iPTMnet Report for O43933 (PEX1)
Protein Information
| UniProt AC / UniProt ID | O43933 / PEX1_HUMAN |
| Protein Name | Peroxisomal ATPase PEX1 |
| Gene Name | Name: PEX1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43933 |
| PRO Name | peroxisomal ATPase PEX1 (human) |
| Definition | A peroxisomal ATPase PEX1 that is encoded in the genome of human. |
| Short Label | hPEX1 |
| Category | organism-gene |
O43933 (PEX1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K191 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S264 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K274 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S278 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K291 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K337 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K342 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K349 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S354 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K357 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K402 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K411 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T438 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K446 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K455 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K513 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S585 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K610 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K614 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K619 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K630 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K756 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K763 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K774 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K806 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T810 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T811 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K816 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K833 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K841 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y880 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T885 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K887 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K906 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K913 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K933 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1001 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1179 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S1181 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 17525332, 23186163, 18669648 | ||
| T1189 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1201 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1204 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1207 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1209 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
| S1211 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| S1216 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1224 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1270 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K198 | R198 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y202 | H202 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| K211 | R211 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K274 | R274 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K337 | M337 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K357 | N357 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T438 | N438 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S541 | N541 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S585 | C585 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K614 | E614 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] | |
| K763 | N763 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K833 | T833 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K887 | N887 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K906 | R906 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S1216 | Y1216 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
DAG View