iPTMnet Report for O43396 (TXNL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43396 / TXNL1_HUMAN
Protein Name Thioredoxin-like protein 1
Gene Name Name: TXNL1
Synonyms:TRP32,TXL,TXNL;
Organism Homo sapiens (Human)

PRO ID PR:O43396
DAG View
PRO Name thioredoxin-like protein 1 (human)
Definition A thioredoxin-like protein 1 that is encoded in the genome of human.
Short Label hTXNL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43396 (TXNL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S18 Phosphorylation HPRD 20068231
K28 Ubiquitination PhosphoSitePlus
C34 S-Nitrosylation dbSNO 23796488, 23010496
C37 S-Nitrosylation dbSNO 23796488, 23010496
S46 Phosphorylation HPRD   PhosphoSitePlus 20068231
S48 Phosphorylation HPRD   PhosphoSitePlus 20068231
K102 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
S113 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163
T117 Phosphorylation HPRD   PhosphoSitePlus 20166139
K121 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
C149 Methylation IEDB 31844290
K181 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 F46 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S48 I48 Biomuta DOID:4159 / skin cancer [ cosmic ]
T117 K117 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S141 I141 Biomuta DOID:1324 / lung cancer [ cosmic ]
K181 T181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K195 N195 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
K226 T226 Biomuta [ cosmic ]