Protein Information

Cytoscape View


UniProt AC / UniProt ID O43791 / SPOP_HUMAN
Protein Name Speckle-type POZ protein
Gene Name Name: SPOP
Organism Homo sapiens (Human)

PRO ID PR:O43791
DAG View
PRO Name speckle-type POZ protein (human)
Definition A speckle-type POZ protein that is encoded in the genome of human.
Short Label hSPOP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43791 (SPOP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K339 Acetylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H9S0 (NANOG) S68 O43791 (SPOP) inhibited_association eFIP 30595535
Phosphorylation Q9Y6Q9 (NCOA3) S102 O43791 (SPOP) unknown eFIP 21577200


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027692 (hNCOA3/iso:1/Phos:1) Interaction PR:O43791 (hSPOP) PRO 21577200


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K279 N279 Biomuta DOID:1324 / lung cancer [ cosmic ]