iPTMnet Report for O94808 (GFPT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94808 / GFPT2_HUMAN
Protein Name Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Gene Name Name: GFPT2
Organism Homo sapiens (Human)

PRO ID PR:O94808
DAG View
PRO Name glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (human)
Definition A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 that is encoded in the genome of human.
Short Label hGFPT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94808 (GFPT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 15133036
T227 Phosphorylation PhosphoSitePlus
S244 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18767875, 18669648, 23186163
S245 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18767875, 17081983
K254 Acetylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
C375 Methylation IEDB 31844290
T444 Phosphorylation PhosphoSitePlus
C461 Methylation IEDB 31844290
K602 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
Y667 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S202 I202 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S202 R202 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S244 I244 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y667 D667 Biomuta DOID:1324 / lung cancer [ cosmic ]
S678 Y678 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]