iPTMnet Report for O43524 (FOXO3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43524 / FOXO3_HUMAN
Protein Name Forkhead box protein O3
Gene Name Name: FOXO3
Synonyms:FKHRL1;
Organism Homo sapiens (Human)

PRO ID PR:O43524
DAG View
PRO Name forkhead box protein O3 (human)
Definition A forkhead box protein O3 that is encoded in the genome of human.
Short Label hFOXO3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43524 (FOXO3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 22128155, 27685445, 27532863
S7 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 22128155
S12 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 29445193, 22128155
S12 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 22128155
S26 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29445193
T32 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10910908, 20525153, 24339862, ...24586650, 10102273, 22988968, 25603236, 12913110, 22928011, 32424140, 32788653, 17190839, 27602284, 29044520, 29217661, 21639915, 17077388, 23257900, 28415610, 22820736, 20950443, 18794113, 29893976, 17044646, 15207915, 29017179, 25521510, 18937079, 23568341, 27769056, 11864996, 25611382, 25503443, 24954032, 20211546, 18593906, 26674329, 26446641, 11154281, 24493314, 28036259, 24814195, 21452041, 20643654, 22848740, 31727006, 19188143, 20840854, 28398822, 31629677, 29915392, 23661003, 27856257, 10995739, 20110348
T32 Phosphorylation O00141 (SGK1) neXtProt   Signor 11154281
T32 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   Signor 18593906
T32 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10910908, 19188143, 10995739
T32 Phosphorylation P31751 (AKT2) Signor 19188143
T32 Phosphorylation Q9HBY8 (SGK2) Signor 11154281
T32 Phosphorylation Q9Y243 (AKT3) Signor 19188143
S43 Phosphorylation PhosphoSitePlus   RLIMS-P 22489133
K46 Methylation UniProt 22820736
S75 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K149 Methylation UniProt 22820736
S161 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
S173 Phosphorylation RLIMS-P 22489133
T179 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
T179 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 22137581
T179 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
Y184 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S209 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 22898666, 18394876, 16751106
S209 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus   Signor 22898666, 18394876, 16751106
S215 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 21329882, 16751106
S215 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus 16751106
S215 Phosphorylation Q8IW41 (MAPKAPK5) neXtProt 21329882
K230 Methylation UniProt 22820736
S231 Phosphorylation PhosphoSitePlus 16751106
S231 Phosphorylation Q13043 (STK4) PhosphoSitePlus 16751106
S232 Phosphorylation PhosphoSitePlus 16751106
S232 Phosphorylation Q13043 (STK4) PhosphoSitePlus 16751106
K242 Acetylation PhosphoSitePlus
S243 Phosphorylation neXtProt   PhosphoSitePlus 16751106
S243 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus 16751106
K245 Acetylation PhosphoSitePlus
S253 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17044646, 31100089, 20525153, ...24339862, 23819460, 10910908, 24586650, 10102273, 30513302, 21329882, 21291561, 26643256, 23392169, 32788653, 17190839, 33408225, 29217661, 28969041, 30671548, 23257900, 29893976, 22820736, 25521510, 31902744, 23805378, 34475505, 35874228, 27411103, 24858012, 27769056, 32424140, 32406610, 21777391, 30674870, 32347651, 25191523, 18593906, 31197106, 20661471, 26446641, 11154281, 29099866, 28036259, 31506431, 20139145, 29017179, 19188143, 31629677, 11864996, 19424579, 20110348, 27856257, 10995739, 28164237
S253 Phosphorylation O00141 (SGK1) Signor 11154281
S253 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   Signor 18593906
S253 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10910908, 10102273, 19188143, ...10995739, 11154281
S253 Phosphorylation P31751 (AKT2) Signor 19188143
S253 Phosphorylation Q96BR1 (SGK3) Signor 11154281
S253 Phosphorylation Q9HBY8 (SGK2) Signor 11154281
S253 Phosphorylation Q9Y243 (AKT3) Signor 19188143
K259 Acetylation PhosphoSitePlus
K262 Methylation UniProt 22820736
K271 Acetylation PhosphoSitePlus
K271 Methylation UniProt 22820736
S280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S284 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S284 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S286 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S286 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K290 Methylation UniProt 22820736
S294 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22128155, 33408225, 27532863, ...32587774, 30513302, 29915392, 18204439, 22489133, 19282669
S294 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 18204439, 19282669
S294 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 18204439, 22128155
S294 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 22128155
T296 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23805378, 18669648, 23186163
