iPTMnet Report for O43542 (XRCC3)
Protein Information
| UniProt AC / UniProt ID | O43542 / XRCC3_HUMAN |
| Protein Name | DNA repair protein XRCC3 |
| Gene Name | Name: XRCC3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43542 |
| PRO Name | DNA repair protein XRCC3 (human) |
| Definition | A DNA repair protein XRCC3 that is encoded in the genome of human. |
| Short Label | hXRCC3 |
| Category | organism-gene |
DAG ViewO43542 (XRCC3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| S23 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K172 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T189 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K197 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C221 | Methylation | score1 | IEDB | 31844290 | ||
| S225 | Phosphorylation | Q13535 (ATR) | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 17525332, 23438602 | |
| T241 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S23 | L23 | Biomuta | DOID:184 / bone cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K36 | N36 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T241 | M241 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ] |
