iPTMnet Report O96020 CCNE2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O96020 / CCNE2_HUMAN
Protein Name	G1/S-specific cyclin-E2
Gene Name	Name: CCNE2
Organism	Homo sapiens (Human)

PRO ID	PR:O96020 DAG View
PRO Name	G1/S-specific cyclin-E2 (human)
Definition	A G1/S-specific cyclin-E2 that is encoded in the genome of human.
Short Label	hCCNE2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O96020 (CCNE2) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S17	Phosphorylation		score1	PhosphoSitePlus
	T19	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
	S21	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 19690332
	K31	Ubiquitination		score1	PhosphoSitePlus
	T35	O-Glycosylation		score1	GlyGen	30620550
	T36	O-Glycosylation		score1	GlyGen	30620550
	K49	Ubiquitination		score1	PhosphoSitePlus
	S67	Phosphorylation		score1	PhosphoSitePlus
	T74	Phosphorylation		score1	PhosphoSitePlus
	S339	Phosphorylation		score1	PhosphoSitePlus
	S383	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
	T392	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18691976, 9840943, 19084516
	S396	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	19084516

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T19	Phosphorylation		score0	HPRD	18669648
	S21	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...20068231
	S63	Phosphorylation		score0	HPRD	18691976
	S383	Phosphorylation		score0	HPRD	18691976
	T392	Phosphorylation		score2	HPRD	18691976, 9840943
	S396	Phosphorylation		score0	HPRD	18691976

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T19	M19	Biomuta		DOID:184 / bone cancer [ cosmic ]
T19	A19	Biomuta		DOID:1319 / brain cancer [ cosmic, icgc ]
S21	F21	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S67	G67	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
T392	R392	Biomuta		DOID:1319 / brain cancer [ cosmic ]