iPTMnet Report for O96006 (ZBED1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O96006 / ZBED1_HUMAN
Protein Name E3 SUMO-protein ligase ZBED1
Gene Name Name: ZBED1
Synonyms:ALTE,DREF;
Organism Homo sapiens (Human)

PRO ID PR:O96006
DAG View
PRO Name E3 SUMO-protein ligase ZBED1 (human)
Definition An E3 SUMO-protein ligase ZBED1 that is encoded in the genome of human.
Short Label hZBED1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O96006 (ZBED1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y167 Phosphorylation HPRD   PhosphoSitePlus 19664994
T170 Phosphorylation HPRD   PhosphoSitePlus 19664994
K171 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
C290 Methylation IEDB 31844290
K317 Acetylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K96 M96 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K113 R113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y167 H167 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T170 N170 Biomuta DOID:4159 / skin cancer [ icgc ]
K176 N176 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T212 M212 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K502 R502 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K509 N509 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T537 P537 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T537 M537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K632 N632 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]