iPTMnet Report for O60825 (PFKFB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60825 / F262_HUMAN
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Gene Name Name: PFKFB2
Organism Homo sapiens (Human)

PRO ID PR:O60825
DAG View
PRO Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (human)
Definition A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human.
Short Label hPFKFB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60825 (PFKFB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
S13 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
C397 Methylation IEDB 31844290
T458 Phosphorylation PhosphoSitePlus
S466 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 11069105, 23186163, ...18220336, 10521487, 20958264, 18669648, 36402789, 12853467, 2846551, 20068231, 9211863
S466 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 12853467
S466 Phosphorylation P23443 (RPS6KB1) Signor 2846551, 9211863
S466 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12853467, 10521487
S466 Phosphorylation P51812 (RPS6KA3) Signor 2846551, 9211863
S466 Phosphorylation P54646 (PRKAA2) neXtProt   Signor 11069105
S466 Phosphorylation Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   Signor 12853467, 11069105
T468 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 36402789, 18220336
S471 O-Glycosylation GlyGen 31373491
S471 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S472 O-Glycosylation GlyGen 31373491
S472 Phosphorylation PhosphoSitePlus
T475 O-Glycosylation GlyGen 31373491
T475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30819197, 23457334, 29221144, ...12853467, 18669648, 36402789, 20958264, 20068231
S483 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12853467, 23457334
S486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 36402789
S493 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...36402789
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 20068231
S32 Phosphorylation HPRD 20068231
S466 Phosphorylation HPRD 19413330, 18767875, 19651622, ...18669648, 12853467, 20068231, 17924679
S466 Phosphorylation P17612 (PRKACA) HPRD 19413330, 18767875, 19651622, ...18669648, 12853467, 20068231, 17924679
S466 Phosphorylation P31749 (AKT1) HPRD 19413330, 18767875, 19651622, ...18669648, 12853467, 20068231, 17924679
S466 Phosphorylation P54646 (PRKAA2) HPRD 19413330, 18767875, 19651622, ...18669648, 12853467, 20068231, 17924679
S466 Phosphorylation Q13131 (PRKAA1) HPRD 19413330, 18767875, 19651622, ...18669648, 12853467, 20068231, 17924679
T468 Phosphorylation HPRD 18767875, 18669648, 20068231
S471 Phosphorylation HPRD 18669648
T475 Phosphorylation HPRD 18669648, 1322130
T475 Phosphorylation P17252 (PRKCA) HPRD 18669648, 1322130
S483 Phosphorylation HPRD 12853467, 19651622, 18669648, ...20068231
S483 Phosphorylation P31749 (AKT1) HPRD 12853467, 19651622, 18669648, ...20068231
S486 Phosphorylation HPRD 18669648
S493 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 20068231
S32 Phosphorylation HPRD 20068231
S463 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S32 C32 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S84 Y84 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
K192 N192 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K287 T287 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y356 H356 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y366 H366 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y366 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C397 R397 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T458 P458 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S493 N493 Biomuta DOID:1324 / lung cancer [ cosmic ]