iPTMnet Report for O60814 (H2BC12)
Protein Information
UniProt AC / UniProt ID | O60814 / H2B1K_HUMAN |
Protein Name | Histone H2B type 1-K |
Gene Name | Name: H2BC12 Synonyms:H2BFT; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O60814 |
PRO Name | histone H2B type 1-K (human) |
Definition | A histone H2B type 1-K that is encoded in the genome of human. |
Short Label | hH2BC12 |
Category | organism-gene |
O60814 (H2BC12) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Acetylation | score1 | PRO | ||||
K6 | Acetylation | score2 | PRO UniProt | 18552846, 16283522, 16627869 | ||
K12 | Acetylation | score2 | PhosphoSitePlus UniProt | 16627869 | ||
K13 | Acetylation | score2 | PRO UniProt | 18552846, 16627869, 20693536, ... | ||
S15 | Phosphorylation | score2 | PRO UniProt | 12757711 | ||
K16 | Acetylation | score4 | IEDB PRO PhosphoSitePlus UniProt | 16283522, 19883641, 22902875, ... | ||
K17 | Acetylation | score2 | PRO UniProt | 20693536, 16627869 | ||
K21 | Acetylation | score2 | PRO UniProt | 18552846, 16283522, 16627869 | ||
K24 | Acetylation | score1 | PhosphoSitePlus | |||
K35 | Ubiquitination | score1 | UniProt | 21726816 | ||
K47 | Acetylation | score1 | PRO | 20693536 | ||
K47 | Methylation | score1 | UniProt | 16627869 | ||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
K58 | Methylation | score1 | UniProt | 16627869 | ||
K109 | Methylation | score1 | UniProt | 16627869 | ||
K121 | Acetylation | score1 | PRO | 18552846 | ||
K121 | Ubiquitination | score2 | PRO UniProt | 18400894, 16307923, 16627869, ... |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000045079 (hHIST1H2BK/InitMet-/Ac:1) | acK13 | PRO | 16283522, 18552846, 20693536 | ||
PR:000045080 (hHIST1H2BK/InitMet-/Phos:1) | pS15 | PRO | 12757711 | ||
PR:000045081 (hHIST1H2BK/InitMet-/Ac:2) | acK21 | PRO | 16283522, 18552846 | ||
PR:000045083 (hHIST1H2BK/InitMet-/Ubiq:1) | ubK121 | PRO | 16307923, 16713563, 18400894, ... | ||
PR:000045084 (hHIST1H2BK/InitMet-/Ac:3) | acK17 | PRO | 20693536 | ||
PR:000045085 (hHIST1H2BK/InitMet-/Ac:4) | acK6 | PRO | 18552846 | ||
PR:000045087 (hHIST1H2BK/InitMet-/Ac:5) | acK47 | PRO | 20693536 | ||
PR:000045088 (hHIST1H2BK/InitMet-/Ac:6) | acK121 | PRO | 18552846 | ||
PR:000045089 (hHIST1H2BK/InitMet-/Ac:7) | acK16 | PRO | 19883641 | ||
PR:000047794 (hHIST1H2BK/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K12 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K13 | R13 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S15 | W15 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S15 | L15 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K16 | N16 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K16 | E16 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
K21 | E21 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K24 | M24 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S56 | Y56 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K121 | N121 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |