iPTMnet Report for O60239 (SH3BP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60239 / 3BP5_HUMAN
Protein Name SH3 domain-binding protein 5
Gene Name Name: SH3BP5
Synonyms:SAB;
Organism Homo sapiens (Human)

PRO ID PR:O60239
DAG View
PRO Name SH3 domain-binding protein 5 (human)
Definition An SH3 domain-binding protein 5 that is encoded in the genome of human.
Short Label hSH3BP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60239 (SH3BP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Methylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S351 Phosphorylation P53778 (MAPK12) , P45984 (MAPK9) neXtProt 15158451
S375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
K432 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S351 Phosphorylation P45984 (MAPK9) , P53778 (MAPK12) HPRD 15158451
S421 Phosphorylation P53778 (MAPK12) , P45984 (MAPK9) HPRD 19413330, 18669648, 15158451, ...16964243, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S194 Phosphorylation P45984 (MAPK9) , P53778 (MAPK12) HPRD 15158451
S264 Phosphorylation P45984 (MAPK9) , P53778 (MAPK12) HPRD 19413330, 18669648, 15158451, ...16964243, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K99 E99 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y101 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K133 N133 Biomuta DOID:3571 / liver cancer [ cosmic ]
K209 R209 Biomuta DOID:184 / bone cancer [ cosmic ]
K227 E227 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K227 N227 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K244 N244 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K248 N248 Biomuta DOID:363 / uterine cancer [ icgc ]
S375 A375 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S376 Y376 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K415 Q415 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]