iPTMnet Report for O60313 (OPA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60313 / OPA1_HUMAN
Protein Name Dynamin-like 120 kDa protein, mitochondrial precursor
Gene Name Name: OPA1
Synonyms:KIAA0567;
Organism Homo sapiens (Human)

PRO ID PR:O60313
DAG View
PRO Name dynamin-like 120 kDa protein, mitochondrial (human)
Definition A dynamin-like 120 kDa protein, mitochondrial that is encoded in the genome of human.
Short Label hOPA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60313 (OPA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus   UniProt 19608861
K228 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
R733 Methylation PhosphoSitePlus
K772 Acetylation PhosphoSitePlus
Y808 Phosphorylation PhosphoSitePlus
T815 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
R824 Methylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K834 Acetylation PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
K926 Acetylation PhosphoSitePlus
T929 Phosphorylation PhosphoSitePlus
K931 Acetylation PhosphoSitePlus
K940 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
T890 Phosphorylation HPRD 18691976
T929 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
T945 Phosphorylation HPRD 18691976
T984 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
T908 Phosphorylation HPRD 18691976
T947 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
T854 Phosphorylation HPRD 18691976
T893 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
Y235 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
T927 Phosphorylation HPRD 18691976
T966 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 17924679
S22 Phosphorylation HPRD 17924679
S107 Phosphorylation HPRD 18452278
T114 Phosphorylation HPRD 18452278
T891 Phosphorylation HPRD 18691976
T930 Phosphorylation HPRD 15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S107 L107 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ]
Y268 D268 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S383 T383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T405 A405 Biomuta DOID:4159 / skin cancer [ cosmic ]
S440 F440 Biomuta DOID:4159 / skin cancer [ cosmic ]
K568 N568 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S607 T607 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S682 F682 Biomuta DOID:4159 / skin cancer [ cosmic ]
K699 R699 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S708 N708 Biomuta DOID:1324 / lung cancer [ cosmic ]
R824 Q824 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K834 T834 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K923 N923 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K926 E926 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ]