Protein Information

Cytoscape View


UniProt AC / UniProt ID O43541 / SMAD6_HUMAN
Protein Name Mothers against decapentaplegic homolog 6
Gene Name Name: SMAD6
Synonyms:MADH6;
Organism Homo sapiens (Human)

PRO ID PR:O43541
DAG View
PRO Name mothers against decapentaplegic homolog 6 (human)
Definition A smad6 that is encoded in the genome of human.
Short Label hSMAD6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43541 (SMAD6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R75 Methylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus   UniProt 23455153
S274 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S435 Phosphorylation P51817 (PRKX) neXtProt   PhosphoSitePlus   UniProt 16491121
K470 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O43541-1 (hSMAD6/iso:A) Interaction PR:000026334 (hSMAD1/iso:1/Phos:1) PRO 9436979
PR:O43541-2 (hSMAD6/iso:B) Interaction PRO 11284962


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R75 Q75 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S274 F274 Biomuta DOID:1612 / breast cancer [ cosmic ]