iPTMnet Report for O43541 (SMAD6)
Protein Information
| UniProt AC / UniProt ID | O43541 / SMAD6_HUMAN |
| Protein Name | Mothers against decapentaplegic homolog 6 |
| Gene Name | Name: SMAD6 Synonyms:MADH6; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43541 |
| PRO Name | mothers against decapentaplegic homolog 6 (human) |
| Definition | A smad6 that is encoded in the genome of human. |
| Short Label | hSMAD6 |
| Category | organism-gene |
DAG ViewO43541 (SMAD6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| R75 | Methylation | score1 | PhosphoSitePlus | |||
| R82 | Methylation | score1 | PhosphoSitePlus | |||
| K173 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 23455153 | ||
| S274 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S283 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S385 | O-Glycosylation | score1 | GlyGen | 31492838 | ||
| S394 | O-Glycosylation | score1 | GlyGen | 31492838 | ||
| S435 | Phosphorylation | score3 | neXtProt PhosphoSitePlus UniProt | 16491121 | ||
| S435 | Phosphorylation | P51817 (PRKX) | score3 | neXtProt PhosphoSitePlus | 16491121 | |
| K470 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S19 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:O43541-1 (hSMAD6/iso:A) | Interaction | PR:000026334 (hSMAD1/iso:1/Phos:1) | PRO | 9436979 | |
| PR:O43541-2 (hSMAD6/iso:B) | Interaction | PRO | 11284962 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S274 | F274 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S394 | I394 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
