iPTMnet Report for O76031 (CLPX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76031 / CLPX_HUMAN
Protein Name ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
Gene Name Name: CLPX
Organism Homo sapiens (Human)

PRO ID PR:O76031
DAG View
PRO Name ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (human)
Definition An ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial that is encoded in the genome of human.
Short Label hCLPX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76031 (CLPX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
S152 O-Glycosylation GlyGen 30379171, 28510447, 33465208
K178 Acetylation PhosphoSitePlus
K187 Methylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
R270 Methylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
R373 Methylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K437 Acetylation PhosphoSitePlus   UniProt 19608861
K437 Ubiquitination PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S463 O-Glycosylation GlyGen 30379171, 28510447, 33465208
K475 Acetylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K591 Acetylation PhosphoSitePlus
K597 Acetylation PhosphoSitePlus
T607 Phosphorylation PhosphoSitePlus
S610 Phosphorylation HPRD   PhosphoSitePlus 18452278
S611 Phosphorylation PhosphoSitePlus
S617 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19690332, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 F29 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S36 P36 Biomuta DOID:1319 / brain cancer [ cosmic ]
K98 E98 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S220 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K349 T349 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K362 R362 Biomuta DOID:4159 / skin cancer [ cosmic ]
S420 C420 Biomuta DOID:4159 / skin cancer [ cosmic ]
S611 F611 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S617 F617 Biomuta DOID:4159 / skin cancer [ cosmic ]