Protein Information

Cytoscape View


UniProt AC / UniProt ID O75648 / MTU1_HUMAN
Protein Name Mitochondrial tRNA-specific 2-thiouridylase 1
Gene Name Name: TRMU
Synonyms:MTU1,TRMT1;
Organism Homo sapiens (Human)

PRO ID PR:O75648
DAG View
PRO Name mitochondrial tRNA-specific 2-thiouridylase 1 (human)
Definition A mitochondrial tRNA-specific 2-thiouridylase 1 that is encoded in the genome of human.
Short Label hTRMU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75648 (TRMU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
R332 Methylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K142 M142 Biomuta DOID:363 / uterine cancer [ tcga ]
R332 P332 Biomuta DOID:11934 / head and neck cancer [ tcga ]