iPTMnet Report for O96017 (CHEK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O96017 / CHK2_HUMAN
Protein Name Serine/threonine-protein kinase Chk2
Gene Name Name: CHEK2
Synonyms:CDS1,CHK2,RAD53;
Organism Homo sapiens (Human)

PRO ID PR:O96017
DAG View
PRO Name serine/threonine-protein kinase Chk2 (human)
Definition A serine/threonine-protein kinase Chk2 that is encoded in the genome of human.
Short Label hCHEK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O96017 (CHEK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   RLIMS-P 20542099, 14970866, 12637545, ...15322239, 17653574, 17940507
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19390600, 30273361, 25535901, ...17363488, 16940182, 10973490, 20713355, 22808196, 18812180, 18538787
S19 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
S19 Phosphorylation Q13315 (ATM) phospho.ELM   Signor 10973490
S24 Phosphorylation PhosphoSitePlus
T26 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12024051, 12493754, 10973490
T26 Phosphorylation P53350 (PLK1) phospho.ELM 12493754
T26 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 12024051, 10973490
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10973490, 12493754, 12024051
S28 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 10973490, 12024051
S33 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25535901, 17363488, 20160490, ...10973490, 20713355, 14695167, 16940182, 18538787
S33 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
S33 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 10973490, 14695167
S35 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25535901, 17363488, 20160490, ...10973490, 20713355, 14695167, 16940182, 18538787
S35 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
S35 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 10973490, 14695167
S39 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 10973490
S50 Phosphorylation Q13315 (ATM) phospho.ELM   Signor 10973490
S52 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S62 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16481012, 12242661, 21376736
S62 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus 16481012, 12242661, 21376736
T65 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
T68 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23690919, 31269698, 12493754, ...18948271, 24415942, 16481012, 15361851, 27888802, 11901158, 17940507, 16461339, 30054569, 22170260, 21310354, 28535155, 32752095, 25111195, 31759252, 24553354, 27991505, 30337689, 31777420, 17513615, 15048074, 21765476, 19798429, 19001859, 29340034, 26431963, 12386164, 32432260, 15533933, 23383325, 16741947, 20424615, 23977391, 20126263, 28049532, 33500399, 24190430, 26441204, 22099307, 21338495, 15876876, 29563987, 22623962, 29643855, 17671118, 24492479, 16794575, 12607004, 20637859, 15322239, 30272263, 15700044, 12024051, 35999268, 35663228, 15342622, 18762365, 18985806, 12242661, 19658174, 20305300, 19451272, 26333122, 12637545, 16024600, 24153426, 18957425, 26333361, 20713355, 28103869, 26751069, 20637980, 28967905, 25527123, 16705183, 15668230, 26714930, 21102523, 22312557, 32883962, 15618221, 23598415, 28259974, 26158765, 19390600, 25895498, 10744722, 28852018, 24798733, 24882580, 27125496, 18787700, 15784679, 22589537, 15963507, 11390408, 30516086, 16150728, 21390062, 28539821, 30245854, 23013471, 32942996, 21772273, 28094252, 10973490, 17715138, 16940182, 27767095, 16596250, 16322218, 24792164, 19782031, 11025670, 19330022, 32479542, 26416514, 19377277, 30900384, 21147465, 19151762, 30473536, 29399146, 27029031, 15140942, 27076856, 20599567, 30483783, 20406977, 18644861, 25886177, 24844881, 29741650, 26542114, 12805407, 19411857, 16311512, 26919204, 25875766, 16478990, 29062040, 24758542, 24498068, 31209362, 15213307, 16456034, 25535901, 28038466, 18812180, 16982735, 17236549, 23705030, 11668173, 33968195, 29444163, 11085506, 30304835, 31911943, 16798742, 26485758, 12447382, 26442630, 24812435, 11096068, 21624128, 17363488, 17685927, 33607997, 23666059, 32741974, 14695167, 11053450
