iPTMnet Report for O43521 (BCL2L11)
Protein Information
| UniProt AC / UniProt ID | O43521 / B2L11_HUMAN |
| Protein Name | Bcl-2-like protein 11 |
| Gene Name | Name: BCL2L11 Synonyms:BIM; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43521 |
| PRO Name | Bcl-2-like protein 11 (human) |
| Definition | A Bcl-2-like protein 11 that is encoded in the genome of human. |
| Short Label | hBCL2L11 |
| Category | organism-gene |
DAG ViewO43521 (BCL2L11) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Phosphorylation | score1 | PRO | ||||
| K3 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C12 | S-Nitrosylation | score0 | dbSNO | 24105792 | ||
| S59 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 25526094, 21247487 | ||
| S69 | Phosphorylation | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 28863346, 12591950, 25187648, ... | ||
| S69 | Phosphorylation | P27361 (MAPK3) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 17525735, 15486195, 14555991, ... | |
| S69 | Phosphorylation | P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 17525735, 15486195, 14555991 | |
| S69 | Phosphorylation | P45983 (MAPK8) | score4 | neXtProt Signor | 12591950, 12818176, 18174237 | |
| S69 | Phosphorylation | P45984 (MAPK9) | score2 | neXtProt | 12818176 | |
| S69 | Phosphorylation | P53779 (MAPK10) | score2 | neXtProt | 12818176 | |
| S69 | Phosphorylation | Q16539 (MAPK14) | score2 | neXtProt | 16818494 | |
| S77 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 26716515, 18220336 | ||
| S87 | Phosphorylation | score3 | neXtProt PhosphoSitePlus Signor | 16282323 | ||
| S87 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus Signor | 16282323 | |
| S93 | Phosphorylation | score2 | PhosphoSitePlus | 23912711 | ||
| S93 | Phosphorylation | O14965 (AURKA) | score2 | PhosphoSitePlus | 23912711 | |
| S94 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 23912711, 23186163 | ||
| S94 | Phosphorylation | O14965 (AURKA) | score2 | PhosphoSitePlus | 23912711 | |
| Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S98 | Phosphorylation | score2 | PhosphoSitePlus | 23912711 | ||
| S98 | Phosphorylation | O14965 (AURKA) | score2 | PhosphoSitePlus | 23912711 | |
| S104 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 12591950, 12818176, 22071694 | ||
| S104 | Phosphorylation | P06493 (CDK1) | score1 | Signor | 22071694 | |
| S104 | Phosphorylation | P45983 (MAPK8) | score3 | neXtProt | 12591950, 12818176 | |
| K112 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S113 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T116 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 22742832, 12591950, 18498746, ... | ||
| T116 | Phosphorylation | P45983 (MAPK8) | score4 | neXtProt Signor | 12591950, 12818176 | |
| T116 | Phosphorylation | P53779 (MAPK10) | score1 | Signor | 18498746 | |
| S118 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus | 12591950, 12818176 | ||
| S118 | Phosphorylation | P45983 (MAPK8) | score3 | neXtProt | 12591950, 12818176 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S59 | Phosphorylation | score1 | HPRD | 12818176 | ||
| S59 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12818176 | |
| S59 | Phosphorylation | P45984 (MAPK9) | score1 | HPRD | 12818176 | |
| S59 | Phosphorylation | P53779 (MAPK10) | score1 | HPRD | 12818176 | |
| S69 | Phosphorylation | score1 | HPRD | 12818176 | ||
| S69 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12818176 | |
| S69 | Phosphorylation | P45984 (MAPK9) | score1 | HPRD | 12818176 | |
| S69 | Phosphorylation | P53779 (MAPK10) | score1 | HPRD | 12818176 | |
| S77 | Phosphorylation | score2 | HPRD | 18691976, 12818176 | ||
| S77 | Phosphorylation | P45983 (MAPK8) | score2 | HPRD | 18691976, 12818176 | |
| S77 | Phosphorylation | P45984 (MAPK9) | score2 | HPRD | 18691976, 12818176 | |
| S77 | Phosphorylation | P53779 (MAPK10) | score2 | HPRD | 18691976, 12818176 | |
| S87 | Phosphorylation | score2 | PRO | 16282323 | ||
| S104 | Phosphorylation | score1 | HPRD | 12591950 | ||
| S104 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12591950 | |
| T116 | Phosphorylation | score1 | HPRD | 12591950 | ||
| T116 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12591950 | |
| S118 | Phosphorylation | score1 | HPRD | 12591950 | ||
| S118 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12591950 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T56 | Phosphorylation | score1 | HPRD | 12591950 | ||
| T56 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12591950 | |
| S58 | Phosphorylation | score1 | HPRD | 12591950 | ||
| S58 | Phosphorylation | P45983 (MAPK8) | score1 | HPRD | 12591950 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S44 | Phosphorylation | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus | 12591950, 22071694 | ||
| S44 | Phosphorylation | P06493 (CDK1) | score2 | PhosphoSitePlus | 22071694 | |
| S44 | Phosphorylation | P45983 (MAPK8) | score3 | phospho.ELM PhosphoSitePlus | 12591950 | |
| T56 | Phosphorylation | score3 | HPRD phospho.ELM PRO PhosphoSitePlus | 12591950 | ||
| T56 | Phosphorylation | P45983 (MAPK8) | score3 | HPRD PhosphoSitePlus | 12591950 | |
| T56 | Phosphorylation | P45984 (MAPK9) | score2 | phospho.ELM | 12591950 | |
| S58 | Phosphorylation | score3 | HPRD phospho.ELM PRO PhosphoSitePlus | 12591950 | ||
| S58 | Phosphorylation | P45983 (MAPK8) | score3 | HPRD PhosphoSitePlus | 12591950 | |
| S58 | Phosphorylation | P53779 (MAPK10) | score2 | phospho.ELM | 12591950 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T38 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S43 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000046476 (hBCL2L11/Phos:2) | pS69 | PRO | |||
| PR:000046477 (hBCL2L11/PhosRes+) | p | PRO | |||
| PR:000025727 (hBCL2L11/iso:1/Phos:1) | pS87 | PRO | 16282323 | ||
| PR:000036641 (hBCL2L11/iso:2/Phos:1) | pS44,pT56,pS58 | PRO | 12591950 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O43521 (BCL2L11) | T116 | P63167 (DYNLL1) | unknown | eFIP | 22742832 | |
| Phosphorylation | P10415 (BCL2) | S70 | O43521 (BCL2L11) | increased_association | eFIP | 24097825 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000025727 (hBCL2L11/iso:1/Phos:1) | Interaction | PR:P31946 (hYWHAB) | PRO | 16282323 | |
| PR:000036641 (hBCL2L11/iso:2/Phos:1) | decreased Interaction | PR:Q96QB1 (hDLC1) | PRO | 12591950 | |
| PR:000044746 (hBCL2L11/iso:2/UnMod) | Interaction | PR:Q96QB1 (hDLC1) | PRO | 12591950 | |
| PR:O43521-2 (hBCL2L11/iso:BimL) | Interaction | PR:Q07812 (hBAX) | PRO | 14764673 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| C12 | R12 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S44 | R44 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| S77 | F77 | Biomuta | DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] | |
| S93 | F93 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S94 | T94 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| Y96 | C96 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S104 | R104 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K112 | T112 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
