Protein Information

Cytoscape View


UniProt AC / UniProt ID O95278 / EPM2A_HUMAN
Protein Name Laforin
Gene Name Name: EPM2A
Organism Homo sapiens (Human)

PRO ID PR:O95278
DAG View
PRO Name laforin isoforms 1/2/4/5/6/7/8 (human)
Definition A laforin (human), isoforms 1, 2, 4, 5, 6, 7, and 8.
Short Label hEPM2A/iso:[1/2/4/5/6/7/8]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


O95278 (EPM2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S25 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P   UniProt 21728993
Y304 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
R325 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S147 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95278 (EPM2A) S25 Q6VVB1 (NHLRC1) unknown eFIP 21728993


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R325 C325 Biomuta DOID:1909 / melanoma [ tcga ]