Protein Information

Cytoscape View

UniProt AC / UniProt ID O60566 / BUB1B_HUMAN
Protein Name Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Gene Name Name: BUB1B
Organism Homo sapiens (Human)

PRO ID PR:O60566
DAG View
PRO Name mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human.
Short Label hBUB1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O60566 (BUB1B) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
K250 Acetylation IntAct   PhosphoSitePlus   UniProt 19407811
K250 Sumoylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S367 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
T368 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
S435 Phosphorylation P33981 (TTK) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22067460, 19015317, 23186163
K438 Ubiquitination PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S537 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K539 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
S543 Phosphorylation P06493 (CDK1) , P33981 (TTK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 22067460, ...20016069, 19015317
S574 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T600 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus   RLIMS-P 22801780
T620 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17785528
K629 Ubiquitination PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
Y660 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus   UniProt 23186163
K667 Ubiquitination PhosphoSitePlus
K668 Acetylation IntAct 24825348
K668 Ubiquitination PhosphoSitePlus
S670 Phosphorylation P33981 (TTK) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 23345399, ...27350047, 19282664, 22067460, 18669648, 20016069, 19015317, 20068231
S676 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23345399, 27350047, 18824563, ...32286328, 17785528
T680 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor 30598363, 32286328, 23079597, ...27350047
S683 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus   UniProt 23186163
K699 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
T710 Phosphorylation PhosphoSitePlus
S720 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S733 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K757 Ubiquitination PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
T792 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   Signor   UniProt 17376779
S797 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
R919 Methylation PhosphoSitePlus
N983 N-Glycosylation GlyGen 29741879
K988 Ubiquitination PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
T1008 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   Signor   UniProt 17376779
K1037 Ubiquitination PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
T1042 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1043 Phosphorylation P06493 (CDK1) , P33981 (TTK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22067460, 19015317, 20016069
Site PTM Type PTM Enzyme Score Source PMID
K250 Acetylation PR:000012332 (KAT2B) PRO 19407811
T434 Phosphorylation HPRD 20068231
S435 Phosphorylation HPRD 18669648, 20068231
S543 Phosphorylation PR:000003271 (CDK1) HPRD   PRO 19007248, 19691289, 19651622, ...20016069, 19015317, 20068231
T608 Phosphorylation PRO 22801780, 10593653, 10749118
T620 Phosphorylation PR:000003271 (CDK1) PRO 17785528
S670 Phosphorylation PR:000003271 (CDK1) HPRD   PRO 18691976, 19691289, 19651622, ...18669648, 20016069, 19015317, 20068231
T1042 Phosphorylation HPRD 17322306, 20068231
S1043 Phosphorylation PR:000003271 (CDK1) HPRD   PRO 19413330, 19015317, 20016069, ...20068231


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028798 (hBUB1B/iso:1/Ac:1) acK250 PR:000012332 (KAT2B) PRO 19407811
PR:000035362 (hBUB1B/Phos:1) pT620 PR:000003271 (CDK1) PRO 17785528
PR:000035432 (hBUB1B/Phos:3) pT608 PRO 10593653, 10749118, 22801780
PR:000035435 (hBUB1B/Phos:4) pS543,pS670,pS1043 PR:000003271 (CDK1) PRO 19015317, 20016069

