iPTMnet Report for O94761 (RECQL4)
Protein Information
UniProt AC / UniProt ID | O94761 / RECQ4_HUMAN |
Protein Name | ATP-dependent DNA helicase Q4 |
Gene Name | Name: RECQL4 Synonyms:RECQ4; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O94761 |
PRO Name | ATP-dependent DNA helicase Q4 (human) |
Definition | An ATP-dependent DNA helicase Q4 that is encoded in the genome of human. |
Short Label | hRECQL4 |
Category | organism-gene |
O94761 (RECQL4) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S27 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S89 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29229926 | ||
T93 | O-Glycosylation | score1 | GlyGen | 30379171, 34019948 | ||
T93 | Phosphorylation | score1 | PhosphoSitePlus | |||
S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
K110 | Methylation | score1 | PhosphoSitePlus | |||
K114 | Methylation | score1 | PhosphoSitePlus | |||
T139 | Phosphorylation | score1 | PhosphoSitePlus | |||
S178 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S180 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
S251 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29229926 | ||
K261 | Ubiquitination | score1 | PhosphoSitePlus | |||
S323 | Phosphorylation | score1 | PhosphoSitePlus | |||
K332 | Sumoylation | score1 | PhosphoSitePlus | |||
K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y353 | Phosphorylation | score1 | PhosphoSitePlus | |||
K376 | Acetylation | score1 | PhosphoSitePlus | |||
K380 | Acetylation | score1 | PhosphoSitePlus | |||
K382 | Acetylation | score1 | PhosphoSitePlus | |||
K385 | Acetylation | score1 | PhosphoSitePlus | |||
K386 | Acetylation | score1 | PhosphoSitePlus | |||
K386 | Ubiquitination | score1 | PhosphoSitePlus | |||
K695 | Ubiquitination | score1 | PhosphoSitePlus | |||
S732 | Phosphorylation | score1 | PhosphoSitePlus | |||
K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
T771 | Phosphorylation | score1 | PhosphoSitePlus | |||
K843 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1048 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1101 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1154 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O94761 (RECQL4) | S251 | P49959 (MRE11) | increased_association | eFIP | 29229926 | |
Phosphorylation | O94761 (RECQL4) | S251 | Q16531 (DDB1) | increased_association | eFIP | 29229926 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S101 | L101 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S251 | I251 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S251 | R251 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S323 | N323 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K332 | N332 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K385 | M385 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
T771 | M771 | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
K1048 | N1048 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K1048 | E1048 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |