Protein Information

Cytoscape View

UniProt AC / UniProt ID O75531 / BAF_HUMAN
Protein Name Barrier-to-autointegration factor
Gene Name Name: BANF1
Organism Homo sapiens (Human)

PRO ID PR:O75531
DAG View
PRO Name barrier-to-autointegration factor (human)
Definition A barrier-to-autointegration factor that is encoded in the genome of human.
Short Label hBANF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O75531 (BANF1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 20068231
T2 Acetylation UniProt 19413330
T2 Phosphorylation Q99986 (VRK1) , Q86Y07 (VRK2) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 24945635, 24265311, ...16495336, 20068231
T3 Phosphorylation Q86Y07 (VRK2) , Q99986 (VRK1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 24945635, 24265311, ...16495336, 20068231, 33744941
S4 Phosphorylation Q86Y07 (VRK2) , Q99986 (VRK1) , Q8IV63 (VRK3) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 20511217, 31164634, ...16371512, 24265311, 25899223, 24945635, 16495336, 24430874, 20068231, 33744941
K6 Acetylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S22 Phosphorylation HPRD   PhosphoSitePlus 20068231
K32 Ubiquitination PhosphoSitePlus
R37 Methylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
R60 Methylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
R82 Methylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036220 (hBANF1/Ac:1) acM1 PRO
PR:000046460 (hBANF1/Phos:2) pT2,pT3,pS4 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75531 (BANF1) S4 P50402 (EMD) unknown eFIP 16371512
Phosphorylation Q9Y2U8 (LEMD3) S402 O75531 (BANF1) unknown eFIP 19166343

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:1612 / breast cancer [ tcga ]
K18 N18 Biomuta DOID:3571 / liver cancer [ icgc ]
S22 N22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K32 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
R60 Q60 Biomuta DOID:1612 / breast cancer [ cosmic ]
R82 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3070 / malignant glioma [ tcga ]