iPTMnet Report for O75914 (PAK3)
Protein Information
| UniProt AC / UniProt ID | O75914 / PAK3_HUMAN |
| Protein Name | Serine/threonine-protein kinase PAK 3 |
| Gene Name | Name: PAK3 Synonyms:OPHN3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O75914 |
| PRO Name | serine/threonine-protein kinase PAK 3 (human) |
| Definition | A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human. |
| Short Label | hPAK3 |
| Category | organism-gene |
DAG ViewO75914 (PAK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N22 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| S50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K58 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K62 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N121 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S154 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| S186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T218 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S220 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K257 | Acetylation | score1 | PhosphoSitePlus | |||
| S259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K269 | Acetylation | score1 | PhosphoSitePlus | |||
| S272 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S275 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y298 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K322 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K404 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T428 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K433 | Acetylation | score1 | PhosphoSitePlus | |||
| K433 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S435 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T436 | Phosphorylation | score3 | PRO PhosphoSitePlus RLIMS-P | 30858169 | ||
| T440 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y477 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S524 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K526 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K535 | Acetylation | score1 | PhosphoSitePlus | |||
| K535 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S558 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S139 | Phosphorylation | O75914 (PAK3) | score4 | HPRD phospho.ELM | 16204230, 11278486 | |
| T421 | Phosphorylation | O75914 (PAK3) | score4 | HPRD phospho.ELM | 16204230, 11278486 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T140 | Phosphorylation | score1 | PhosphoSitePlus |
O75914 (PAK3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O75914-2 (PAK3) | S139 | score4 | HPRD phospho.ELM | 16204230, 11278486 | |
| O75914-2 (PAK3) | T421 | score4 | HPRD phospho.ELM | 16204230, 11278486 | |
| P04049 (RAF1) | S338 | score4 | HPRD neXtProt phospho.ELM Signor | 11733498, 9234708, 10205168, ... | |
| P04049 (RAF1) | S339 | score2 | neXtProt | 9823899 | |
| P17600-1 (SYN1) | S605 | score1 | HPRD | 12237306 | |
| P19429 (TNNI3) | S150 | score4 | phospho.ELM Signor | 12242269, 15769444 | |
| Q02750 (MAP2K1) | S298 | score2 | neXtProt | 12876277 | |
| Q05682 (CALD1) | S714 | score1 | Signor | 20858431 | |
| Q05682 (CALD1) | S744 | score1 | Signor | 20858431 | |
| Q16659 (MAPK6) | S189 | score2 | neXtProt | 21177870 | |
| Q9UM54-1 (MYO6) | T405 | score2 | HPRD | 20068231, 11517222 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048693 (hPAK3/Phos:1) | pS154,pT436 | PRO |
PTM sites affected in variants
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