T68 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor 12024051, 18644861, 11901158, ...16150728, 12805407
T68 Phosphorylation P33981 (TTK) phospho.ELM   PhosphoSitePlus   Signor 15618221
T68 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   Signor 20126263, 12493754
T68 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   Signor 15668230
T68 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11390408, 11096068, 10744722, ...20305300, 11025670, 11085506, 15533933, 12637545, 15322239, 11668173, 10973490, 14695167, 16478990, 16940182, 22099307
T68 Phosphorylation Q13535 (ATR) PhosphoSitePlus   Signor 10973490, 15533933
T68 Phosphorylation Q683Z8 (CHK2) phospho.ELM 11901158
T68 Phosphorylation Q9NYL2 (MAP3K20) PhosphoSitePlus 15342622
S73 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16481012, 12242661, 21376736
S73 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus 16481012, 12242661, 21376736
K119 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus 18538787
S120 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
K131 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus 18948271
S140 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18948271
Y156 Phosphorylation PhosphoSitePlus   RLIMS-P 35851582
S164 Phosphorylation PhosphoSitePlus 20126263
S164 Phosphorylation P53350 (PLK1) PhosphoSitePlus 20126263
T205 Phosphorylation PhosphoSitePlus   RLIMS-P 20126263
T205 Phosphorylation P53350 (PLK1) PhosphoSitePlus 20126263
S210 Phosphorylation PhosphoSitePlus   RLIMS-P 20126263
S210 Phosphorylation P53350 (PLK1) PhosphoSitePlus 20126263
K224 Ubiquitination PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus 18538787
T225 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
K235 Acetylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus 18538787
S260 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
K279 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S357 Phosphorylation neXtProt 10973490
S357 Phosphorylation Q13315 (ATM) neXtProt 10973490
S372 Phosphorylation PhosphoSitePlus   RLIMS-P 20713355
K373 Ubiquitination PhosphoSitePlus
T378 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35132862, 33690219
T378 Phosphorylation PhosphoSitePlus   RLIMS-P 20713355
S379 Phosphorylation neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18644861, 20713355, 18538787
S379 Phosphorylation O96017 (CHEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 18644861, 18538787
T383 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11390408, 12805407, 18644861, ...24798733, 15668230, 11901158, 20713355
T383 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor   UniProt 12805407, 11390408, 11901158, ...18644861
T383 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 15668230
T383 Phosphorylation Q683Z8 (CHK2) phospho.ELM 11390408
T387 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31209362, 16941491, 12805407, ...18644861, 11390408, 15668230, 11901158, 15361830, 20713355, 26158765
T387 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor   UniProt 12805407, 11390408, 11901158, ...18644861
T387 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 15668230
T387 Phosphorylation Q683Z8 (CHK2) phospho.ELM 11390408
T389 Phosphorylation PhosphoSitePlus   RLIMS-P 20713355
Y390 Phosphorylation PhosphoSitePlus   RLIMS-P 20713355
S428 Phosphorylation RLIMS-P 18787700
T432 Phosphorylation PhosphoSitePlus   RLIMS-P 31209362, 18538787
T432 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
S435 Phosphorylation PhosphoSitePlus 18538787
S435 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 18538787
K437 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S456 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26751770, 17715138
K458 Ubiquitination PhosphoSitePlus
K472 Methylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 21239475, 22004065, 12805407, ...18644861, 33607997, 12855706, 23855452, 20713355, 18538787
