iPTMnet Report for O94900 (TOX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94900 / TOX_HUMAN
Protein Name Thymocyte selection-associated high mobility group box protein TOX
Gene Name Name: TOX
Synonyms:KIAA0808;
Organism Homo sapiens (Human)

PRO ID PR:O94900
DAG View
PRO Name thymocyte selection-associated high mobility group box protein TOX (human)
Definition A thymocyte selection-associated high mobility group box protein TOX that is encoded in the genome of human.
Short Label hTOX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94900 (TOX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S336 O-Glycosylation GlyGen 35132862, 28657654, 35254053
S336 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
S338 O-Glycosylation GlyGen 35132862, 28657654, 35254053
S338 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S346 O-Glycosylation GlyGen 35132862, 28657654, 35254053
Y492 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S216 P216 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K245 E245 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K246 N246 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K280 N280 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y337 C337 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K344 N344 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S513 T513 Biomuta DOID:1324 / lung cancer [ cosmic ]
T526 A526 Biomuta DOID:5041 / esophageal cancer [ cosmic ]