iPTMnet Report for O75531 (BANF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75531 / BAF_HUMAN
Protein Name Barrier-to-autointegration factor
Gene Name Name: BANF1
Synonyms:BAF;
Organism Homo sapiens (Human)

PRO ID PR:O75531
DAG View
PRO Name barrier-to-autointegration factor (human)
Definition A barrier-to-autointegration factor that is encoded in the genome of human.
Short Label hBANF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75531 (BANF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 20068231
T2 Acetylation UniProt 19413330
T2 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 24945635, 24265311, ...16495336, 20068231
T2 Phosphorylation Q86Y07 (VRK2) PhosphoSitePlus   Signor 16495336
T2 Phosphorylation Q99986 (VRK1) PhosphoSitePlus   Signor 16495336
T3 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 24945635, 24265311, ...16495336, 20068231, 33744941
T3 Phosphorylation Q86Y07 (VRK2) PhosphoSitePlus   Signor 16495336
T3 Phosphorylation Q99986 (VRK1) PhosphoSitePlus   Signor 16495336
S4 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 20511217, 31164634, ...16371512, 34909681, 24265311, 25899223, 24945635, 16495336, 24430874, 20068231, 33744941
S4 Phosphorylation Q86Y07 (VRK2) neXtProt   PhosphoSitePlus   Signor 16371512, 16495336, 20511217
S4 Phosphorylation Q8IV63 (VRK3) PhosphoSitePlus 25899223
S4 Phosphorylation Q99986 (VRK1) PhosphoSitePlus   Signor 16371512, 16495336
K6 Acetylation PhosphoSitePlus
K6 Sumoylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S22 Phosphorylation HPRD   PhosphoSitePlus 20068231
K32 Ubiquitination PhosphoSitePlus
R37 Methylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
R60 Methylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
R82 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036220 (hBANF1/Ac:1) acM1 PRO
PR:000046460 (hBANF1/Phos:2) pT2,pT3,pS4 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75531 (BANF1) S4 P50402 (EMD) unknown eFIP 16371512
Phosphorylation Q9Y2U8 (LEMD3) S402 O75531 (BANF1) unknown eFIP 19166343


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S22 N22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K32 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R60 Q60 Biomuta DOID:1612 / breast cancer [ cosmic ]
R82 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]