Protein Information

Cytoscape View


UniProt AC / UniProt ID O75582 / KS6A5_HUMAN
Protein Name Ribosomal protein S6 kinase alpha-5
Gene Name Name: RPS6KA5
Synonyms:MSK1;
Organism Homo sapiens (Human)

PRO ID PR:O75582
DAG View
PRO Name ribosomal protein S6 kinase alpha-5 (human)
Definition A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.
Short Label hRPS6KA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75582 (RPS6KA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T38 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
S187 O-Glycosylation GlyGen 23301498, 29351928
S199 Phosphorylation PhosphoSitePlus
S212 Phosphorylation O75582 (RPS6KA5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30305627, 15568999, 33563994
S240 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S360 Phosphorylation P27361 (MAPK3) , Q16539 (MAPK14) , Q15759 (MAPK11) , P28482 (MAPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15568999, 17117922, 11940578, ...15635602, 9687510, 26305102, 30305627
Y375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation O75582 (RPS6KA5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16543895, 26030901, 15568999, ...27385346, 24027420, 15302935, 15635602, 26305102, 33563994, 19690332, 20068231, 15684425
S381 Phosphorylation O75582 (RPS6KA5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15568999, 20068231
K385 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
T581 Phosphorylation Q15759 (MAPK11) , P28482 (MAPK1) , Q16539 (MAPK14) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16543895, 15568999, 27385346, ...22312446, 17117922, 26030901, 11940578, 15635602, 18267068, 9687510, 26305102, 30305627, 25958199, 17429437
S628 Phosphorylation PhosphoSitePlus
T630 Phosphorylation RLIMS-P 17117922
S647 Phosphorylation RLIMS-P   UniProt 17117922
K654 Ubiquitination PhosphoSitePlus
S657 Phosphorylation RLIMS-P   UniProt 17117922
K661 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17117922
T700 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) , P27361 (MAPK3) , Q15759 (MAPK11) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17117922, 30305627, 9687510
S750 Phosphorylation O75582 (RPS6KA5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15568999
T751 Phosphorylation PhosphoSitePlus
S752 Phosphorylation O75582 (RPS6KA5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15568999
S757 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 20044958
S758 Phosphorylation O75582 (RPS6KA5) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20044958, 15568999
S759 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 20044958
S760 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 20044958
S766 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
T793 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 20044958
Site PTM Type PTM Enzyme Score Source PMID
S376 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) , P27361 (MAPK3) HPRD 19651622, 11994045, 20068231
S381 Phosphorylation HPRD 19651622, 20068231
T581 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , Q16539 (MAPK14) HPRD 11994045, 14578350
Site PTM Type PTM Enzyme Score Source PMID
S376 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) , P27361 (MAPK3) HPRD 19651622, 11994045, 20068231
S381 Phosphorylation HPRD 19651622, 20068231


O75582 (RPS6KA5) as PTM Enzyme



Substrate Site Score Source PMID
O75582 (RPS6KA5) S212 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
O75582 (RPS6KA5) S376 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
O75582 (RPS6KA5) S381 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
O75582 (RPS6KA5) S750 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
O75582 (RPS6KA5) S752 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
O75582 (RPS6KA5) S758 neXtProt   PhosphoSitePlus   Signor   UniProt 15568999
P05114 (HMGN1) S7 HPRD   neXtProt 20166139, 12773393, 11438671, ...17924679, 20089855
P07101-3 (TH) S40 HPRD   PhosphoSitePlus   Signor 12421349
P0C0S8 (H2AC17) S2 Signor 15010469
P10276 (RARA) S369 neXtProt   PhosphoSitePlus 19078967
P10636-5 (MAPT) S214 neXtProt 17512525
P10636-5 (MAPT) S262 neXtProt 17512525
P11831 (SRF) S103 PhosphoSitePlus 20089855
P16220 (CREB1) S119 Signor 9687510
P16220-1 (CREB1) S133 HPRD 11018520, 11909979, 9687510
P18846 (ATF1) S63 HPRD   neXtProt   PhosphoSitePlus   Signor 12414794, 18690222, 8663317, ...11909979, 20089855, 20068231
P19419 (ELK1) S383 PhosphoSitePlus   Signor 11145955, 20089855
P22736 (NR4A1) S351 HPRD   Signor 11274386, 16223362, 18669648
P40763-2 (STAT3) S726 HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
P40763 (STAT3) S727 HPRD   neXtProt   Signor 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
P42224 (STAT1) S727 HPRD   neXtProt 18691976, 15322115, 20058876, ...7543024, 18452278, 11839738, 11972023, 18669648, 14963018, 7690989, 9355737, 12637327, 20068231
P47712 (PLA2G4A) S727 HPRD   Signor 16964243, 19664994, 18669648, ...10978317, 20068231, 18212344
P50549-1 (ETV1) S191 HPRD   neXtProt 12569367
P50549 (ETV1) S216 HPRD   neXtProt   Signor 12569367, 12213813
P50549-1 (ETV1) S334 HPRD 12569367
P54253 (ATXN1) S775 PhosphoSitePlus 23719381
P68431 (H3C12) S11 Signor 10464286, 14625384, 15994958
P68431 (H3C12) S29 Signor 20129940
P84243 (H3-3B) S11 Signor 10464286, 14625384, 18508628, ...15994958
P84243 (H3-3B) S29 Signor 18508628
Q04206 (RELA) S276 neXtProt   PhosphoSitePlus   Signor 19197368, 19706715, 23536830, ...12628924
Q13541 (EIF4EBP1) T36 HPRD   neXtProt 11777913, 18669648, 20068231
Q13541 (EIF4EBP1) T45 HPRD   neXtProt 11777913, 19413330, 18669648, ...20068231
Q13541 (EIF4EBP1) S65 HPRD   neXtProt 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
Q15831 (STK11) S428 HPRD   neXtProt 11297520
Q16695 (H3-4) S11 HPRD 10469656, 12773393
Q16695 (H3-4) S29 HPRD 12773393, 20068231, 18691976
Q7L7L0 (H2AW) S2 HPRD 15010469
Q92934 (BAD) S75 neXtProt 11983683, 17663748
Q92934 (BAD) S153 HPRD 10880354
Q9H4A3 (WNK1) T60 PhosphoSitePlus 14611643


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049132 (hRPS6KA5/Phos:2) pS212,pS360,pS376,pT581 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K53 N53 Biomuta DOID:1324 / lung cancer [ tcga ]
S187 F187 Biomuta DOID:1612 / breast cancer [ tcga ]
S240 N240 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S253 Y253 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y375 F375 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S376 C376 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S436 R436 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
K654 N654 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K677 N677 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
Y683 H683 Biomuta DOID:1909 / melanoma [ cosmic ]
S750 I750 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S750 R750 Biomuta DOID:3571 / liver cancer [ icgc ]
T751 S751 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S766 P766 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]