iPTMnet Report for O60285 (NUAK1)
Protein Information
| UniProt AC / UniProt ID | O60285 / NUAK1_HUMAN |
| Protein Name | NUAK family SNF1-like kinase 1 |
| Gene Name | Name: NUAK1 Synonyms:ARK5,KIAA0537,OMPHK1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O60285 |
| PRO Name | NUAK family SNF1-like kinase 1 (human) |
| Definition | A NUAK family SNF1-like kinase 1 that is encoded in the genome of human. |
| Short Label | hNUAK1 |
| Category | organism-gene |
DAG ViewO60285 (NUAK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19369195 | ||
| S22 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| Y141 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y143 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S145 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T211 | Phosphorylation | Q15831 (STK11) , Q9Y2H1 (STK38L) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 19369195, 14976552, 16488889, ... | |
| R284 | Methylation | score1 | PhosphoSitePlus | |||
| T356 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S388 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24785407 | ||
| S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S445 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24785407 | ||
| S455 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 19369195, 24785407 | ||
| S459 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S476 | Phosphorylation | P53350 (PLK1) | score3 | PhosphoSitePlus RLIMS-P+ | 24785407 | |
| S480 | Phosphorylation | P53350 (PLK1) | score3 | PhosphoSitePlus RLIMS-P+ | 24785407 | |
| S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S516 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S518 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S562 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S600 | Phosphorylation | P31749 (AKT1) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 15060171, 12409306 | |
| S603 | Phosphorylation | score1 | PhosphoSitePlus |
O60285 (NUAK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O14974 (PPP1R12A) | S445 | score4 | PhosphoSitePlus RLIMS-P+ Signor | 20354225, 24171924 | |
| O14974 (PPP1R12A) | S472 | score3 | PhosphoSitePlus Signor | 20354225 | |
| O14974 (PPP1R12A) | S910 | score3 | PhosphoSitePlus Signor | 20354225 | |
| O95835 (LATS1) | S464 | score3 | neXtProt PhosphoSitePlus Signor | 19927127 | |
| P04637 (TP53) | S15 | score3 | neXtProt PhosphoSitePlus Signor | 21317932 | |
| P04637 (TP53) | S392 | score3 | neXtProt PhosphoSitePlus Signor | 21317932 | |
| P55212 (CASP6) | S257 | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus | 15273717 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048647 (hNUAK1/Phos:1) | pT211 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O60285 (NUAK1) | S445 | P53350 (PLK1) | unknown | eFIP | 24785407 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T211 | M211 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| R284 | P284 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T356 | M356 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| S455 | N455 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S459 | L459 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] | |
| S476 | L476 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S603 | F603 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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