iPTMnet Report O43318 MAP3K7

Protein Information

UniProt AC / UniProt ID	O43318 / M3K7_HUMAN
Protein Name	Mitogen-activated protein kinase kinase kinase 7
Gene Name	Name: MAP3K7 Synonyms:TAK1;
Organism	Homo sapiens (Human)

PRO ID	PR:O43318 DAG View
PRO Name	mitogen-activated protein kinase kinase kinase 7 (human)
Definition	A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human.
Short Label	hMAP3K7
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O43318 (MAP3K7) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K34 K63 K72 K158 T178 C180 T184 T187 S192 Y206 K209 S268 K269 T333 T344 K346 K351 K354 S361 S367 S371 S375 S383 K386 S389 S393 Y405 S406 T415 S417 S439 T444 T448 S454 S455 S458 S459 T471 S472 K474 T538 K547 K573 K579 Y584 Y585 K590	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
	Phosphorylation		score1	PRO
	Ubiquitination		score1	PRO
K34	Ubiquitination		score1	PRO
K63	Ubiquitination		score1	PhosphoSitePlus
K72	Ubiquitination		score3	PhosphoSitePlus UniProt	22406003
K158	Ubiquitination		score2	PRO PhosphoSitePlus
T178	Acetylation		score1	PhosphoSitePlus
T178	Phosphorylation	O43318 (MAP3K7)	score4	neXtProt PhosphoSitePlus RLIMS-P	25557171, 18617512, 20538596
C180	Methylation		score1	IEDB	31844290
T184	Phosphorylation	O43318 (MAP3K7)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	33052966, 10838074, 18617512, ...30626936, 25557171, 28231796, 30168902, 23472066, 21700900, 19284290, 20538596, 22590573, 28819003
T187	Phosphorylation	O43318 (MAP3K7)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	27486461, 33052966, 30626936, ...17079228, 23472066, 24736749, 26100626, 20538596, 25849436, 24912525, 22590573, 28714004, 28819003, 16845370, 28507161, 19112497, 10838074, 28553204, 28231796, 23229544, 19675569, 19284290, 21512573, 30168902, 15590691, 23646170, 28993672, 19232515, 18299321, 28906490
S192	Phosphorylation	O43318 (MAP3K7)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	10838074, 23472066, 15590691, ...10702308, 20538596
Y206	Phosphorylation		score1	PhosphoSitePlus
K209	Ubiquitination		score1	PhosphoSitePlus
S268	Phosphorylation		score0	RLIMS-P	23472066
K269	Ubiquitination		score1	PhosphoSitePlus
T333	Phosphorylation		score1	PhosphoSitePlus
T344	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	29511289
K346	Ubiquitination		score1	PhosphoSitePlus
K351	Ubiquitination		score1	PhosphoSitePlus
K354	Ubiquitination		score1	PhosphoSitePlus
S361	Phosphorylation		score1	PhosphoSitePlus
S367	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S371	Phosphorylation		score1	PhosphoSitePlus
S375	Phosphorylation		score1	PhosphoSitePlus
S383	O-Glycosylation		score3	GlyGen	23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
K386	Acetylation		score1	PhosphoSitePlus
S389	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19369195, 21406692, 23186163, ...18669648, 29511289, 19690332
S393	Phosphorylation		score1	PhosphoSitePlus
Y405	Phosphorylation		score1	PhosphoSitePlus
S406	Phosphorylation		score1	PhosphoSitePlus
T415	Phosphorylation		score1	PhosphoSitePlus
S417	Phosphorylation		score1	PhosphoSitePlus
S439	O-Glycosylation		score3	GlyGen	23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
S439	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18691976, 21406692, 18088087, ...17081983, 28507161, 19369195, 30626936, 15647289, 18669648, 24275569, 23186163, 19690332, 20068231
T444	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	29511289
T448	O-Glycosylation		score3	GlyGen	23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
T448	Phosphorylation		score1	PhosphoSitePlus
S454	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S455	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S458	Phosphorylation		score1	PhosphoSitePlus
S459	Phosphorylation		score1	PhosphoSitePlus
T471	Phosphorylation		score1	PhosphoSitePlus
S472	Phosphorylation		score1	PhosphoSitePlus
K474	Ubiquitination		score1	PhosphoSitePlus
T538	Phosphorylation		score1	PhosphoSitePlus
K547	Ubiquitination		score1	PhosphoSitePlus
K573	Acetylation		score1	PhosphoSitePlus
K579	Ubiquitination		score1	PhosphoSitePlus
Y584	Phosphorylation		score1	PhosphoSitePlus
Y585	Phosphorylation		score1	PhosphoSitePlus
K590	Ubiquitination		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S69 T184 T187 S192 S389 T403 S406 S439 T446 S454 S455	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1	Source Select all HPRD	PMID
S69	Phosphorylation		score0	HPRD	20068231
T184	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
T187	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S192	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S389	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648, ...20068231
T403	Phosphorylation		score0	HPRD	20068231
S406	Phosphorylation		score0	HPRD	20068231
S439	Phosphorylation		score0	HPRD	19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T446	Phosphorylation		score0	HPRD	20068231
S454	Phosphorylation		score0	HPRD	18669648, 20068231
S455	Phosphorylation		score0	HPRD	19413330, 18669648, 20068231

