iPTMnet Report for O94761 (RECQL4)
Protein Information
| UniProt AC / UniProt ID | O94761 / RECQ4_HUMAN |
| Protein Name | ATP-dependent DNA helicase Q4 |
| Gene Name | Name: RECQL4 Synonyms:RECQ4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O94761 |
| PRO Name | ATP-dependent DNA helicase Q4 (human) |
| Definition | An ATP-dependent DNA helicase Q4 that is encoded in the genome of human. |
| Short Label | hRECQL4 |
| Category | organism-gene |
DAG ViewO94761 (RECQL4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S27 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S89 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29229926 | ||
| T93 | O-Glycosylation | score1 | GlyGen | 30379171, 34019948 | ||
| T93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K110 | Methylation | score1 | PhosphoSitePlus | |||
| K114 | Methylation | score1 | PhosphoSitePlus | |||
| T139 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S178 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S180 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S251 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29229926 | ||
| K261 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S323 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K332 | Sumoylation | score1 | PhosphoSitePlus | |||
| K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K376 | Acetylation | score1 | PhosphoSitePlus | |||
| K380 | Acetylation | score1 | PhosphoSitePlus | |||
| K382 | Acetylation | score1 | PhosphoSitePlus | |||
| K385 | Acetylation | score1 | PhosphoSitePlus | |||
| K386 | Acetylation | score1 | PhosphoSitePlus | |||
| K386 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K695 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S732 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T771 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K843 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1048 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1101 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1154 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O94761 (RECQL4) | S251 | P49959 (MRE11) | increased_association | eFIP | 29229926 | |
| Phosphorylation | O94761 (RECQL4) | S251 | Q16531 (DDB1) | increased_association | eFIP | 29229926 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S101 | L101 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S251 | I251 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S251 | R251 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S323 | N323 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K332 | N332 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K385 | M385 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| T771 | M771 | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| K1048 | N1048 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K1048 | E1048 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
