Protein Information

Cytoscape View


UniProt AC / UniProt ID O75943 / RAD17_HUMAN
Protein Name Cell cycle checkpoint protein RAD17
Gene Name Name: RAD17
Synonyms:R24L;
Organism Homo sapiens (Human)

PRO ID PR:O75943
DAG View
PRO Name cell cycle checkpoint protein RAD17 (human)
Definition A cell cycle checkpoint protein RAD17 that is encoded in the genome of human.
Short Label hRAD17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75943 (RAD17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T55 Phosphorylation PhosphoSitePlus
R66 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   UniProt 23186163
S81 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
K107 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163
S362 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
T633 Phosphorylation IntAct   PhosphoSitePlus 24534091
S646 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10608806, 14871926, 11687627, ...14500819, 11418864
S656 Phosphorylation Q13315 (ATM) , Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10608806, 21777809, 11687627, ...14500819, 11418864
Y676 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T304 Phosphorylation HPRD 17924679
S646 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
S656 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
Site PTM Type PTM Enzyme Score Source PMID
T293 Phosphorylation HPRD 17924679
S635 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
S645 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
Site PTM Type PTM Enzyme Score Source PMID
T128 Phosphorylation HPRD 17924679
S470 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
S480 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
Site PTM Type PTM Enzyme Score Source PMID
T207 Phosphorylation HPRD 17924679
S549 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD 10608806, 11418864
S559 Phosphorylation Q13535 (ATR) , Q13315 (ATM) HPRD 10608806, 11418864


O75943 (RAD17) as PTM Enzyme



Substrate Site Score Source PMID
Q13535-1 (ATR) S480 HPRD 10608806, 11418864
Q13535-1 (ATR) S549 HPRD 10608806, 11418864


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75943 (RAD17) T633 O60934 (NBN) unknown eFIP 24534091


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S81 L81 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S678 R678 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T681 A681 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]