iPTMnet Report for O60313 (OPA1)
Protein Information
UniProt AC / UniProt ID | O60313 / OPA1_HUMAN |
Protein Name | Dynamin-like 120 kDa protein, mitochondrial precursor |
Gene Name | Name: OPA1 Synonyms:KIAA0567; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O60313 |
PRO Name | dynamin-like 120 kDa protein, mitochondrial (human) |
Definition | A dynamin-like 120 kDa protein, mitochondrial that is encoded in the genome of human. |
Short Label | hOPA1 |
Category | organism-gene |
O60313 (OPA1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
S107 | Phosphorylation | score1 | PhosphoSitePlus | |||
T114 | Phosphorylation | score1 | PhosphoSitePlus | |||
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y132 | Phosphorylation | score1 | PhosphoSitePlus | |||
K154 | Ubiquitination | score1 | PhosphoSitePlus | |||
K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
K228 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y268 | Phosphorylation | score1 | PhosphoSitePlus | |||
S298 | Phosphorylation | score1 | PhosphoSitePlus | |||
K301 | Ubiquitination | score1 | PhosphoSitePlus | |||
T302 | Phosphorylation | score1 | PhosphoSitePlus | |||
S344 | Phosphorylation | score1 | PhosphoSitePlus | |||
S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
T351 | Phosphorylation | score1 | PhosphoSitePlus | |||
K352 | Ubiquitination | score1 | PhosphoSitePlus | |||
S383 | Phosphorylation | score1 | PhosphoSitePlus | |||
K387 | Ubiquitination | score1 | PhosphoSitePlus | |||
T405 | Phosphorylation | score1 | PhosphoSitePlus | |||
S440 | Phosphorylation | score1 | PhosphoSitePlus | |||
K474 | Ubiquitination | score1 | PhosphoSitePlus | |||
S478 | Phosphorylation | score1 | PhosphoSitePlus | |||
K489 | Ubiquitination | score1 | PhosphoSitePlus | |||
K527 | Ubiquitination | score1 | PhosphoSitePlus | |||
K530 | Ubiquitination | score1 | PhosphoSitePlus | |||
K535 | Ubiquitination | score1 | PhosphoSitePlus | |||
K568 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y582 | Phosphorylation | score1 | PhosphoSitePlus | |||
K598 | Ubiquitination | score1 | PhosphoSitePlus | |||
S607 | Phosphorylation | score1 | PhosphoSitePlus | |||
T612 | Phosphorylation | score1 | PhosphoSitePlus | |||
K663 | Ubiquitination | score1 | PhosphoSitePlus | |||
S682 | Phosphorylation | score1 | PhosphoSitePlus | |||
K699 | Ubiquitination | score1 | PhosphoSitePlus | |||
S708 | Phosphorylation | score1 | PhosphoSitePlus | |||
K713 | Ubiquitination | score1 | PhosphoSitePlus | |||
R733 | Methylation | score1 | PhosphoSitePlus | |||
K772 | Acetylation | score1 | PhosphoSitePlus | |||
Y808 | Phosphorylation | score1 | PhosphoSitePlus | |||
T815 | Phosphorylation | score1 | PhosphoSitePlus | |||
T816 | Phosphorylation | score1 | PhosphoSitePlus | |||
R824 | Methylation | score1 | PhosphoSitePlus | |||
S831 | Phosphorylation | score1 | PhosphoSitePlus | |||
K834 | Acetylation | score1 | PhosphoSitePlus | |||
K834 | Ubiquitination | score1 | PhosphoSitePlus | |||
K911 | Ubiquitination | score1 | PhosphoSitePlus | |||
K923 | Ubiquitination | score1 | PhosphoSitePlus | |||
K926 | Acetylation | score1 | PhosphoSitePlus | |||
T929 | Phosphorylation | score1 | PhosphoSitePlus | |||
K931 | Acetylation | score1 | PhosphoSitePlus | |||
K940 | Ubiquitination | score1 | PhosphoSitePlus | |||
K948 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 17924679 | ||
S22 | Phosphorylation | score0 | HPRD | 17924679 | ||
S107 | Phosphorylation | score0 | HPRD | 18452278 | ||
T114 | Phosphorylation | score0 | HPRD | 18452278 | ||
T890 | Phosphorylation | score0 | HPRD | 18691976 | ||
T929 | Phosphorylation | score0 | HPRD | 15144186 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 17924679 | ||
S22 | Phosphorylation | score0 | HPRD | 17924679 | ||
S107 | Phosphorylation | score0 | HPRD | 18452278 | ||
T114 | Phosphorylation | score0 | HPRD | 18452278 | ||
T945 | Phosphorylation | score0 | HPRD | 18691976 | ||
T984 | Phosphorylation | score0 | HPRD | 15144186 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 17924679 | ||
S22 | Phosphorylation | score0 | HPRD | 17924679 | ||
S107 | Phosphorylation | score0 | HPRD | 18452278 | ||
T114 | Phosphorylation | score0 | HPRD | 18452278 | ||
T908 | Phosphorylation | score0 | HPRD | 18691976 | ||
T947 | Phosphorylation | score0 | HPRD | 15144186 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 17924679 | ||
S22 | Phosphorylation | score0 | HPRD | 17924679 | ||
S107 | Phosphorylation | score0 | HPRD | 18452278 | ||
T114 | Phosphorylation | score0 | HPRD | 18452278 | ||
T854 | Phosphorylation | score0 | HPRD | 18691976 | ||
T893 | Phosphorylation | score0 | HPRD | 15144186 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 17924679 | ||
S22 | Phosphorylation | score0 | HPRD | 17924679 | ||
S107 | Phosphorylation | score0 | HPRD | 18452278 | ||
T114 | Phosphorylation | score0 | HPRD | 18452278 | ||
Y235 | Phosphorylation | score1 | PhosphoSitePlus | |||
K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
T927 | Phosphorylation | score0 | HPRD | 18691976 | ||
T966 | Phosphorylation | score0 | HPRD | 15144186 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S107 | L107 | Biomuta | DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] | |
Y268 | D268 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
S383 | T383 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T405 | A405 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S440 | F440 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K568 | N568 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
S607 | T607 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S682 | F682 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K699 | R699 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
S708 | N708 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
R824 | Q824 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
K834 | T834 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K923 | N923 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
K926 | E926 | Biomuta | DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ] |