iPTMnet Report for O60566 (BUB1B)
Protein Information
UniProt AC / UniProt ID | O60566 / BUB1B_HUMAN |
Protein Name | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta |
Gene Name | Name: BUB1B Synonyms:BUBR1,MAD3L,SSK1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O60566 |
PRO Name | mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) |
Definition | A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. |
Short Label | hBUB1B |
Category | organism-gene |
O60566 (BUB1B) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
S39 | Phosphorylation | score1 | PhosphoSitePlus | |||
T40 | Phosphorylation | score1 | PhosphoSitePlus | |||
C51 | Methylation | score1 | IEDB | 31844290 | ||
T54 | Phosphorylation | score1 | PhosphoSitePlus | |||
K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y64 | Phosphorylation | score1 | PhosphoSitePlus | |||
S83 | Phosphorylation | score1 | PhosphoSitePlus | |||
K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
K182 | Ubiquitination | score1 | PhosphoSitePlus | |||
K210 | Ubiquitination | score1 | PhosphoSitePlus | |||
K231 | Ubiquitination | score1 | PhosphoSitePlus | |||
S232 | Phosphorylation | score1 | PhosphoSitePlus | |||
T237 | Phosphorylation | score1 | PhosphoSitePlus | |||
K250 | Acetylation | score3 | PhosphoSitePlus UniProt | 19407811 | ||
K250 | Sumoylation | score1 | PhosphoSitePlus | |||
K250 | Ubiquitination | score1 | PhosphoSitePlus | |||
K304 | Ubiquitination | score1 | PhosphoSitePlus | |||
T315 | Phosphorylation | score1 | PhosphoSitePlus | |||
S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
C356 | Methylation | score1 | IEDB | 31844290 | ||
S367 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 22067460, 23186163 | ||
T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
S384 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y404 | Phosphorylation | score1 | PhosphoSitePlus | |||
T434 | Phosphorylation | score1 | PhosphoSitePlus | |||
S435 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 22067460, 19015317, 23186163 | ||
S435 | Phosphorylation | P33981 (TTK) | score2 | PhosphoSitePlus | 19015317 | |
K438 | Ubiquitination | score1 | PhosphoSitePlus | |||
K451 | Acetylation | score1 | PhosphoSitePlus | |||
K454 | Ubiquitination | score1 | PhosphoSitePlus | |||
T471 | Phosphorylation | score1 | PhosphoSitePlus | |||
K475 | Ubiquitination | score1 | PhosphoSitePlus | |||
K479 | Ubiquitination | score1 | PhosphoSitePlus | |||
S484 | O-Glycosylation | score1 | GlyGen | 23301498, 35254053 | ||
K488 | Ubiquitination | score1 | PhosphoSitePlus | |||
S521 | Phosphorylation | score1 | PhosphoSitePlus | |||
K522 | Ubiquitination | score1 | PhosphoSitePlus | |||
S537 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22067460 | ||
K539 | Ubiquitination | score1 | PhosphoSitePlus | |||
K542 | Ubiquitination | score1 | PhosphoSitePlus | |||
S543 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 21406692, 23186163, 22067460, ... | ||
S543 | Phosphorylation | P06493 (CDK1) | score3 | neXtProt PhosphoSitePlus | 20016069 | |
S543 | Phosphorylation | P33981 (TTK) | score2 | PhosphoSitePlus | 19015317 | |
S574 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22067460 | ||
T600 | Phosphorylation | score1 | PhosphoSitePlus | |||
T608 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 22801780 | ||
T620 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 17785528 | ||
T620 | Phosphorylation | P06493 (CDK1) | score1 | Signor | 17785528 | |
K629 | Ubiquitination | score1 | PhosphoSitePlus | |||
S633 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y660 | Phosphorylation | score1 | PhosphoSitePlus | |||
S665 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K667 | Ubiquitination | score1 | PhosphoSitePlus | |||
K668 | Ubiquitination | score1 | PhosphoSitePlus | |||
S670 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18691976, 23186163, 27350047, ... | ||
S670 | Phosphorylation | P06493 (CDK1) | score3 | neXtProt PhosphoSitePlus | 20016069 | |
S670 | Phosphorylation | P33981 (TTK) | score2 | PhosphoSitePlus | 19015317 | |
S676 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 23345399, 27350047, 18824563, ... | ||
S676 | Phosphorylation | P53350 (PLK1) | score3 | phospho.ELM PhosphoSitePlus Signor | 17785528 | |
T680 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor | 30598363, 32286328, 23079597, ... | ||
T680 | Phosphorylation | P53350 (PLK1) | score3 | PhosphoSitePlus Signor | 23079597 | |
