iPTMnet Report for O43156 (TTI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43156 / TTI1_HUMAN
Protein Name TELO2-interacting protein 1 homolog
Gene Name Name: TTI1
Synonyms:KIAA0406,SMG10;
Organism Homo sapiens (Human)

PRO ID PR:O43156
DAG View
PRO Name TELO2-interacting protein 1 homolog (human)
Definition A TELO2-interacting protein 1 homolog that is encoded in the genome of human.
Short Label hTTI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43156 (TTI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S167 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
C297 Methylation IEDB 31844290
K353 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
S459 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19664994, 19691289, 20068231
K461 Ubiquitination PhosphoSitePlus
C492 Methylation IEDB 31844290
K547 Ubiquitination PhosphoSitePlus
C646 Methylation IEDB 31844290
Y816 Phosphorylation IEDB 35494241
K818 Ubiquitination PhosphoSitePlus
S828 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 23263282, 23186163
K877 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
S959 Phosphorylation HPRD 20068231
T962 Phosphorylation HPRD   PhosphoSitePlus 20068231
S967 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1077 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K253 N253 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K261 N261 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S828 L828 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K877 Q877 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S959 F959 Biomuta DOID:4159 / skin cancer [ cosmic ]