iPTMnet Report for O43559 (FRS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43559 / FRS3_HUMAN
Protein Name Fibroblast growth factor receptor substrate 3
Gene Name Name: FRS3
Organism Homo sapiens (Human)

PRO ID PR:O43559
DAG View
PRO Name fibroblast growth factor receptor substrate 3 (human)
Definition A fibroblast growth factor receptor substrate 3 that is encoded in the genome of human.
Short Label hFRS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43559 (FRS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 9660748
S73 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PRO
Y287 Phosphorylation PRO
Y322 Phosphorylation PRO
S349 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation HPRD   IntAct   PRO   Signor 11432792
Y417 Phosphorylation Q16620 (NTRK2) HPRD   Signor 11432792
Y455 Phosphorylation HPRD   IntAct   PRO   PhosphoSitePlus   Signor 11432792
Y455 Phosphorylation Q16620 (NTRK2) HPRD   Signor 11432792


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047453 (hFRS3/InitMet-/Phos:1) pY192,pY287,pY322,pY417,pY455 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S167 R167 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y455 H455 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y455 C455 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]