T307 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus   UniProt 23186163
S315 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17190839, 27856257, 24339862, ...10102273, 24586650, 19188143, 29893976, 22820736, 11864996, 26446641, 32424140, 11154281
S315 Phosphorylation O00141 (SGK1) neXtProt   PhosphoSitePlus   Signor 11154281
S315 Phosphorylation P31749 (AKT1) Signor 19188143
S315 Phosphorylation P31751 (AKT2) Signor 19188143
S315 Phosphorylation Q9Y243 (AKT3) Signor 19188143
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 32788653, 27602284, 33828192, ...29928344, 24864229, 31258486, 28398822, 30674870, 20110348, 30968255, 20661471, 31902744, 11980723
S318 Phosphorylation P48729 (CSNK1A1) Signor 20110348
T319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27602284, 33828192, 24864229, ...29928344, 31258486, 30674870, 20110348, 30968255, 11980723
S321 Phosphorylation P48729 (CSNK1A1) Signor 20110348
S325 Phosphorylation PhosphoSitePlus   RLIMS-P 28778953
S330 Phosphorylation Signor 19188143
S330 Phosphorylation Q13627 (DYRK1A) Signor 19188143
S344 Phosphorylation neXtProt   PhosphoSitePlus   Signor 18204439, 22128155, 19282669
S344 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 18204439, 19282669
S344 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 18204439, 22128155
S344 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 22128155
S355 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 22489133, 27869121
T395 Phosphorylation PhosphoSitePlus
S399 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
S399 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 22137581
S399 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
S402 Phosphorylation PhosphoSitePlus
S411 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S413 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17711846, 29269868, 23186163, ...22137581, 26373689, 22848740, 24858012, 33953705, 32406610, 31345573, 22732497
S413 Phosphorylation P54646 (PRKAA2) neXtProt   PhosphoSitePlus 17711846, 22137581
S413 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
T418 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
K419 Methylation UniProt 22820736
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S425 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18204439, 22489133, 22128155, ...19282669
S425 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 18204439, 19282669
S425 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 18204439, 22128155
S425 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 22128155
T427 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
N431 N-Glycosylation GlyGen 29741879
S439 Phosphorylation PhosphoSitePlus
T475 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S476 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S482 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S551 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
S551 Phosphorylation PhosphoSitePlus   UniProt 21329882, 23186163
S553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581, 21329882
S555 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 22137581
S555 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
K569 Acetylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus   RLIMS-P 23857333, 26470730
S574 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 23857333
S588 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17711846, 27492225, 22137581
S588 Phosphorylation P54646 (PRKAA2) neXtProt   PhosphoSitePlus 17711846, 22137581
S588 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
S626 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
S626 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 22137581
S626 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 17711846
S644 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23691078, 15084260, 19188143
S644 Phosphorylation O14920 (IKBKB) neXtProt   PhosphoSitePlus   Signor 15084260, 19188143
S644 Phosphorylation O15111 (CHUK) PhosphoSitePlus   Signor 15084260
S644 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus   Signor 23691078
S666 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...35254053, 34019948, 28657654, 29301793
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 19651622, 20068231
S12 Phosphorylation HPRD 19651622, 20068231
S26 Phosphorylation HPRD 19651622
T32 Phosphorylation HPRD 10102273, 11154281
T32 Phosphorylation O00141 (SGK1) HPRD 11154281
T32 Phosphorylation P31749 (AKT1) HPRD 10102273, 11154281
S253 Phosphorylation HPRD 20068231, 11154281
S253 Phosphorylation O00141 (SGK1) HPRD 20068231, 11154281
S253 Phosphorylation P31749 (AKT1) HPRD 20068231, 11154281
S280 Phosphorylation HPRD 19413330, 18669648
S284 Phosphorylation HPRD 19413330, 18669648, 18452278
S286 Phosphorylation HPRD 19413330
S289 Phosphorylation HPRD 20068231
S299 Phosphorylation HPRD 18669648
S315 Phosphorylation HPRD 11154281
S315 Phosphorylation O00141 (SGK1) HPRD 11154281


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43524 (FOXO3) S253 P27348 (YWHAQ) unknown eFIP 35874228