S682 | O-Glycosylation | score1 | GlyGen | 23301498, 35254053 | ||
S683 | Phosphorylation | score1 | PhosphoSitePlus | |||
S697 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K699 | Ubiquitination | score1 | PhosphoSitePlus | |||
K706 | Ubiquitination | score1 | PhosphoSitePlus | |||
T710 | Phosphorylation | score1 | PhosphoSitePlus | |||
S720 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22067460 | ||
S733 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22067460 | ||
K757 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y766 | Phosphorylation | score1 | PhosphoSitePlus | |||
K769 | Ubiquitination | score1 | PhosphoSitePlus | |||
C775 | Methylation | score1 | IEDB | 31844290 | ||
T792 | Phosphorylation | score3 | neXtProt PhosphoSitePlus Signor UniProt | 17376779 | ||
T792 | Phosphorylation | P53350 (PLK1) | score3 | neXtProt PhosphoSitePlus Signor | 17376779 | |
S797 | Phosphorylation | score1 | PhosphoSitePlus | |||
C832 | Methylation | score1 | IEDB | 31844290 | ||
C841 | Methylation | score1 | IEDB | 31844290 | ||
S884 | Phosphorylation | score1 | PhosphoSitePlus | |||
K902 | Ubiquitination | score1 | PhosphoSitePlus | |||
R919 | Methylation | score1 | PhosphoSitePlus | |||
N983 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
K988 | Ubiquitination | score1 | PhosphoSitePlus | |||
K995 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1008 | Phosphorylation | score3 | neXtProt PhosphoSitePlus Signor UniProt | 17376779 | ||
T1008 | Phosphorylation | P53350 (PLK1) | score3 | neXtProt PhosphoSitePlus Signor | 17376779 | |
K1037 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1040 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1042 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
S1043 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 22067460, 19015317, 20016069 | ||
S1043 | Phosphorylation | P06493 (CDK1) | score3 | neXtProt PhosphoSitePlus | 20016069 | |
S1043 | Phosphorylation | P33981 (TTK) | score2 | PhosphoSitePlus | 19015317 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K250 | Acetylation | score2 | PRO | 19407811 | ||
K250 | Acetylation | PR:000012332 (KAT2B) | score2 | PRO | 19407811 | |
T434 | Phosphorylation | score0 | HPRD | 20068231 | ||
S435 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S543 | Phosphorylation | score4 | HPRD PRO | 19007248, 19691289, 19651622, ... | ||
S543 | Phosphorylation | PR:000003271 (CDK1) | score3 | PRO | 19015317, 20016069 | |
T608 | Phosphorylation | score3 | PRO | 22801780, 10593653, 10749118 | ||
T620 | Phosphorylation | score2 | PRO | 17785528 | ||
T620 | Phosphorylation | PR:000003271 (CDK1) | score2 | PRO | 17785528 | |
S670 | Phosphorylation | score4 | HPRD PRO | 18691976, 19691289, 19651622, ... | ||
S670 | Phosphorylation | PR:000003271 (CDK1) | score3 | PRO | 19015317, 20016069 | |
T1042 | Phosphorylation | score0 | HPRD | 17322306, 20068231 | ||
S1043 | Phosphorylation | score4 | HPRD PRO | 19413330, 19015317, 20016069, ... | ||
S1043 | Phosphorylation | PR:000003271 (CDK1) | score3 | PRO | 19015317, 20016069 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000028798 (hBUB1B/iso:1/Ac:1) | acK250 | PR:000012332 (KAT2B) | PRO | 19407811 | |
PR:000035362 (hBUB1B/Phos:1) | pT620 | PR:000003271 (CDK1) | PRO | 17785528 | |
PR:000035432 (hBUB1B/Phos:3) | pT608 | PRO | 10593653, 10749118, 22801780 | ||
PR:000035435 (hBUB1B/Phos:4) | pS543,pS670,pS1043 | PR:000003271 (CDK1) | PRO | 19015317, 20016069 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000035362 (hBUB1B/Phos:1) | increased Interaction | PR:P53350 (hPLK1) | PRO | 17785528 | |
PR:000035369 (hCDC20/PhosRes-) | Interaction | PR:O60566 (hBUB1B) | PRO | 15525512 | |
PR:000035371 (hCDC20/Phos:1) | Interaction | PR:O60566 (hBUB1B) | PRO | 15525512 | |
PR:000035373 (hBUB1B/PhosRes-) | Interaction | PR:000035669 (hPLK1/PhosRes-) | PRO | 19503101 | |
PR:000035428 (hBUB1B/Phos:2) | increased Interaction | PR:Q15172 (hPPP2R5A) | PRO | 23079597 | |
PR:000035428 (hBUB1B/Phos:2) | increased Interaction | PR:O43683 (hBUB1) | PRO | 11792804 | |
PR:000035428 (hBUB1B/Phos:2) | Interaction | PR:Q12834 (hCDC20) | PRO | 11030144 | |
PR:000035442 (hCDC20/Phos:3) | decreased Interaction | PR:O60566 (hBUB1B) | PRO | 22566641 | |
PR:000035444 (frog-CDC20/Phos:4) | increased Interaction | PR:O60566 (hBUB1B) | PRO | 12855955 | |