S516 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor 12805407, 12855706, 18644861, ...18538787
S516 Phosphorylation Q683Z8 (CHK2) phospho.ELM 12805407
T517 Phosphorylation PhosphoSitePlus
K520 Phosphorylation PhosphoSitePlus
C539 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 10973490
S19 Phosphorylation Q13315 (ATM) HPRD 10973490
S19 Phosphorylation Q13535 (ATR) HPRD 10973490
T26 Phosphorylation HPRD 10973490, 12493754, 12024051
T26 Phosphorylation P53350 (PLK1) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13315 (ATM) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13535 (ATR) HPRD 10973490, 12493754, 12024051
S28 Phosphorylation HPRD 10973490, 12024051
S28 Phosphorylation Q13315 (ATM) HPRD 10973490, 12024051
S28 Phosphorylation Q13535 (ATR) HPRD 10973490, 12024051
S33 Phosphorylation HPRD 10973490
S33 Phosphorylation Q13315 (ATM) HPRD 10973490
S33 Phosphorylation Q13535 (ATR) HPRD 10973490
S35 Phosphorylation HPRD 10973490
S35 Phosphorylation Q13315 (ATM) HPRD 10973490
S35 Phosphorylation Q13535 (ATR) HPRD 10973490
S50 Phosphorylation HPRD 10973490
S50 Phosphorylation Q13315 (ATM) HPRD 10973490
S50 Phosphorylation Q13535 (ATR) HPRD 10973490
T68 Phosphorylation HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation O96017 (CHEK2) HPRD 10973490, 11901158, 12493754, ...12242661
T68 Phosphorylation P53350 (PLK1) HPRD 10973490, 11901158, 12493754, ...12242661
T68 Phosphorylation Q13315 (ATM) HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation Q9H4B4 (PLK3) HPRD 10973490, 11901158, 12493754, ...12242661
T383 Phosphorylation HPRD 11390408
T383 Phosphorylation O96017 (CHEK2) HPRD 11390408
T387 Phosphorylation HPRD 11390408
T387 Phosphorylation O96017 (CHEK2) HPRD 11390408
S516 Phosphorylation HPRD 12805407, 11390408
S516 Phosphorylation O96017 (CHEK2) HPRD 12805407, 11390408
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 10973490
S19 Phosphorylation Q13315 (ATM) HPRD 10973490
S19 Phosphorylation Q13535 (ATR) HPRD 10973490
T26 Phosphorylation HPRD 10973490, 12493754, 12024051
T26 Phosphorylation P53350 (PLK1) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13315 (ATM) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13535 (ATR) HPRD 10973490, 12493754, 12024051
S28 Phosphorylation HPRD 10973490, 12024051
S28 Phosphorylation Q13315 (ATM) HPRD 10973490, 12024051
S28 Phosphorylation Q13535 (ATR) HPRD 10973490, 12024051
S33 Phosphorylation HPRD 10973490
S33 Phosphorylation Q13315 (ATM) HPRD 10973490
S33 Phosphorylation Q13535 (ATR) HPRD 10973490
S35 Phosphorylation HPRD 10973490
S35 Phosphorylation Q13315 (ATM) HPRD 10973490
S35 Phosphorylation Q13535 (ATR) HPRD 10973490
S50 Phosphorylation HPRD 10973490
S50 Phosphorylation Q13315 (ATM) HPRD 10973490
S50 Phosphorylation Q13535 (ATR) HPRD 10973490
T68 Phosphorylation HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation O96017 (CHEK2) HPRD 10973490, 11901158, 12493754, ...12242661
T68 Phosphorylation P53350 (PLK1) HPRD 10973490, 11901158, 12493754, ...12242661
T68 Phosphorylation Q13315 (ATM) HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation Q9H4B4 (PLK3) HPRD 10973490, 11901158, 12493754, ...12242661
T354 Phosphorylation HPRD 11390408
T354 Phosphorylation O96017 (CHEK2) HPRD 11390408
T358 Phosphorylation HPRD 11390408
T358 Phosphorylation O96017 (CHEK2) HPRD 11390408
S487 Phosphorylation HPRD 12805407, 11390408
S487 Phosphorylation O96017 (CHEK2) HPRD 12805407, 11390408
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 10973490
S19 Phosphorylation Q13315 (ATM) HPRD 10973490
S19 Phosphorylation Q13535 (ATR) HPRD 10973490
T26 Phosphorylation HPRD 10973490, 12493754, 12024051
T26 Phosphorylation P53350 (PLK1) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13315 (ATM) HPRD 10973490, 12493754, 12024051
T26 Phosphorylation Q13535 (ATR) HPRD 10973490, 12493754, 12024051
S28 Phosphorylation HPRD 10973490, 12024051
S28 Phosphorylation Q13315 (ATM) HPRD 10973490, 12024051
S28 Phosphorylation Q13535 (ATR) HPRD 10973490, 12024051
S33 Phosphorylation HPRD 10973490
S33 Phosphorylation Q13315 (ATM) HPRD 10973490
S33 Phosphorylation Q13535 (ATR) HPRD 10973490
S35 Phosphorylation HPRD 10973490
S35 Phosphorylation Q13315 (ATM) HPRD 10973490
S35 Phosphorylation Q13535 (ATR) HPRD 10973490
S50 Phosphorylation HPRD 10973490
S50 Phosphorylation Q13315 (ATM) HPRD 10973490
S50 Phosphorylation Q13535 (ATR) HPRD 10973490
T68 Phosphorylation HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation P53350 (PLK1) HPRD 10973490, 11901158, 12493754, ...12242661
T68 Phosphorylation Q13315 (ATM) HPRD 16794575, 10973490, 11901158, ...12493754, 12242661
T68 Phosphorylation Q9H4B4 (PLK3) HPRD 10973490, 11901158, 12493754, ...12242661
T426 Phosphorylation HPRD 11390408
T426 Phosphorylation O96017 (CHEK2) HPRD 11390408
T430 Phosphorylation HPRD 11390408
T430 Phosphorylation O96017 (CHEK2) HPRD 11390408
S559 Phosphorylation HPRD 12805407, 11390408
S559 Phosphorylation O96017 (CHEK2) HPRD 12805407, 11390408


O96017 (CHEK2) as PTM Enzyme



Substrate Site Score Source PMID
O00716 (E2F3) S124 PhosphoSitePlus 19917728
O15151 (MDM4) S342 HPRD   PhosphoSitePlus   Signor 16943424, 16163388
O15151 (MDM4) S367 HPRD   PhosphoSitePlus   Signor 16943424, 18356162, 16163388, ...16511560
O43255 (SIAH2) T26 PhosphoSitePlus 26751770
O43255 (SIAH2) S28 PhosphoSitePlus 26751770
O43255 (SIAH2) S68 PhosphoSitePlus 26751770
O43255 (SIAH2) T119 PhosphoSitePlus 26751770
O60673 (REV3L) S1075 PhosphoSitePlus 18622427
O96017 (CHEK2) S19 PhosphoSitePlus 18538787
O96017 (CHEK2) S33 PhosphoSitePlus 18538787
O96017 (CHEK2) S35 PhosphoSitePlus 18538787
O96017-1 (CHEK2) T68 HPRD   PhosphoSitePlus   Signor 12242661, 12493754, 16150728, ...12805407, 18644861, 12024051, 11901158, 10973490
O96017 (CHEK2) S120 PhosphoSitePlus 18538787
O96017 (CHEK2) S140 PhosphoSitePlus 18948271
O96017 (CHEK2) T225 PhosphoSitePlus 18538787
O96017 (CHEK2) S260 PhosphoSitePlus 18538787
O96017-12 (CHEK2) T354 HPRD 11390408
O96017-12 (CHEK2) T358 HPRD 11390408
O96017 (CHEK2) S379 neXtProt   PhosphoSitePlus   Signor   UniProt 18644861, 18538787
O96017 (CHEK2) T383 HPRD   PhosphoSitePlus   Signor   UniProt 12805407, 11390408, 11901158, ...18644861
O96017 (CHEK2) T387 HPRD   PhosphoSitePlus   Signor   UniProt 12805407, 11390408, 11901158, ...18644861
O96017-9 (CHEK2) T426 HPRD 11390408
O96017-9 (CHEK2) T430 HPRD 11390408
O96017 (CHEK2) T432 PhosphoSitePlus 18538787
O96017 (CHEK2) S435 PhosphoSitePlus 18538787
O96017-12 (CHEK2) S487 HPRD 12805407, 11390408
O96017 (CHEK2) S516 HPRD   PhosphoSitePlus   Signor 12805407, 12855706, 11390408, ...18644861, 18538787
O96017-9 (CHEK2) S559 HPRD 12805407, 11390408
P04637 (TP53) S15 PhosphoSitePlus   Signor 17339337, 10673501, 10710310, ...10656682
P04637 (TP53) T18 PhosphoSitePlus   Signor 17339337, 10673501, 10710310, ...10656682
P04637 (TP53) S20 PhosphoSitePlus   Signor 17339337, 10673500, 10801407, ...10710310, 10673501
P04637 (TP53) S37 PhosphoSitePlus   Signor 10673501, 10710310, 10656682, ...15659650
P04637 (TP53) S366 PhosphoSitePlus   Signor 10673501, 15659650
P04637 (TP53) S378 PhosphoSitePlus   Signor 17339337, 10710310, 15659650
P06400 (RB1) S612 neXtProt   PhosphoSitePlus   Signor 17380128
P10636-8 (MAPT) S262 PhosphoSitePlus 20159774
P10636 (MAPT) S579 Signor 21215781
P16403 (H1-2) S36 PhosphoSitePlus 17877366
P16403 (H1-2) S55 PhosphoSitePlus 17877366
P16403 (H1-2) S89 PhosphoSitePlus 17877366
P16403 (H1-2) T92 PhosphoSitePlus 17877366
P16403 (H1-2) T167 PhosphoSitePlus 17877366
P18887 (XRCC1) S184 PhosphoSitePlus 18971944
P18887 (XRCC1) S210 PhosphoSitePlus 18971944
P18887 (XRCC1) T284 PhosphoSitePlus   Signor 18971944
P21127 (CDK11B) S752 PhosphoSitePlus 23178491
P23560 (BDNF) T62 PhosphoSitePlus 23712400
P29590-3 (PML) S117 PhosphoSitePlus   Signor 12402044
P30304 (CDC25A) S124 PhosphoSitePlus   Signor 11298456, 12676583
P30304 (CDC25A) S178 HPRD   PhosphoSitePlus   Signor 12676583, 14559997
P30304-2 (CDC25A) S239 HPRD 12676583
P30304-2 (CDC25A) S253 HPRD 12676583
P30304 (CDC25A) S279 HPRD   PhosphoSitePlus   Signor 12676583
P30304 (CDC25A) S293 HPRD   PhosphoSitePlus   Signor 12676583
