Protein Information

Cytoscape View


UniProt AC / UniProt ID O95208 / EPN2_HUMAN
Protein Name Epsin-2
Gene Name Name: EPN2
Synonyms:KIAA1065;
Organism Homo sapiens (Human)

PRO ID PR:O95208
DAG View
PRO Name epsin-2 (human)
Definition An epsin-2 that is encoded in the genome of human.
Short Label hEPN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95208 (EPN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
R170 Methylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus   UniProt 23186163
S178 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K423 Acetylation PhosphoSitePlus
K423 Methylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus   UniProt 24275569
S578 O-Glycosylation GlyGen 30459171
S622 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y83 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 18452278
S173 Phosphorylation HPRD 15345747
S182 Phosphorylation HPRD 15345747
S492 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
Y83 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 18452278
S173 Phosphorylation HPRD 15345747
S182 Phosphorylation HPRD 15345747
Y186 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S192 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...19664995
S195 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
Y196 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
S435 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 L4 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S5 C5 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
K69 T69 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K107 N107 Biomuta DOID:363 / uterine cancer [ tcga ]
R170 * Biomuta DOID:1319 / brain cancer [ icgc ]
S199 L199 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]