PR:000035449 (hCDC27/Phos:1) | increased Interaction | PR:O60566 (hBUB1B) | PRO | 11030144 | |
PR:O43683 (hBUB1) | Interaction | PR:O60566 (hBUB1B) | PRO | 11792804 | |
PR:O43684 (hBUB3) | Interaction | PR:O60566 (hBUB1B) | PRO | 17785528 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q92769 (hHDAC2) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:P09874 (hPARP1) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:000035449 (hCDC27/Phos:1) | PRO | 11030144 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q02224 (hCENPE) | PRO | 17785528 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q9H081 (hMIS12) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:P51587 (hBRCA2) | PRO | 10749118 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q9NQS7 (hINCENP) | PRO | 16760428, 17785528 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q13042 (hCDC16) | PRO | 11030144 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q13547 (hHDAC1) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:000035450 (hCDC27/PhosRes-) | PRO | 11030144 | |
PR:O60566 (hBUB1B) | Interaction | PR:P25054 (hAPC) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q9H4B4 (hPLK3) | PRO | 15190214 | |
PR:O60566 (hBUB1B) | Interaction | PR:O43683 (hBUB1) | PRO | 11792804 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q96IF1 (hAJUBA) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q9UJX3 (hANAPC7) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 20624902 | |
PR:O60566 (hBUB1B) | Interaction | PR:O15379 (hHDAC3) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:O76070 (hSNCG) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:P04637-1 (hTP53/iso:1) | PRO | 17671183 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q12834 (hCDC20) | PRO | 11030144, 20624902 | |
PR:O60566 (hBUB1B) | Interaction | PR:Q9UJX5 (hANAPC4) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q15013 (hMAD2L1BP) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q92831 (hKAT2B) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q8NG31 (hKNL1) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:O43684 (hBUB3) | PRO | 20016069 | |
PR:O60566 (hBUB1B) | Interaction | PR:P04049 (hRAF1) | PRO | 20703093 | |
PR:O60566 (hBUB1B) | Interaction | PR:O95997 (hPTTG1) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:O15350 (hTP73) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:P63010 (hAP2B1) | PRO | ||
PR:O60566 (hBUB1B) | Interaction | PR:Q96GD4 (hAURKB) | PRO | ||
PR:P04049 (hRAF1) | Interaction | PR:O60566 (hBUB1B) | PRO | 20703093 | |
PR:P04637-1 (hTP53/iso:1) | Interaction | PR:O60566 (hBUB1B) | PRO | 17671183 | |
PR:P51587 (hBRCA2) | Interaction | PR:O60566 (hBUB1B) | PRO | 10749118 | |
PR:P53350 (hPLK1) | Interaction | PR:O60566 (hBUB1B) | PRO | 17376779 | |
PR:Q02224 (hCENPE) | Interaction | PR:O60566 (hBUB1B) | PRO | 17785528 | |
PR:Q12834 (hCDC20) | Interaction | PR:O60566 (hBUB1B) | PRO | 11030144, 20624902 | |
PR:Q13042 (hCDC16) | Interaction | PR:O60566 (hBUB1B) | PRO | 11030144 | |
PR:Q13257 (hMAD2L1) | Interaction | PR:O60566 (hBUB1B) | PRO | 20624902 | |
PR:Q15172 (hPPP2R5A) | Interaction | PR:000035428 (hBUB1B/Phos:2) | PRO | 23079597 | |
PR:Q5FBB7 (hSGO1) | Interaction | PR:O60566 (hBUB1B) | PRO | ||
PR:Q8NG31 (hKNL1) | Interaction | PR:O60566 (hBUB1B) | PRO | ||
PR:Q96GD4 (hAURKB) | Interaction | PR:O60566 (hBUB1B) | PRO | ||
PR:Q9H4B4 (hPLK3) | Interaction | PR:O60566 (hBUB1B) | PRO | 15190214 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S16 | F16 | Biomuta | [ cosmic ] | |
T40 | M40 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
Y64 | N64 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K113 | T113 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S384 | R384 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S521 | Y521 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S574 | F574 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
T620 | S620 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
S670 | I670 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S670 | R670 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S682 | F682 | Biomuta | [ cosmic ] | |
S697 | F697 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T710 | S710 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S797 | C797 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
C841 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
N983 | T983 | Biomuta | DOID:363 / uterine cancer [ icgc ] |