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S1042	N1042	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S1045	F1045	Biomuta	[ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1064	R1064	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S1064	N1064	Biomuta	[ cosmic ]
S1064	G1064	Biomuta	DOID:1612 / breast cancer [ cosmic ]
Y1069	C1069	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S1070	T1070	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T1078	I1078	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1096	F1096	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1110	F1110	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1120	N1120	Biomuta	[ cosmic ]
S1130	G1130	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S1130	R1130	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y1138	C1138	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T1150	S1150	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S1153	I1153	Biomuta	DOID:3571 / liver cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S1153	N1153	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S1162	C1162	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S1162	N1162	Biomuta	DOID:1319 / brain cancer [ cosmic ]
K1182	N1182	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
K1188	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K1188	E1188	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K1188	T1188	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S1190	P1190	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y1197	C1197	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
R1199	M1199	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R1199	T1199	Biomuta	DOID:263 / kidney cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P00533 (EGFR)

Protein Information

Interactive Sequence View

P00533 (EGFR) as Substrate

P00533 (EGFR) as PTM Enzyme

Proteoforms

PTM-dependent PPI

Proteoform PPIs

PTM sites affected in variants