iPTMnet Report for O43791 (SPOP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43791 / SPOP_HUMAN
Protein Name Speckle-type POZ protein
Gene Name Name: SPOP
Organism Homo sapiens (Human)

PRO ID PR:O43791
DAG View
PRO Name speckle-type POZ protein (human)
Definition A speckle-type POZ protein that is encoded in the genome of human.
Short Label hSPOP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43791 (SPOP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S33 Phosphorylation RLIMS-P 33158056
S54 Phosphorylation PhosphoSitePlus
T56 Phosphorylation RLIMS-P 33158056
K64 Ubiquitination PhosphoSitePlus
S105 Phosphorylation RLIMS-P 33158056
K110 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K339 Acetylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H9S0 (NANOG) S68 O43791 (SPOP) inhibited_association eFIP 30595535
Phosphorylation Q9Y6Q9 (NCOA3) S102 O43791 (SPOP) unknown eFIP 21577200


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027692 (hNCOA3/iso:1/Phos:1) Interaction PR:O43791 (hSPOP) PRO 21577200


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 F105 Biomuta DOID:1909 / melanoma [ tcga ]
S119 G119 Biomuta DOID:363 / uterine cancer [ cosmic ]
S119 N119 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K279 N279 Biomuta DOID:1324 / lung cancer [ cosmic ]