iPTMnet Report for O60814 (H2BC12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60814 / H2B1K_HUMAN
Protein Name Histone H2B type 1-K
Gene Name Name: H2BC12
Synonyms:H2BFT;
Organism Homo sapiens (Human)

PRO ID PR:O60814
DAG View
PRO Name histone H2B type 1-K (human)
Definition A histone H2B type 1-K that is encoded in the genome of human.
Short Label hH2BC12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60814 (H2BC12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
K6 Acetylation PRO   UniProt 18552846, 16283522, 16627869
K12 Acetylation PhosphoSitePlus   UniProt 16627869
K13 Acetylation PRO   UniProt 18552846, 16627869, 20693536, ...16283522
S15 Phosphorylation PRO   UniProt 12757711
K16 Acetylation IEDB   PRO   PhosphoSitePlus   UniProt 16283522, 19883641, 22902875, ...16627869
K17 Acetylation PRO   UniProt 20693536, 16627869
K21 Acetylation PRO   UniProt 18552846, 16283522, 16627869
K24 Acetylation PhosphoSitePlus
K35 Ubiquitination UniProt 21726816
K47 Acetylation PRO 20693536
K47 Methylation UniProt 16627869
S56 Phosphorylation PhosphoSitePlus
K58 Methylation UniProt 16627869
K109 Methylation UniProt 16627869
K121 Acetylation PRO 18552846
K121 Ubiquitination PRO   UniProt 18400894, 16307923, 16627869, ...19575011, 16713563, 18923072, 18832071


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045079 (hHIST1H2BK/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045080 (hHIST1H2BK/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045081 (hHIST1H2BK/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045083 (hHIST1H2BK/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045084 (hHIST1H2BK/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045085 (hHIST1H2BK/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045087 (hHIST1H2BK/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045088 (hHIST1H2BK/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045089 (hHIST1H2BK/InitMet-/Ac:7) acK16 PRO 19883641
PR:000047794 (hHIST1H2BK/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K13 R13 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S15 W15 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S15 L15 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K16 N16 Biomuta DOID:1324 / lung cancer [ cosmic ]
K16 E16 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K21 E21 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K24 M24 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S56 Y56 Biomuta DOID:363 / uterine cancer [ icgc ]
K121 N121 Biomuta DOID:2531 / hematologic cancer [ cosmic ]