iPTMnet Report for O95208 (EPN2)
Protein Information
| UniProt AC / UniProt ID | O95208 / EPN2_HUMAN |
| Protein Name | Epsin-2 |
| Gene Name | Name: EPN2 Synonyms:KIAA1065; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95208 |
| PRO Name | epsin-2 (human) |
| Definition | An epsin-2 that is encoded in the genome of human. |
| Short Label | hEPN2 |
| Category | organism-gene |
O95208 (EPN2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K11 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y83 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K135 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T150 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R153 | Phosphorylation | score1 | UniProt | 21406692, 17081983, 24275569 | ||
| Q156 | Phosphorylation | score1 | UniProt | 21406692 | ||
| S163 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R170 | Methylation | score1 | PhosphoSitePlus | |||
| S172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S173 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S180 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 17081983, 24275569 | ||
| S195 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S237 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T272 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S273 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S287 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S327 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S408 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S420 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K423 | Acetylation | score1 | PhosphoSitePlus | |||
| K423 | Methylation | score1 | PhosphoSitePlus | |||
| K423 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S426 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S486 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S492 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S504 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T508 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S511 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S570 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S578 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S622 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S628 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Y83 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S172 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S173 | Phosphorylation | score0 | HPRD | 15345747 | ||
| S182 | Phosphorylation | score0 | HPRD | 15345747 | ||
| S492 | Phosphorylation | score0 | HPRD | 19413330 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Y83 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S172 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S173 | Phosphorylation | score0 | HPRD | 15345747 | ||
| S182 | Phosphorylation | score0 | HPRD | 15345747 | ||
| Y186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K188 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19651622, 17081983, 20068231, ... | ||
| S195 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19651622, 17081983, 20068231 | ||
| Y196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T200 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S201 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S435 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S4 | L4 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K69 | T69 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K107 | N107 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| R153 | L153 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S182 | P182 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| Y186 | N186 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| S199 | L199 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S201 | T201 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T259 | R259 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T316 | R316 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S327 | C327 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S408 | L408 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| K423 | N423 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
DAG View