iPTMnet Report for O60285 (NUAK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60285 / NUAK1_HUMAN
Protein Name NUAK family SNF1-like kinase 1
Gene Name Name: NUAK1
Synonyms:ARK5,KIAA0537,OMPHK1;
Organism Homo sapiens (Human)

PRO ID PR:O60285
DAG View
PRO Name NUAK family SNF1-like kinase 1 (human)
Definition A NUAK family SNF1-like kinase 1 that is encoded in the genome of human.
Short Label hNUAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60285 (NUAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19369195
S22 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y141 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T211 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 14976552, 16488889, ...21317932, 19927127, 20354225, 29106388
T211 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 19927127, 14976552
T211 Phosphorylation Q9Y2H1 (STK38L) PhosphoSitePlus 16488889
R284 Methylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus   RLIMS-P 24785407
S444 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   RLIMS-P 24785407
S455 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19369195, 24785407
S459 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus   RLIMS-P+ 24785407
S476 Phosphorylation P53350 (PLK1) RLIMS-P+ 24785407
S480 Phosphorylation PhosphoSitePlus   RLIMS-P+ 24785407
S480 Phosphorylation P53350 (PLK1) RLIMS-P+ 24785407
S499 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S600 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15060171, 12409306
S600 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 15060171, 12409306
S603 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S564 Phosphorylation HPRD 17081983
Y565 Phosphorylation HPRD 17081983


O60285 (NUAK1) as PTM Enzyme



Substrate Site Score Source PMID
O14974 (PPP1R12A) S445 PhosphoSitePlus   RLIMS-P+   Signor 20354225, 24171924
O14974 (PPP1R12A) S472 PhosphoSitePlus   Signor 20354225
O14974 (PPP1R12A) S910 PhosphoSitePlus   Signor 20354225
O95835 (LATS1) S464 neXtProt   PhosphoSitePlus   Signor 19927127
P04637 (TP53) S15 neXtProt   PhosphoSitePlus   Signor 21317932
P04637 (TP53) S392 neXtProt   PhosphoSitePlus   Signor 21317932
P55212 (CASP6) S257 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 15273717


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048647 (hNUAK1/Phos:1) pT211 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60285 (NUAK1) S445 P53350 (PLK1) unknown eFIP 24785407


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T211 M211 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R284 P284 Biomuta DOID:3571 / liver cancer [ cosmic ]
T356 M356 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S455 N455 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S459 L459 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S476 L476 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S603 F603 Biomuta DOID:4159 / skin cancer [ cosmic ]