iPTMnet Report for O75943 (RAD17)
Protein Information
| UniProt AC / UniProt ID | O75943 / RAD17_HUMAN |
| Protein Name | Cell cycle checkpoint protein RAD17 |
| Gene Name | Name: RAD17 Synonyms:R24L; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O75943 |
| PRO Name | cell cycle checkpoint protein RAD17 (human) |
| Definition | A cell cycle checkpoint protein RAD17 that is encoded in the genome of human. |
| Short Label | hRAD17 |
| Category | organism-gene |
DAG ViewO75943 (RAD17) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| T4 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| T55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R66 | Methylation | score1 | PhosphoSitePlus | |||
| S71 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S81 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S86 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K118 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K152 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K171 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K319 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S359 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S362 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S410 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S416 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K597 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T633 | Phosphorylation | score3 | IntAct PhosphoSitePlus | 24534091 | ||
| S646 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 10608806, 14871926, 11687627, ... | ||
| S646 | Phosphorylation | Q13315 (ATM) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 10608806, 11418864 | |
| S646 | Phosphorylation | Q13535 (ATR) | score4 | neXtProt PhosphoSitePlus Signor | 10608806, 11418864, 11687627 | |
| S656 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 10608806, 21777809, 11687627, ... | ||
| S656 | Phosphorylation | Q13315 (ATM) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 10608806, 11418864 | |
| S656 | Phosphorylation | Q13535 (ATR) | score4 | neXtProt PhosphoSitePlus Signor | 10608806, 11418864, 11687627, ... | |
| Y676 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S678 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T681 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T304 | Phosphorylation | score0 | HPRD | 17924679 | ||
| S646 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S646 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S646 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 | |
| S656 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S656 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S656 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T293 | Phosphorylation | score0 | HPRD | 17924679 | ||
| S635 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S635 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S635 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 | |
| S645 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S645 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S645 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T128 | Phosphorylation | score0 | HPRD | 17924679 | ||
| S470 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S470 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S470 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 | |
| S480 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S480 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S480 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T207 | Phosphorylation | score0 | HPRD | 17924679 | ||
| S549 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S549 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S549 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 | |
| S559 | Phosphorylation | score2 | HPRD | 10608806, 11418864 | ||
| S559 | Phosphorylation | Q13315 (ATM) | score2 | HPRD | 10608806, 11418864 | |
| S559 | Phosphorylation | Q13535 (ATR) | score2 | HPRD | 10608806, 11418864 |
O75943 (RAD17) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | P2 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S81 | * | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S81 | L81 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K107 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S678 | R678 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| T681 | A681 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
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