Protein Information

Cytoscape View


UniProt AC / UniProt ID O43524 / FOXO3_HUMAN
Protein Name Forkhead box protein O3
Gene Name Name: FOXO3
Synonyms:FKHRL1;
Organism Homo sapiens (Human)

PRO ID PR:O43524
DAG View
PRO Name forkhead box protein O3 (human)
Definition A forkhead box protein O3 that is encoded in the genome of human.
Short Label hFOXO3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43524 (FOXO3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 22128155, 26376801, 27532863, ...27685445
S12 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   RLIMS-P 29445193, 22128155
S26 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29445193
T32 Phosphorylation Q9Y243 (AKT3) , Q9HBY8 (SGK2) , P11309 (PIM1) , P31751 (AKT2) , P31749 (AKT1) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10910908, 20525153, 24339862, ...24586650, 22988968, 25603236, 12913110, 22928011, 32424140, 32788653, 17190839, 27602284, 29044520, 29217661, 10102273, 17077388, 21639915, 23257900, 28415610, 22820736, 20950443, 18794113, 29893976, 17044646, 15207915, 29017179, 25521510, 18937079, 23568341, 27769056, 11864996, 25611382, 25503443, 24954032, 18593906, 26674329, 26446641, 11154281, 24493314, 28036259, 24814195, 21452041, 20643654, 22848740, 31727006, 19188143, 20840854, 28398822, 31629677, 29915392, 23661003, 27856257, 10995739, 20110348
S43 Phosphorylation PhosphoSitePlus   RLIMS-P 22489133
K46 Methylation UniProt 22820736
S75 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K149 Methylation UniProt 22820736
S161 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
S173 Phosphorylation RLIMS-P 22489133
T179 Phosphorylation Q13131 (PRKAA1) , P54646 (PRKAA2) neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
Y184 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S209 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus   Signor   UniProt 22898666, 18394876, 16751106
S215 Phosphorylation Q13043 (STK4) , Q8IW41 (MAPKAPK5) neXtProt   PhosphoSitePlus   UniProt 21329882, 16751106
K230 Methylation UniProt 22820736
S231 Phosphorylation Q13043 (STK4) PhosphoSitePlus 16751106
S232 Phosphorylation Q13043 (STK4) PhosphoSitePlus 16751106
K242 Acetylation PhosphoSitePlus
S243 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus 16751106
K245 Acetylation PhosphoSitePlus
S253 Phosphorylation Q9Y243 (AKT3) , O00141 (SGK1) , Q96BR1 (SGK3) , Q9HBY8 (SGK2) , P11309 (PIM1) , P31749 (AKT1) , P31751 (AKT2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17044646, 31100089, 20525153, ...24339862, 23819460, 10910908, 24586650, 10102273, 30513302, 21329882, 26643256, 20139145, 32788653, 17190839, 33408225, 29217661, 28969041, 25271153, 30671548, 32967092, 23257900, 29893976, 22820736, 25521510, 31902744, 23805378, 23392169, 21291561, 27411103, 24858012, 27769056, 32424140, 32406610, 21777391, 30674870, 32347651, 25191523, 18593906, 31197106, 20661471, 26446641, 11154281, 29099866, 28036259, 31506431, 29017179, 10995739, 19188143, 31629677, 11864996, 19424579, 20110348, 27856257, 32928251, 28164237
K259 Acetylation PhosphoSitePlus
K262 Methylation UniProt 22820736
K271 Acetylation PhosphoSitePlus
K271 Methylation UniProt 22820736
S280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S284 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S284 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S286 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S286 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K290 Methylation UniProt 22820736
S294 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22128155, 33408225, 25271153, ...27532863, 32587774, 30513302, 29915392, 18204439, 22489133, 19282669
T296 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23805378, 18669648, 23186163
T307 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus   UniProt 23186163
S315 Phosphorylation P31749 (AKT1) , O00141 (SGK1) , P31751 (AKT2) , Q9Y243 (AKT3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17190839, 27856257, 24339862, ...10102273, 32967092, 24586650, 19188143, 29893976, 22820736, 11864996, 26446641, 32424140, 11154281
S318 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 32788653, 27602284, 33828192, ...29928344, 24864229, 31258486, 28398822, 30674870, 20110348, 30968255, 20661471, 31902744, 11980723
T319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27602284, 33828192, 24864229, ...29928344, 31258486, 30674870, 20110348, 30968255, 11980723
S325 Phosphorylation PhosphoSitePlus   RLIMS-P 28778953
S330 Phosphorylation Q13627 (DYRK1A) Signor 19188143
S344 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 18204439, 22128155, 19282669
S355 Phosphorylation PhosphoSitePlus   RLIMS-P 22489133
T395 Phosphorylation PhosphoSitePlus
S399 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
S402 Phosphorylation PhosphoSitePlus
S411 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S413 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17711846, 29269868, 23186163, ...22137581, 26373689, 22848740, 24858012, 33953705, 32406610, 31345573, 22732497
T418 O-Glycosylation GlyGen 23301498, 28657654, 29301793
K419 Methylation UniProt 22820736
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S425 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , Q16539 (MAPK14) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18204439, 22489133, 22128155, ...19282669
T427 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
N431 N-Glycosylation GlyGen 29741879
S439 Phosphorylation PhosphoSitePlus
T475 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S476 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S482 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S551 O-Glycosylation GlyGen 23301498, 28657654, 29301793
S551 Phosphorylation PhosphoSitePlus   UniProt 21329882, 23186163
S553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation Q13131 (PRKAA1) , P54646 (PRKAA2) neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581, 21329882
K569 Acetylation PhosphoSitePlus
S574 Phosphorylation P45983 (MAPK8) PhosphoSitePlus   RLIMS-P 23857333, 26470730
S588 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17711846, 27492225, 22137581
S626 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   Signor   UniProt 17711846, 22137581
S644 Phosphorylation Q14164 (IKBKE) , O15111 (CHUK) , O14920 (IKBKB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23691078, 15084260, 19188143
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 19651622, 20068231
S12 Phosphorylation HPRD 19651622, 20068231
S26 Phosphorylation HPRD 19651622
T32 Phosphorylation O00141 (SGK1) , P31749 (AKT1) HPRD 10102273, 11154281
S253 Phosphorylation O00141 (SGK1) , P31749 (AKT1) HPRD 20068231, 11154281
S280 Phosphorylation HPRD 19413330, 18669648
S284 Phosphorylation HPRD 19413330, 18669648, 18452278
S286 Phosphorylation HPRD 19413330
S289 Phosphorylation HPRD 20068231
S299 Phosphorylation HPRD 18669648
S315 Phosphorylation O00141 (SGK1) HPRD 11154281


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 C26 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S209 F209 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S209 Y209 Biomuta DOID:363 / uterine cancer [ tcga ]
S299 I299 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S315 F315 Biomuta DOID:1909 / melanoma [ tcga ]
S318 C318 Biomuta DOID:1324 / lung cancer [ cosmic ]
S330 N330 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S402 L402 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S425 F425 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S476 * Biomuta DOID:3571 / liver cancer [ icgc ]
S482 N482 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]