P30307 (CDC25C) S216 HPRD   neXtProt   PhosphoSitePlus   Signor 12835754, 10097108, 10744722, ...9543386, 16481012, 9836640, 10557092, 9278512, 16794575, 11333986, 11551930, 10786669, 20068231
P33981 (TTK) T288 PhosphoSitePlus   Signor 19151762, 24764296
P38398-8 (BRCA1) S941 HPRD 10724175
P38398 (BRCA1) S988 HPRD   PhosphoSitePlus   Signor 14701743, 10724175, 12111733
P40337 (VHL) S111 PhosphoSitePlus   Signor 22071692
P54132 (BLM) T182 PhosphoSitePlus 26028025
P61289 (PSME3) S247 PhosphoSitePlus   Signor 25361978
Q01094 (E2F1) S364 HPRD   PhosphoSitePlus   Signor 22558186, 12717439
Q08050-2 (FOXM1) S361 PhosphoSitePlus 17101782
Q08050 (FOXM1) S376 neXtProt   Signor 17101782
Q13263 (TRIM28) S473 PhosphoSitePlus 22715096, 22491012
Q13972 (RASGRF1) S287 Signor 17110335
Q14457 (BECN1) S90 Signor 32187724
Q14457 (BECN1) S93 Signor 32187724
Q15717 (ELAVL1) S88 PhosphoSitePlus 17317627, 21745814
Q15717 (ELAVL1) S100 PhosphoSitePlus 17317627, 21745814
Q15717 (ELAVL1) T118 PhosphoSitePlus 17317627, 21745814
Q9NRM7 (LATS2) S172 neXtProt   PhosphoSitePlus 21118956
Q9NRM7 (LATS2) S380 neXtProt   PhosphoSitePlus 21118956
Q9NRM7 (LATS2) S408 neXtProt   PhosphoSitePlus 21118956
Q9NRM7 (LATS2) S446 neXtProt   PhosphoSitePlus 21118956
Q9NY61 (AATF) S141 HPRD 17157788
Q9NY61 (AATF) S143 PhosphoSitePlus   Signor 17157788
Q9NY61 (AATF) S477 PhosphoSitePlus   Signor 17157788
Q9NY61 (AATF) S510 PhosphoSitePlus   Signor 17157788
Q9UQ88 (CDK11A) S740 neXtProt 23178491


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046702 (hCHEK2/Phos:2) pT68,pS379,pT383,pT387 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O96017 (CHEK2) T68 P28482 (MAPK1) unknown eFIP 21772273
Phosphorylation P04049 (RAF1) S338 O96017 (CHEK2) unknown eFIP 26333361


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P29590-5 (hPML/iso:5) Interaction PR:O96017 (hCHEK2) PRO 12402044


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S19 L19 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S24 C24 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S42 C42 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T45 M45 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S50 N50 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S50 T50 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S52 P52 Biomuta DOID:1324 / lung cancer [ cosmic ]
T65 A65 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S120 C120 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S164 N164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T205 I205 Biomuta [ cosmic ]
S210 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K235 E235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K235 Q235 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K279 N279 Biomuta [ cosmic ]
K279 T279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S372 F372 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S372 C372 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K373 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K373 N373 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K373 E373 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:363 / uterine cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T378 A378 Biomuta DOID:363 / uterine cancer [ icgc ]
S379 F379 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S379 C379 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y390 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y390 D390 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y390 C390 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y390 N390 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S428 F428 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K437 Q437 Biomuta DOID:3565 / meningioma [ cosmic ]
S456 * Biomuta DOID:5158 / pleural cancer [ cosmic ]
S456 L456 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K472 N472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K494 M494 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]