iPTMnet Report O75582 RPS6KA5

Protein Information

UniProt AC / UniProt ID	O75582 / KS6A5_HUMAN
Protein Name	Ribosomal protein S6 kinase alpha-5
Gene Name	Name: RPS6KA5 Synonyms:MSK1;
Organism	Homo sapiens (Human)

PRO ID	PR:O75582 DAG View
PRO Name	ribosomal protein S6 kinase alpha-5 (human)
Definition	A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.
Short Label	hRPS6KA5
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O75582 (RPS6KA5) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T38	Phosphorylation		score1	PhosphoSitePlus
K53	Ubiquitination		score1	PhosphoSitePlus
Y60	Phosphorylation		score1	PhosphoSitePlus
Y175	Phosphorylation		score1	PhosphoSitePlus
S187	O-Glycosylation		score1	GlyGen	23301498, 29351928
S199	Phosphorylation		score1	PhosphoSitePlus
S212	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	30305627, 15568999, 33563994
S212	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
S240	Phosphorylation		score1	PhosphoSitePlus
S253	Phosphorylation		score1	PhosphoSitePlus
S268	Phosphorylation		score1	PhosphoSitePlus
K273	Ubiquitination		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
K329	Ubiquitination		score1	PhosphoSitePlus
S360	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	15568999, 17117922, 11940578, ...15635602, 9687510, 26305102, 30305627
S360	Phosphorylation	P27361 (MAPK3)	score3	phospho.ELM PhosphoSitePlus Signor	15568999
S360	Phosphorylation	P28482 (MAPK1)	score4	phospho.ELM PhosphoSitePlus Signor	11940578, 15568999, 9687510
S360	Phosphorylation	Q15759 (MAPK11)	score1	Signor	9687510
S360	Phosphorylation	Q16539 (MAPK14)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	17117922, 15568999
Y375	Phosphorylation		score1	PhosphoSitePlus
S376	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	16543895, 26030901, 15568999, ...27385346, 24027420, 15302935, 15635602, 26305102, 33563994, 19690332, 20068231, 15684425
S376	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
S381	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15568999, 20068231
S381	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
K385	Ubiquitination		score1	PhosphoSitePlus
S436	Phosphorylation		score1	PhosphoSitePlus
S448	Phosphorylation		score1	PhosphoSitePlus
K473	Ubiquitination		score1	PhosphoSitePlus
K527	Ubiquitination		score1	PhosphoSitePlus
K546	Ubiquitination		score1	PhosphoSitePlus
T581	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	16543895, 15568999, 27385346, ...22312446, 17117922, 26030901, 11940578, 15635602, 18267068, 9687510, 26305102, 30305627, 25958199, 17429437
T581	Phosphorylation	P27361 (MAPK3)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	17117922, 15568999
T581	Phosphorylation	P28482 (MAPK1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	11940578, 17117922, 18267068, ...15568999
T581	Phosphorylation	Q15759 (MAPK11)	score1	Signor	9687510
T581	Phosphorylation	Q16539 (MAPK14)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	17117922, 15568999, 17429437
S628	Phosphorylation		score1	PhosphoSitePlus
T630	Phosphorylation		score0	RLIMS-P	17117922
S647	Phosphorylation		score3	RLIMS-P UniProt	17117922
K654	Ubiquitination		score1	PhosphoSitePlus
S657	Phosphorylation		score3	RLIMS-P UniProt	17117922
K661	Ubiquitination		score1	PhosphoSitePlus
K674	Ubiquitination		score1	PhosphoSitePlus
K677	Ubiquitination		score1	PhosphoSitePlus
Y683	Phosphorylation		score1	PhosphoSitePlus
S691	Phosphorylation		score1	PhosphoSitePlus
S694	Phosphorylation		score1	PhosphoSitePlus
S695	Phosphorylation		score3	PhosphoSitePlus RLIMS-P UniProt	17117922
T700	Phosphorylation		score4	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	17117922, 30305627, 9687510
T700	Phosphorylation	P27361 (MAPK3)	score2	neXtProt	17117922
T700	Phosphorylation	P28482 (MAPK1)	score2	neXtProt	17117922
T700	Phosphorylation	Q15759 (MAPK11)	score1	Signor	9687510
T700	Phosphorylation	Q16539 (MAPK14)	score2	neXtProt	17117922
S750	Phosphorylation		score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15568999
S750	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
T751	Phosphorylation		score1	PhosphoSitePlus
S752	Phosphorylation		score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15568999
S752	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
S757	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20044958
S757	Phosphorylation	P68400 (CSNK2A1)	score2	PhosphoSitePlus	20044958
S758	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	20044958, 15568999
S758	Phosphorylation	O75582 (RPS6KA5)	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
S758	Phosphorylation	P68400 (CSNK2A1)	score2	PhosphoSitePlus	20044958
S759	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20044958
S759	Phosphorylation	P68400 (CSNK2A1)	score2	PhosphoSitePlus	20044958
S760	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20044958
S760	Phosphorylation	P68400 (CSNK2A1)	score2	PhosphoSitePlus	20044958
S766	Phosphorylation		score1	PhosphoSitePlus
S770	Phosphorylation		score1	PhosphoSitePlus
T793	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20044958
T793	Phosphorylation	P68400 (CSNK2A1)	score2	PhosphoSitePlus	20044958