Search:

Site Select all By amino acid All Serine All Threonine By position S69 T184 T187 S192 S389 S412 T419 S427 S428	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1	Source Select all HPRD	PMID
S69	Phosphorylation		score0	HPRD	20068231
T184	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
T187	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S192	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S389	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648
S412	Phosphorylation		score0	HPRD	19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T419	Phosphorylation		score0	HPRD	20068231
S427	Phosphorylation		score0	HPRD	18669648, 20068231
S428	Phosphorylation		score0	HPRD	19413330, 18669648, 20068231

Search:

Site Select all By amino acid All Serine All Threonine By position S69 T184 T187 S192 S389 T403 S406 S439 T446 S454 S455	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1	Source Select all HPRD	PMID
S69	Phosphorylation		score0	HPRD	20068231
T184	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
T187	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S192	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S389	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648, ...20068231
T403	Phosphorylation		score0	HPRD	20068231
S406	Phosphorylation		score0	HPRD	20068231
S439	Phosphorylation		score0	HPRD	19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T446	Phosphorylation		score0	HPRD	20068231
S454	Phosphorylation		score0	HPRD	18669648, 20068231
S455	Phosphorylation		score0	HPRD	19413330, 18669648, 20068231

Search:

Site Select all By amino acid All Serine All Threonine By position S69 T184 T187 S192 S389 S412 T419 S427 S428	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
S69	Phosphorylation		score0	HPRD	20068231
T184	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
T187	Phosphorylation	O43318 (MAP3K7)	score2	HPRD	10838074, 16845370
S192	Phosphorylation	O43318 (MAP3K7)	score1	HPRD	10838074
S389	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648
S412	Phosphorylation		score0	HPRD	19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T419	Phosphorylation		score0	HPRD	20068231
S427	Phosphorylation		score0	HPRD	18669648, 20068231
S428	Phosphorylation		score0	HPRD	19413330, 18669648, 20068231

Search:

