iPTMnet Report for O75096 (LRP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75096 / LRP4_HUMAN
Protein Name Low-density lipoprotein receptor-related protein 4 precursor
Gene Name Name: LRP4
Synonyms:KIAA0816,LRP10,MEGF7;
Organism Homo sapiens (Human)

PRO ID PR:O75096
DAG View
PRO Name low-density lipoprotein receptor-related protein 4 (human)
Definition A low-density lipoprotein receptor-related protein 4 that is encoded in the genome of human.
Short Label hLRP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75096 (LRP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T70 O-Glycosylation GlyGen 30459171
S184 O-Glycosylation GlyGen 30459171
T604 O-Glycosylation GlyGen 29351928
T689 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
Y918 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
T975 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
T1126 Phosphorylation PhosphoSitePlus
N1415 N-Glycosylation GlyGen 24190977
N1418 N-Glycosylation GlyGen 24190977
N1467 N-Glycosylation GlyGen 24190977
N1468 N-Glycosylation GlyGen 24190977
Y1484 Phosphorylation PhosphoSitePlus
T1512 Phosphorylation PhosphoSitePlus
T1688 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S1689 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K1753 Ubiquitination PhosphoSitePlus
Y1764 Phosphorylation PhosphoSitePlus
K1777 Ubiquitination PhosphoSitePlus
Y1787 Phosphorylation PhosphoSitePlus
Y1792 Phosphorylation PhosphoSitePlus
R1833 Methylation PhosphoSitePlus
S1887 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T689 I689 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1126 S1126 Biomuta DOID:1324 / lung cancer [ cosmic ]
N1468 Y1468 Biomuta DOID:263 / kidney cancer [ cosmic ]
T1512 I1512 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1688 M1688 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1753 R1753 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1833 W1833 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]