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S376	Phosphorylation		score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	P27361 (MAPK3)	score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	P28482 (MAPK1)	score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	19651622, 11994045, 20068231
S381	Phosphorylation		score0	HPRD	19651622, 20068231
T581	Phosphorylation		score2	HPRD	11994045, 14578350
T581	Phosphorylation	P27361 (MAPK3)	score1	HPRD	11994045
T581	Phosphorylation	P28482 (MAPK1)	score1	HPRD	11994045
T581	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	11994045, 14578350

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S376	Phosphorylation		score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	P27361 (MAPK3)	score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	P28482 (MAPK1)	score2	HPRD	19651622, 11994045, 20068231
S376	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	19651622, 11994045, 20068231
S381	Phosphorylation		score0	HPRD	19651622, 20068231

O75582 (RPS6KA5) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O75582 (RPS6KA5)	S212	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
O75582 (RPS6KA5)	S376	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
O75582 (RPS6KA5)	S381	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
O75582 (RPS6KA5)	S750	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
O75582 (RPS6KA5)	S752	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
O75582 (RPS6KA5)	S758	score3	neXtProt PhosphoSitePlus Signor UniProt	15568999
P05114 (HMGN1)	S7	score4	HPRD neXtProt	20166139, 12773393, 11438671, ...20089855, 17924679
P07101-3 (TH)	S40	score3	HPRD PhosphoSitePlus Signor	12421349
P0C0S8 (H2AC17)	S2	score0	Signor	15010469
P10276 (RARA)	S369	score3	neXtProt PhosphoSitePlus	19078967
P10636-5 (MAPT)	S214	score2	neXtProt	17512525
P10636-5 (MAPT)	S262	score2	neXtProt	17512525
P11831 (SRF)	S103	score2	PhosphoSitePlus	20089855
P16220 (CREB1)	S119	score1	Signor	9687510
P16220-1 (CREB1)	S133	score2	HPRD	11018520, 11909979, 9687510
P18846-1 (ATF1)	S63	score4	HPRD neXtProt PhosphoSitePlus Signor	12414794, 18690222, 8663317, ...11909979, 20089855, 20068231
P19419 (ELK1)	S383	score4	PhosphoSitePlus Signor	11145955, 20089855
P22736-1 (NR4A1)	S351	score3	HPRD Signor	11274386, 16223362, 18669648
P40763-2 (STAT3)	S726	score2	HPRD	19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
P40763 (STAT3)	S727	score4	HPRD neXtProt Signor	19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
P42224-1 (STAT1)	S727	score4	HPRD neXtProt	18691976, 15322115, 20058876, ...7543024, 18452278, 11839738, 11972023, 18669648, 14963018, 7690989, 9355737, 12637327, 20068231
P47712 (PLA2G4A)	S727	score3	HPRD Signor	16964243, 19664994, 18669648, ...10978317, 20068231, 18212344
P50549-1 (ETV1)	S191	score3	HPRD neXtProt	12569367
P50549 (ETV1)	S216	score4	HPRD neXtProt Signor	12569367, 12213813
P50549-1 (ETV1)	S334	score1	HPRD	12569367
P54253 (ATXN1)	S775	score2	PhosphoSitePlus	23719381
P68431 (H3C12)	S11	score2	Signor	10464286, 14625384, 15994958
P68431 (H3C12)	S29	score1	Signor	20129940
P84243 (H3-3B)	S11	score2	Signor	10464286, 14625384, 18508628, ...15994958
P84243 (H3-3B)	S29	score1	Signor	18508628
Q04206 (RELA)	S276	score4	neXtProt PhosphoSitePlus Signor	19197368, 19706715, 23536830, ...12628924
Q13541 (EIF4EBP1)	T36	score4	HPRD neXtProt	11777913, 18669648, 20068231
Q13541 (EIF4EBP1)	T45	score4	HPRD neXtProt	11777913, 19413330, 18669648, ...20068231
Q13541 (EIF4EBP1)	S65	score4	HPRD neXtProt	11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
Q15831 (STK11)	S428	score3	HPRD neXtProt	11297520
Q16695 (H3-4)	S11	score2	HPRD	10469656, 12773393
Q16695 (H3-4)	S29	score2	HPRD	12773393, 20068231, 18691976
Q7L7L0 (H2AC25)	S2	score0	HPRD	15010469
Q92934 (BAD)	S75	score3	neXtProt	11983683, 17663748
Q92934 (BAD)	S153	score1	HPRD	10880354
Q9H4A3 (WNK1)	T60	score2	PhosphoSitePlus	14611643

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049132 (hRPS6KA5/Phos:2)	pS212,pS360,pS376,pT581		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K53	N53	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S187	F187	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S212	Y212	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S212	F212	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S240	N240	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
S253	Y253	Biomuta	DOID:1319 / brain cancer [ cosmic ]
Y375	F375	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S376	C376	Biomuta	DOID:11054 / urinary bladder cancer [ icgc ]
T630	M630	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S647	F647	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K654	N654	Biomuta	DOID:363 / uterine cancer [ cosmic ]
K677	N677	Biomuta	DOID:4362 / cervical cancer [ cosmic ]
Y683	H683	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S750	I750	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T751	S751	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S758	N758	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S766	P766	Biomuta	DOID:363 / uterine cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O75582 (RPS6KA5)

Protein Information

Interactive Sequence View

O75582 (RPS6KA5) as Substrate

O75582 (RPS6KA5) as PTM Enzyme

Proteoforms

PTM sites affected in variants