iPTMnet Report for O43559 (FRS3)
Protein Information
| UniProt AC / UniProt ID | O43559 / FRS3_HUMAN |
| Protein Name | Fibroblast growth factor receptor substrate 3 |
| Gene Name | Name: FRS3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43559 |
| PRO Name | fibroblast growth factor receptor substrate 3 (human) |
| Definition | A fibroblast growth factor receptor substrate 3 that is encoded in the genome of human. |
| Short Label | hFRS3 |
| Category | organism-gene |
DAG ViewO43559 (FRS3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| G2 | Myristoylation | score2 | UniProt | 9660748 | ||
| S73 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S167 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y192 | Phosphorylation | score1 | PRO | |||
| Y287 | Phosphorylation | score1 | PRO | |||
| Y322 | Phosphorylation | score1 | PRO | |||
| S349 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y417 | Phosphorylation | Q16620 (NTRK2) | score3 | HPRD IntAct PRO Signor | 11432792 | |
| Y455 | Phosphorylation | Q16620 (NTRK2) | score3 | HPRD IntAct PRO PhosphoSitePlus Signor | 11432792 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047453 (hFRS3/InitMet-/Phos:1) | pY192,pY287,pY322,pY417,pY455 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S167 | R167 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y455 | H455 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| Y455 | C455 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
