iPTMnet Report for O43318 (MAP3K7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43318 / M3K7_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 7
Gene Name Name: MAP3K7
Synonyms:TAK1;
Organism Homo sapiens (Human)

PRO ID PR:O43318
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 7 (human)
Definition A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human.
Short Label hMAP3K7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43318 (MAP3K7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
K34 Ubiquitination PRO
K63 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus   UniProt 22406003
K158 Ubiquitination PRO   PhosphoSitePlus
T178 Acetylation PhosphoSitePlus
T178 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 25557171, 18617512, 20538596
T178 Phosphorylation O43318 (MAP3K7) neXtProt   PhosphoSitePlus 18617512, 20538596
C180 Methylation IEDB 31844290
T184 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 33052966, 10838074, 18617512, ...30626936, 25557171, 28231796, 30168902, 23472066, 21700900, 19284290, 20538596, 22590573, 28819003
T184 Phosphorylation O43318 (MAP3K7) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10838074, 18617512, 20538596
T187 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 27486461, 33052966, 30626936, ...17079228, 23472066, 24736749, 26100626, 20538596, 25849436, 24912525, 22590573, 28714004, 28819003, 16845370, 28507161, 19112497, 10838074, 28553204, 28231796, 23229544, 19675569, 19284290, 21512573, 30168902, 15590691, 23646170, 28993672, 19232515, 18299321, 28906490
T187 Phosphorylation O43318 (MAP3K7) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10838074, 15590691, 20538596, ...16845370
S192 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10838074, 23472066, 15590691, ...10702308, 20538596
S192 Phosphorylation O43318 (MAP3K7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10838074, 20538596, 10702308
Y206 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S268 Phosphorylation RLIMS-P 23472066
K269 Ubiquitination PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus   RLIMS-P 29511289
K346 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus   UniProt 23186163
S371 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S383 O-Glycosylation GlyGen 23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
K386 Acetylation PhosphoSitePlus
S389 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 21406692, 23186163, ...18669648, 29511289, 19690332
S393 Phosphorylation PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S439 O-Glycosylation GlyGen 23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
S439 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 18088087, ...17081983, 28507161, 19369195, 30626936, 15647289, 18669648, 24275569, 23186163, 19690332, 20068231
T444 Phosphorylation PhosphoSitePlus   RLIMS-P 29511289
T448 O-Glycosylation GlyGen 23301498, 36032089, 31492838, ...35254053, 34019948, 30620550, 28657654, 30059200
T448 Phosphorylation PhosphoSitePlus
S454 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S455 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S458 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K573 Acetylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
Y585 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 20068231
T184 Phosphorylation HPRD 10838074
T184 Phosphorylation O43318 (MAP3K7) HPRD 10838074
T187 Phosphorylation HPRD 10838074
T187 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S192 Phosphorylation HPRD 10838074
S192 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S389 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T403 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 20068231
S439 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T446 Phosphorylation HPRD 20068231
S454 Phosphorylation HPRD 18669648, 20068231
S455 Phosphorylation HPRD 19413330, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 20068231
T184 Phosphorylation HPRD 10838074
T184 Phosphorylation O43318 (MAP3K7) HPRD 10838074
T187 Phosphorylation HPRD 10838074
T187 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S192 Phosphorylation HPRD 10838074
S192 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S389 Phosphorylation HPRD 17322306, 19651622, 18669648
S412 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T419 Phosphorylation HPRD 20068231
S427 Phosphorylation HPRD 18669648, 20068231
S428 Phosphorylation HPRD 19413330, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 20068231
T184 Phosphorylation HPRD 10838074
T184 Phosphorylation O43318 (MAP3K7) HPRD 10838074
T187 Phosphorylation HPRD 10838074
T187 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S192 Phosphorylation HPRD 10838074
S192 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S389 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T403 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 20068231
S439 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T446 Phosphorylation HPRD 20068231
S454 Phosphorylation HPRD 18669648, 20068231
S455 Phosphorylation HPRD 19413330, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 20068231
T184 Phosphorylation HPRD 10838074
T184 Phosphorylation O43318 (MAP3K7) HPRD 10838074
T187 Phosphorylation HPRD 10838074, 16845370
T187 Phosphorylation O43318 (MAP3K7) HPRD 10838074, 16845370
S192 Phosphorylation HPRD 10838074
S192 Phosphorylation O43318 (MAP3K7) HPRD 10838074
S389 Phosphorylation HPRD 17322306, 19651622, 18669648
S412 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 18212344
T419 Phosphorylation HPRD 20068231
S427 Phosphorylation HPRD 18669648, 20068231
S428 Phosphorylation HPRD 19413330, 18669648, 20068231