Substrate Select all O14920 (IKBKB) O14920-1 (IKBKB) O43318 (MAP3K7) O43318-1 (MAP3K7) O43318-4 (MAP3K7) P26045 (PTPN3) P52564 (MAP2K6) P54646 (PRKAA2) P56524 (HDAC4) P84022-1 (SMAD3) Q01094 (E2F1) Q15750 (TAB1) Q8IVT5 (KSR1) Q8WUI4 (HDAC7) Q9UQL6 (HDAC5)	Site Select all By amino acid All Serine All Threonine By position S155 T172 S177 T178 S181 T184 T187 S192 S207 T211 S246 S259 S337 S359 S406 S422 S423 S425 S452 S453 S456 S457	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus Signor UniProt neXtProt phospho.ELM	PMID
O14920 (IKBKB)	S177	score3	HPRD Signor	11460167, 10195894, 10022904, ...9689078, 10779355
O14920-1 (IKBKB)	S181	score3	HPRD Signor	11460167, 10195894, 10022904, ...9689078, 10779355
O43318 (MAP3K7)	T178	score4	neXtProt PhosphoSitePlus	18617512, 20538596
O43318 (MAP3K7)	T184	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	10838074, 18617512, 20538596
O43318-1 (MAP3K7)	T187	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	10838074, 15590691, 20538596, ...16845370
O43318-4 (MAP3K7)	S192	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	10838074, 20538596, 10702308
P26045 (PTPN3)	S359	score3	PhosphoSitePlus Signor	9341175
P52564 (MAP2K6)	S207	score2	PhosphoSitePlus	11460167
P52564 (MAP2K6)	T211	score2	PhosphoSitePlus	11460167
P54646 (PRKAA2)	T172	score2	PhosphoSitePlus	20538596
P56524 (HDAC4)	S246	score2	PhosphoSitePlus	16980613
P84022-1 (SMAD3)	S422	score1	HPRD	9380693
P84022-1 (SMAD3)	S423	score1	HPRD	9380693
P84022-1 (SMAD3)	S425	score1	HPRD	9380693
Q01094 (E2F1)	S337	score2	PhosphoSitePlus	26724859
Q15750 (TAB1)	S452	score2	PhosphoSitePlus	22216226
Q15750 (TAB1)	S453	score2	PhosphoSitePlus	22216226
Q15750 (TAB1)	S456	score2	PhosphoSitePlus	22216226
Q15750 (TAB1)	S457	score2	PhosphoSitePlus	22216226
Q8IVT5 (KSR1)	S406	score4	PhosphoSitePlus Signor	11741534, 12941695
Q8WUI4 (HDAC7)	S155	score3	PhosphoSitePlus Signor	16980613
Q9UQL6 (HDAC5)	S259	score2	PhosphoSitePlus	16980613

Search:

PRO ID (Short Label) Select all PR:000035831 (hIKBKB/Phos:1)	Sites Select all pS177,pS181	PTM Enzyme	Source Select all PRO	PMID
PR:000035831 (hIKBKB/Phos:1)	pS177,pS181	PR:000035736 (hMAP3K7/Phos:1)	PRO

Proteoforms

Search:

PRO ID (Short Label) Select all PR:000035736 (hMAP3K7/Phos:1) PR:000048307 (hMAP3K7/Phos:2) PR:000048308 (hMAP3K7/PhosRes+) PR:000048309 (hMAP3K7/Ubiq:1) PR:000048310 (hMAP3K7/UbiqLys+)	Sites Select all p pT184,pT187 pT187 ub ubK34,ubK158	Source Select all PRO
PR:000035736 (hMAP3K7/Phos:1)	pT184,pT187	PRO
PR:000048307 (hMAP3K7/Phos:2)	pT187	PRO
PR:000048308 (hMAP3K7/PhosRes+)	p	PRO
PR:000048309 (hMAP3K7/Ubiq:1)	ubK34,ubK158	PRO
PR:000048310 (hMAP3K7/UbiqLys+)	ub	PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S69 T184 T187 Y206 K209 S268 K269 K346 S361 S367 S389 S393 S406 S417 S458 S472 T538 K573 Y585	Variant Select all A184 C206 C585 E209 E269 F406 I187 I361 I367 K538 L417 M346 N389 N573 P393 P472 T458 T573 Y268 Y69	Source Select all Biomuta	Disease [Sample source] Select all DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:363 / uterine cancer [ icgc, icgc, icgc ] DOID:1319 / brain cancer [ icgc, icgc, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S69	Y69	Biomuta	DOID:363 / uterine cancer [ icgc, icgc, icgc ] DOID:1319 / brain cancer [ icgc, icgc, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ]
T184	A184	Biomuta	DOID:1319 / brain cancer [ icgc ]
T187	I187	Biomuta	DOID:363 / uterine cancer [ icgc ]
Y206	C206	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K209	E209	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S268	Y268	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
K269	E269	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K346	M346	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S361	I361	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S367	I367	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S389	N389	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S393	P393	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S406	F406	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S417	L417	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S458	T458	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S472	P472	Biomuta	DOID:363 / uterine cancer [ icgc ]
T538	K538	Biomuta	DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K573	N573	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K573	T573	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y585	C585	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O43318 (MAP3K7)

Protein Information

Interactive Sequence View

O43318 (MAP3K7) as Substrate

O43318 (MAP3K7) as PTM Enzyme

Proteoforms

PTM sites affected in variants