Protein Information

Cytoscape View


UniProt AC / UniProt ID O43593 / HAIR_HUMAN
Protein Name Lysine-specific demethylase hairless
Gene Name Name: HR
Organism Homo sapiens (Human)

PRO ID PR:O43593
DAG View
PRO Name lysine-specific demethylase hairless (human)
Definition A lysine-specific demethylase hairless that is encoded in the genome of human.
Short Label hHR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43593 (HR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
R574 Methylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T610 Phosphorylation PhosphoSitePlus
T631 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K733 Sumoylation PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S316 C316 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S416 I416 Biomuta DOID:3070 / malignant glioma [ tcga ]
R574 W574 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]