iPTMnet Report for O43542 (XRCC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43542 / XRCC3_HUMAN
Protein Name DNA repair protein XRCC3
Gene Name Name: XRCC3
Organism Homo sapiens (Human)

PRO ID PR:O43542
DAG View
PRO Name DNA repair protein XRCC3 (human)
Definition A DNA repair protein XRCC3 that is encoded in the genome of human.
Short Label hXRCC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43542 (XRCC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S23 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
C221 Methylation IEDB 31844290
S225 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17525332, 23438602
S225 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 23438602
T241 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 L23 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K36 N36 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T241 M241 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]