O43318 (MAP3K7) as PTM Enzyme



Substrate Site Score Source PMID
O14920 (IKBKB) S177 HPRD   Signor 11460167, 10195894, 10022904, ...9689078, 10779355
O14920-1 (IKBKB) S181 HPRD   Signor 11460167, 10195894, 10022904, ...9689078, 10779355
O43318 (MAP3K7) T178 neXtProt   PhosphoSitePlus 18617512, 20538596
O43318 (MAP3K7) T184 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10838074, 18617512, 20538596
O43318-1 (MAP3K7) T187 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10838074, 15590691, 20538596, ...16845370
O43318-4 (MAP3K7) S192 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10838074, 20538596, 10702308
P26045 (PTPN3) S359 PhosphoSitePlus   Signor 9341175
P52564 (MAP2K6) S207 PhosphoSitePlus 11460167
P52564 (MAP2K6) T211 PhosphoSitePlus 11460167
P54646 (PRKAA2) T172 PhosphoSitePlus 20538596
P56524 (HDAC4) S246 PhosphoSitePlus 16980613
P84022-1 (SMAD3) S422 HPRD 9380693
P84022-1 (SMAD3) S423 HPRD 9380693
P84022-1 (SMAD3) S425 HPRD 9380693
Q01094 (E2F1) S337 PhosphoSitePlus 26724859
Q15750 (TAB1) S452 PhosphoSitePlus 22216226
Q15750 (TAB1) S453 PhosphoSitePlus 22216226
Q15750 (TAB1) S456 PhosphoSitePlus 22216226
Q15750 (TAB1) S457 PhosphoSitePlus 22216226
Q8IVT5 (KSR1) S406 PhosphoSitePlus   Signor 11741534, 12941695
Q8WUI4 (HDAC7) S155 PhosphoSitePlus   Signor 16980613
Q9UQL6 (HDAC5) S259 PhosphoSitePlus 16980613
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035831 (hIKBKB/Phos:1) pS177,pS181 PR:000035736 (hMAP3K7/Phos:1) PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035736 (hMAP3K7/Phos:1) pT184,pT187 PRO
PR:000048307 (hMAP3K7/Phos:2) pT187 PRO
PR:000048308 (hMAP3K7/PhosRes+) p PRO
PR:000048309 (hMAP3K7/Ubiq:1) ubK34,ubK158 PRO
PR:000048310 (hMAP3K7/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 Y69 Biomuta DOID:363 / uterine cancer [ icgc, icgc, icgc ] DOID:1319 / brain cancer [ icgc, icgc, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ]
T184 A184 Biomuta DOID:1319 / brain cancer [ icgc ]
T187 I187 Biomuta DOID:363 / uterine cancer [ icgc ]
Y206 C206 Biomuta DOID:3571 / liver cancer [ cosmic ]
K209 E209 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S268 Y268 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K269 E269 Biomuta DOID:3571 / liver cancer [ cosmic ]
K346 M346 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S361 I361 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S367 I367 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S389 N389 Biomuta DOID:4159 / skin cancer [ cosmic ]
S393 P393 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S406 F406 Biomuta DOID:1612 / breast cancer [ cosmic ]
S417 L417 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S458 T458 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S472 P472 Biomuta DOID:363 / uterine cancer [ icgc ]
T538 K538 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K573 N573 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K573 T573 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y585 C585 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]