iPTMnet Report for O43791 (SPOP)
Protein Information
| UniProt AC / UniProt ID | O43791 / SPOP_HUMAN |
| Protein Name | Speckle-type POZ protein |
| Gene Name | Name: SPOP |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43791 |
| PRO Name | speckle-type POZ protein (human) |
| Definition | A speckle-type POZ protein that is encoded in the genome of human. |
| Short Label | hSPOP |
| Category | organism-gene |
DAG ViewO43791 (SPOP) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C44 | Methylation | score1 | IEDB | 31844290 | ||
| S54 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S96 | O-Glycosylation | score2 | GlyGen | 36604567 | ||
| K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S119 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K215 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K268 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K339 | Acetylation | score1 | PhosphoSitePlus | |||
| C361 | Methylation | score1 | IEDB | 31844290 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9H9S0 (NANOG) | S68 | O43791 (SPOP) | inhibited_association | eFIP | 30595535 | |
| Phosphorylation | Q9Y6Q9 (NCOA3) | S102 | O43791 (SPOP) | unknown | eFIP | 21577200 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000027692 (hNCOA3/iso:1/Phos:1) | Interaction | PR:O43791 (hSPOP) | PRO | 21577200 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| C44 | F44 | Biomuta | DOID:10283 / prostate cancer [ icgc ] |