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035362 (hBUB1B/Phos:1) increased Interaction PR:P53350 (hPLK1) PRO 17785528
PR:000035369 (hCDC20/PhosRes-) Interaction PR:O60566 (hBUB1B) PRO 15525512
PR:000035371 (hCDC20/Phos:1) Interaction PR:O60566 (hBUB1B) PRO 15525512
PR:000035373 (hBUB1B/PhosRes-) Interaction PR:000035669 (hPLK1/PhosRes-) PRO 19503101
PR:000035428 (hBUB1B/Phos:2) increased Interaction PR:Q15172 (hPPP2R5A) PRO 23079597
PR:000035428 (hBUB1B/Phos:2) Interaction PR:Q12834 (hCDC20) PRO 11030144
PR:000035428 (hBUB1B/Phos:2) increased Interaction PR:O43683 (hBUB1) PRO 11792804
PR:000035442 (hCDC20/Phos:3) decreased Interaction PR:O60566 (hBUB1B) PRO 22566641
PR:000035444 (frog-CDC20/Phos:4) increased Interaction PR:O60566 (hBUB1B) PRO 12855955
PR:000035449 (hCDC27/Phos:1) increased Interaction PR:O60566 (hBUB1B) PRO 11030144
PR:O43683 (hBUB1) Interaction PR:O60566 (hBUB1B) PRO 11792804
PR:O43684 (hBUB3) Interaction PR:O60566 (hBUB1B) PRO 17785528
PR:O60566 (hBUB1B) Interaction PR:Q92769 (hHDAC2) PRO
PR:O60566 (hBUB1B) Interaction PR:P09874 (hPARP1) PRO
PR:O60566 (hBUB1B) Interaction PR:Q9H081 (hMIS12) PRO
PR:O60566 (hBUB1B) Interaction PR:000035450 (hCDC27/PhosRes-) PRO 11030144
PR:O60566 (hBUB1B) Interaction PR:Q02224 (hCENPE) PRO 17785528
PR:O60566 (hBUB1B) Interaction PR:Q9NQS7 (hINCENP) PRO 16760428, 17785528
PR:O60566 (hBUB1B) Interaction PR:P04637-1 (hTP53/iso:1) PRO 17671183
PR:O60566 (hBUB1B) Interaction PR:Q9H4B4 (hPLK3) PRO 15190214
PR:O60566 (hBUB1B) Interaction PR:P25054 (hAPC) PRO
PR:O60566 (hBUB1B) Interaction PR:P51587 (hBRCA2) PRO 10749118
PR:O60566 (hBUB1B) Interaction PR:O43683 (hBUB1) PRO 11792804
PR:O60566 (hBUB1B) Interaction PR:Q96IF1 (hAJUBA) PRO
PR:O60566 (hBUB1B) Interaction PR:Q9UJX3 (hANAPC7) PRO
PR:O60566 (hBUB1B) Interaction PR:000035449 (hCDC27/Phos:1) PRO 11030144
PR:O60566 (hBUB1B) Interaction PR:O15379 (hHDAC3) PRO
PR:O60566 (hBUB1B) Interaction PR:P04049 (hRAF1) PRO 20703093
PR:O60566 (hBUB1B) Interaction PR:O76070 (hSNCG) PRO
PR:O60566 (hBUB1B) Interaction PR:Q15013 (hMAD2L1BP) PRO
PR:O60566 (hBUB1B) Interaction PR:Q12834 (hCDC20) PRO 11030144, 20624902
PR:O60566 (hBUB1B) Interaction PR:Q9UJX5 (hANAPC4) PRO
PR:O60566 (hBUB1B) Interaction PR:Q13257 (hMAD2L1) PRO 20624902
PR:O60566 (hBUB1B) Interaction PR:P63010 (hAP2B1) PRO
PR:O60566 (hBUB1B) Interaction PR:O43684 (hBUB3) PRO 20016069
PR:O60566 (hBUB1B) Interaction PR:Q8NG31 (hKNL1) PRO
PR:O60566 (hBUB1B) Interaction PR:Q13042 (hCDC16) PRO 11030144
PR:O60566 (hBUB1B) Interaction PR:Q92831 (hKAT2B) PRO
PR:O60566 (hBUB1B) Interaction PR:Q96GD4 (hAURKB) PRO
PR:O60566 (hBUB1B) Interaction PR:O15350 (hTP73) PRO
PR:O60566 (hBUB1B) Interaction PR:O95997 (hPTTG1) PRO
PR:O60566 (hBUB1B) Interaction PR:Q13547 (hHDAC1) PRO
PR:P04049 (hRAF1) Interaction PR:O60566 (hBUB1B) PRO 20703093
PR:P04637-1 (hTP53/iso:1) Interaction PR:O60566 (hBUB1B) PRO 17671183
PR:P51587 (hBRCA2) Interaction PR:O60566 (hBUB1B) PRO 10749118
PR:P53350 (hPLK1) Interaction PR:O60566 (hBUB1B) PRO 17376779
PR:Q02224 (hCENPE) Interaction PR:O60566 (hBUB1B) PRO 17785528
PR:Q12834 (hCDC20) Interaction PR:O60566 (hBUB1B) PRO 11030144, 20624902
PR:Q13042 (hCDC16) Interaction PR:O60566 (hBUB1B) PRO 11030144
PR:Q13257 (hMAD2L1) Interaction PR:O60566 (hBUB1B) PRO 20624902
PR:Q15172 (hPPP2R5A) Interaction PR:000035428 (hBUB1B/Phos:2) PRO 23079597
PR:Q5FBB7 (hSGO1) Interaction PR:O60566 (hBUB1B) PRO
PR:Q8NG31 (hKNL1) Interaction PR:O60566 (hBUB1B) PRO
PR:Q96GD4 (hAURKB) Interaction PR:O60566 (hBUB1B) PRO
PR:Q9H4B4 (hPLK3) Interaction PR:O60566 (hBUB1B) PRO 15190214

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y64 N64 Biomuta DOID:0070003 / blastoma [ cosmic ]
S83 I83 Biomuta DOID:3571 / liver cancer [ icgc ]
K113 T113 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S384 G384 Biomuta DOID:263 / kidney cancer [ tcga ]
S384 R384 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S521 Y521 Biomuta DOID:363 / uterine cancer [ tcga ]
T620 S620 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S670 R670 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T710 S710 Biomuta DOID:1324 / lung cancer [ tcga ]
S797 C797 Biomuta DOID:1324 / lung cancer [ tcga ]
N983 T983 Biomuta DOID:363 / uterine cancer [ tcga ]
K1037 N1037 Biomuta DOID:3571 / liver cancer [ icgc ]