iPTMnet Report for O43521 (BCL2L11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43521 / B2L11_HUMAN
Protein Name Bcl-2-like protein 11
Gene Name Name: BCL2L11
Synonyms:BIM;
Organism Homo sapiens (Human)

PRO ID PR:O43521
DAG View
PRO Name Bcl-2-like protein 11 (human)
Definition A Bcl-2-like protein 11 that is encoded in the genome of human.
Short Label hBCL2L11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43521 (BCL2L11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K3 Ubiquitination PhosphoSitePlus
C12 S-Nitrosylation dbSNO 24105792
S59 Phosphorylation PhosphoSitePlus   RLIMS-P 25526094, 21247487
S69 Phosphorylation Q16539 (MAPK14) , P45983 (MAPK8) , P45984 (MAPK9) , P53779 (MAPK10) , P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28863346, 12591950, 25187648, ...18715233, 12818176, 18063582, 26245900, 26716515, 16818494, 27661108, 14681225, 17525735, 14555991, 18174237, 15486195, 26447615, 21247487
S77 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 26716515, 18220336
S87 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 16282323
S93 Phosphorylation O14965 (AURKA) PhosphoSitePlus 23912711
S94 Phosphorylation O14965 (AURKA) PhosphoSitePlus   UniProt 23912711, 23186163
Y96 Phosphorylation PhosphoSitePlus
S98 Phosphorylation O14965 (AURKA) PhosphoSitePlus 23912711
S104 Phosphorylation P45983 (MAPK8) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12591950, 12818176, 22071694
K112 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T116 Phosphorylation P53779 (MAPK10) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22742832, 12591950, 18498746, ...12818176
S118 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus 12591950, 12818176
Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation P45984 (MAPK9) , P45983 (MAPK8) , P53779 (MAPK10) HPRD 12818176
S69 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) HPRD 12818176
S77 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) , P53779 (MAPK10) HPRD 18691976, 12818176
S87 Phosphorylation PRO 16282323
S104 Phosphorylation P45983 (MAPK8) HPRD 12591950
T116 Phosphorylation P45983 (MAPK8) HPRD 12591950
S118 Phosphorylation P45983 (MAPK8) HPRD 12591950
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation P45983 (MAPK8) HPRD 12591950
S58 Phosphorylation P45983 (MAPK8) HPRD 12591950
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation P06493 (CDK1) , P45983 (MAPK8) neXtProt   phospho.ELM   PRO   PhosphoSitePlus 12591950, 22071694
T56 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) HPRD   phospho.ELM   PRO   PhosphoSitePlus 12591950
S58 Phosphorylation P53779 (MAPK10) , P45983 (MAPK8) HPRD   phospho.ELM   PRO   PhosphoSitePlus 12591950
Site PTM Type PTM Enzyme Score Source PMID
T34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 18691976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046476 (hBCL2L11/Phos:2) pS69 PRO
PR:000046477 (hBCL2L11/PhosRes+) p PRO
PR:000025727 (hBCL2L11/iso:1/Phos:1) pS87 PRO 16282323
PR:000036641 (hBCL2L11/iso:2/Phos:1) pS44,pT56,pS58 PRO 12591950


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43521 (BCL2L11) T116 P63167 (DYNLL1) unknown eFIP 22742832
Phosphorylation P10415 (BCL2) S70 O43521 (BCL2L11) increased_association eFIP 24097825


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025727 (hBCL2L11/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 16282323
PR:000036641 (hBCL2L11/iso:2/Phos:1) decreased Interaction PR:Q96QB1 (hDLC1) PRO 12591950
PR:000044746 (hBCL2L11/iso:2/UnMod) Interaction PR:Q96QB1 (hDLC1) PRO 12591950
PR:O43521-2 (hBCL2L11/iso:BimL) Interaction PR:Q07812 (hBAX) PRO 14764673


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C12 R12 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S44 R44 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S77 F77 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, icgc ]
S93 F93 Biomuta DOID:4159 / skin cancer [ cosmic ]
S94 T94 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y96 C96 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S104 R104 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K112 T112 Biomuta DOID:3571 / liver cancer [ cosmic ]